A multitasker for tone and texture
Azelaic acid is the quiet workhorse of dermatology. It helps even tone, calm visible redness, and clear bumps. Compounded here with tretinoin and niacinamide by a US-licensed pharmacy.
- 30g tubeSupply
- 3 activesIn one formula
- Provider reviewedBefore anything ships
The people pictured are models, not patients.
RxPrescription Skincare
Azelaic Acid Cream
The multitasker for tone and texture.
40,000+ products sold · LegitScript certified
Azelaic acid cream · With tretinoin and niacinamide
- Evens tone and calms redness
- Azelaic acid, tretinoin, and niacinamide
- Gentle enough for reactive skin
- Provider-reviewed
What's Included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
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1-Month Plan
$134- $134 Billed Today
- Then $134 Every Month
- Cancel Anytime
Or pay with
$134 billed today, then every month until canceled.
Not prescribed? Full refund.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before anything ships.
Full refund if not prescribed Free, discreet shipping Cancel anytime
Order today and here is what happens next
- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships in 3 to 5 daysEstimated ship date, if prescribed
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
What does azelaic acid do?
Azelaic acid evens skin tone, calms redness and helps clear bumps by acting on inflammation, bacteria and pigment production, and it is gentle enough for reactive skin.
Is azelaic acid good for hyperpigmentation?
Yes. It inhibits the enzyme behind melanin production, which is why it is used for post-inflammatory marks and uneven tone, especially in skin that reacts to hydroquinone.
Can azelaic acid treat rosacea and acne?
It is used for both, because its anti-inflammatory and antibacterial activity addresses the bumps and redness common to each.
LegitScript certifiedCert. 50087439- US-licensed pharmacyPrepares every prescription
- Independent cliniciansUS-licensed, in your state
- 40,000+Products sold
- All 50 statesFree, discreet shipping
- No insurance requiredOne price, shown up front
Evening skincare
The multitasker for tone and texture.
- 01Evens tone and calms redness
- 02Azelaic acid, tretinoin, and niacinamide
- 03Gentle enough for reactive skin
- 04Provider-reviewed
The people pictured are models, not patients.
Why Azelaic Acid Cream
Three actives in one cream
Azelaic acid 5 percent for tone, tretinoin 0.03 percent for texture, and niacinamide 4 percent for the barrier. One nightly step.
Gentle enough for reactive skin
Azelaic acid tends to be well tolerated by skin that reacts to stronger actives, though the added tretinoin can still cause some early dryness.
A provider reviews your skin
A US-licensed provider confirms this formula is appropriate for you before it ships. Real pricing, shown up front.
How we compare
Azelaic Acid Cream, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Understand your treatment
A different path to clearer-looking skin.
This cream combines azelaic acid 5%, tretinoin 0.03% and niacinamide 4%. Azelaic acid has research in acne, rosacea and pigmentation care. Tretinoin brings retinoid signaling, while niacinamide adds a vitamin B3 ingredient. The complete formula matters as much as the azelaic-acid name: this is a blended cream, rather than a single-ingredient azelaic product. Think about redness, blemishes, tone and texture as separate goals when comparing nearby skincare options.
A closer look
A different path to clearer-looking skin.
Azelaic acid 5%
Tretinoin 0.03%
Niacinamide 4%
Make a more informed choice
Azelaic acid vs. a retinoid
Azelaic acid and tretinoin have different mechanisms and research histories. Look at the complete formula on each listing, rather than assuming two skin creams solve the same concern in the same way.
Explore the ingredient research
- Elewski BE, Fleischer AB Jr, Pariser DM. A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. Arch Dermatol. 2003;139(11):1444-1450.
- Weiss JS, et al. Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study. JAMA. 1988;259(4):527-532.
- Hakozaki T, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002;147(1):20-31.
HealthRX.com verified facts
Azelaic Acid Cream online: price and access
Azelaic Acid Cream starts at $107 per month on 12-month plan; the lowest checkout charge is $134 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified August 26, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A licensed physician (MD) reviews your completed intake and prescribes your azelaic acid cream if it is appropriate for you.
Ships to your door
A US-licensed pharmacy compounds your cream and ships it free in discreet packaging.
Ongoing support
Message your care team anytime, and your provider adjusts your plan as your skin responds.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
About Azelaic Acid Cream
Azelaic acid is the quiet workhorse of dermatology: it evens tone, calms redness and helps clear bumps, and it is gentle enough for skin that reacts to other actives. Here it is paired with a low dose of tretinoin and niacinamide. Your provider reviews your skin first. Compounded by a US-licensed pharmacy.
