Dapsone targets inflamed breakouts
Topical dapsone calms the inflammation behind red, tender papules and pustules, the kind of acne that surface washes tend to miss.
- 30g tubeSupply
- 3 activesIn one formula
- Provider reviewedBefore anything ships
The people pictured are models, not patients.
RxPrescription Skincare
Dapsone Acne Cream
Prescription acne care, compounded.
40,000+ products sold · LegitScript certified
Dapsone acne cream · With tretinoin and niacinamide
- Dapsone for inflammatory acne
- Retinoid plus niacinamide
- Three actives, one cream
- Provider-reviewed
What's Included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
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Choose Your Plan
1-Month Plan
$179- $179 Billed Today
- Then $179 Every Month
- Cancel Anytime
Or pay with
$179 billed today, then every month until canceled.
Not prescribed? Full refund.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your dapsone cream ships.
Full refund if not prescribed Free, discreet shipping Cancel anytime
Order today and here is what happens next
- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships in 3 to 5 daysEstimated ship date, if prescribed
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
What is dapsone used for on skin?
Topical dapsone is used for inflammatory acne. It has anti-inflammatory and antimicrobial activity, and here it is paired with tretinoin and niacinamide.
How does dapsone treat acne?
Dapsone reduces the inflammation that drives red, tender acne, while the added tretinoin clears pores and niacinamide calms redness.
Is this better than benzoyl peroxide?
It is a different, prescription approach. A provider may choose it for inflammatory acne that over-the-counter benzoyl peroxide has not controlled.
LegitScript certifiedCert. 50087439- US-licensed pharmacyPrepares every prescription
- Independent cliniciansUS-licensed, in your state
- 40,000+Products sold
- All 50 statesFree, discreet shipping
- No insurance requiredOne price, shown up front
Evening routine
Prescription acne care, compounded.
- 01Dapsone for inflammatory acne
- 02Retinoid plus niacinamide
- 03Three actives, one cream
- 04Provider-reviewed
The people pictured are models, not patients.
Why Dapsone Acne Cream
A retinoid to keep pores clear
Tretinoin speeds skin cell turnover so pores stay unclogged, which is what keeps new comedones and breakouts from forming.
Niacinamide to steady your skin
Niacinamide 4% helps calm redness and support your skin barrier while the other actives do their work.
A provider reviews your skin
A US-licensed provider confirms this cream is appropriate for your acne before it ships. Real pricing, shown up front.
How we compare
Dapsone Acne Cream, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Understand your treatment
An acne option with a distinct active ingredient.
This cream combines dapsone 3%, tretinoin 0.07% and niacinamide 4%. Dapsone has anti-inflammatory activity and topical acne research. Tretinoin brings a retinoid component, while niacinamide adds a vitamin B3 ingredient. That makes this a blended acne formulation rather than a single-ingredient dapsone product. The relevant comparison is the pattern of blemishes, the complete formula and the active ingredients already in your routine.
A closer look
An acne option with a distinct active ingredient.
Dapsone 3%
Tretinoin 0.07%
Niacinamide 4%
Make a more informed choice
Dapsone vs. an exfoliating acid
Salicylic acid is a beta hydroxy acid. Dapsone is a different active ingredient with its own acne research. Compare the ingredient class and the complete formulation.
Explore the ingredient research
- Draelos ZD, et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. 2007;56(3):439.e1-439.e10.
- Shalita AR, et al. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995;34(6):434-437.
HealthRX.com verified facts
Dapsone Acne Cream online: price and access
Dapsone Acne Cream starts at $143 per month on 12-month plan; the lowest checkout charge is $179 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified August 26, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A licensed physician (MD) reviews your completed intake and prescribes your cream if it is appropriate for you.
Ships to your door
A US-licensed pharmacy compounds your formula and ships it free in discreet packaging.
Ongoing support
Message your care team anytime, and your provider adjusts your plan as your skin responds.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
About Dapsone Acne Cream
Dapsone targets the inflammation behind red, angry acne, and it is paired here with tretinoin to clear pores and niacinamide to calm redness. It is a prescription approach for acne that has not responded to over-the-counter routines. Your provider reviews your skin first. Compounded by a US-licensed pharmacy.