- Evens tone and helps with redness
- Gentle enough for reactive skin
- Paired with tretinoin and niacinamide
- Real pricing up front, discreet shipping
Azelaic acid has anti-inflammatory, antibacterial and tyrosinase-inhibiting activity; tretinoin adds turnover and niacinamide calms redness. Compounded by a US-licensed pharmacy.
Azelaic acid evens tone
It calms the inflammation behind redness and helps fade the dark marks left by breakouts.
Tretinoin refines texture
The retinoid speeds cell turnover to smooth roughness and help keep pores clear.
Niacinamide steadies the barrier
Niacinamide 4 percent supports the barrier and helps keep redness down while the other actives work.
Azelaic acid, tretinoin, and niacinamide together target uneven tone, rough texture, and visible redness.
What the research shows
This exact three-in-one formula has not been studied as a single product. Each active has its own research, so here is what the studies show for azelaic acid, tretinoin, and niacinamide on their own.
251 patients
Azelaic acid has been studied on its own for rosacea. In a randomized, double-blind trial of 251 patients, azelaic acid gel reduced inflammatory lesions more than the comparator.
Elewski et al., Arch Dermatol 2003
14 of 15
Tretinoin has been studied on its own for photoaging. In a randomized, vehicle-controlled trial, 14 of 15 people treating their face with tretinoin improved, versus none on vehicle.
Weiss et al., JAMA 1988
35 to 68%
Niacinamide has been studied on its own for tone. In lab and clinical work it inhibited melanosome transfer by 35 to 68 percent and reduced hyperpigmentation versus vehicle.
Hakozaki et al., Br J Dermatol 2002
References
- Elewski BE, Fleischer AB Jr, Pariser DM. A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. Arch Dermatol. 2003;139(11):1444-1450.
- Weiss JS, et al. Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study. JAMA. 1988;259(4):527-532.
- Hakozaki T, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002;147(1):20-31.
Azelaic acid formula or Tretinoin alone
Two ways to treat tone and texture
| Azelaic acid formula | Tretinoin alone | |
|---|---|---|
| Evens tone | Azelaic acid and niacinamide target tone | Limited effect on redness |
| Calms redness | Azelaic acid helps calm visible redness | Can increase redness early |
| Texture | Includes tretinoin 0.03% for texture | Higher tretinoin strengths available |
| Tolerability | Gentle enough for reactive skin | Often more irritating |
| Routine | Three actives in one cream | Retinoid only |
| Best for | Uneven tone, redness, and breakouts together | Lines and texture at higher strength |
What to expect
Tone and texture usually shift over six to twelve weeks. It is well tolerated, though mild tingling early on is normal.
Weeks 1 to 2
Start your cream
Apply a pea-sized amount at night after your provider confirms your prescription. Mild tingling is common at first.
Weeks 3 to 5
Skin settles
Any early dryness from the tretinoin usually eases. Keep applying nightly and message your care team with questions.
Weeks 6 to 8
Tone starts to even
Redness and dark marks often begin to look more even in this window.
Weeks 8 to 12
Texture and clarity build
Tone and texture usually shift over six to twelve weeks, then build with continued use.
Safety and side effects
Reviewed by a licensed provider. Mild tingling or dryness can occur early. The retinoid component raises sun sensitivity.
Common
- Tingling or itching on application
- Mild burning or stinging
- Dryness and light peeling from the tretinoin
- Temporary redness
Less common
- A temporary purge of breakouts as skin adjusts
- Increased sun sensitivity
- Temporary lightening of the skin, most noticeable on deeper skin tones
Seek care
- Severe swelling, blistering, or crusting of the skin
- Signs of an allergic reaction such as rash or swelling of the lips or throat
This formula contains tretinoin, a retinoid, and must be avoided if you are pregnant, planning to become pregnant, or breastfeeding. Expect a short adjustment period of tingling and light peeling, and a possible purge in the first several weeks. The tretinoin increases sun sensitivity, so apply at night and use sunscreen daily. Azelaic acid can occasionally lighten the skin, which is most noticeable on deeper skin tones. This is not a complete list of side effects. Tell your provider about every medication and skincare product you use before starting.
Frequently asked questions
How long does azelaic acid take to work?
Tone and texture usually shift over six to twelve weeks of consistent use.
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Learn MoreAdd to your daily routine.
No prescription needed. Dietary supplements to keep alongside your skin care routine, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Choose a planNo insurance required
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.