- Dapsone for inflammatory acne
- Paired with tretinoin and niacinamide
- A step up from over-the-counter routines
- Real pricing up front, discreet shipping
Dapsone has anti-inflammatory and antimicrobial activity; tretinoin normalizes follicular turnover; niacinamide calms redness. Compounded by a US-licensed pharmacy.
Dapsone calms inflammation
It reduces the inflammatory activity that turns a clogged pore into a red, swollen breakout.
Tretinoin clears the pore
The retinoid speeds cell turnover so dead skin and oil stop plugging the follicle.
Niacinamide supports the barrier
It helps reduce redness and keeps your skin barrier steadier while you treat.
Inflammation settles and clogged pores clear, so fewer new breakouts can form.
What the research shows
The actives in your cream have each been studied on their own for acne. This exact compounded combination has not been tested as a single product, so the research below reflects the individual ingredients, studied at their own strengths.
3,010
Across two 12-week randomized, vehicle-controlled trials in 3,010 people, topical dapsone significantly reduced inflammatory acne lesions compared with vehicle.
Draelos et al., J Am Acad Dermatol 2007
82%
In a randomized comparison in inflammatory acne, topical niacinamide 4% improved 82 percent of patients over 8 weeks, comparable to topical clindamycin.
Shalita et al., Int J Dermatol 1995
References
- Draelos ZD, et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. 2007;56(3):439.e1-439.e10.
- Shalita AR, et al. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995;34(6):434-437.
Compounded dapsone cream or Over-the-counter acne products
Two ways to approach inflammatory acne
| Compounded dapsone cream | Over-the-counter acne products | |
|---|---|---|
| Prescription dapsone | Yes | Not sold over the counter |
| Targets inflammation directly | Yes, through dapsone | Mostly benzoyl peroxide or salicylic acid |
| Prescription retinoid included | Yes, tretinoin | Over-the-counter adapalene at most |
| Products to manage | One compounded cream | Often several layered products |
| Provider oversight | Reviewed by a provider | None |
| Cost up front | Higher, provider and prescription included | Lower |
What to expect
Inflammation and new breakouts often ease over four to eight weeks. Some early dryness from the retinoid is normal. Daily sunscreen applies.
Weeks 1 to 2
Start your cream
Begin applying after your provider confirms your prescription. Some dryness, flaking, or a short purge from the retinoid is normal as your skin adjusts.
Weeks 4 to 8
Inflammation eases
Red, inflamed breakouts and new spots often begin to settle in this window. Keep applying as directed and use sunscreen by day.
Months 2 to 3
Skin evens out
As turnover continues, tone and texture tend to look more even and breakouts become less frequent.
Ongoing
Maintain your results
Your provider adjusts strength and frequency to hold your results with the lowest effective routine.
Safety and side effects
Reviewed by a licensed provider. Tell your provider about G6PD deficiency. Raises sun sensitivity from the retinoid; not used in pregnancy.
Common
- Dryness or peeling from the retinoid
- Redness or irritation at the application site
- Temporary stinging on application
- Increased sensitivity to the sun
Less common
- Skin tight or flaky enough to need a lighter schedule
- Temporary worsening or purge early in treatment
- Contact dermatitis
Seek care
- Signs of red blood cell breakdown such as unusual tiredness, pale skin, or shortness of breath, mainly a concern with G6PD deficiency
- Severe allergic reaction
This is not a complete list of side effects. Tell your provider if you have G6PD deficiency, since dapsone can rarely affect red blood cells, a concern mainly at higher exposures. The retinoid in this cream raises sun sensitivity, so wear sunscreen daily, and this cream is not used in pregnancy. Tell your provider about every medication and product you use before starting.
Frequently asked questions
How long until dapsone clears acne?
Many people see inflammation and breakouts ease over four to eight weeks, with continued improvement on consistent use.
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Learn MoreAdd to your daily routine.
No prescription needed. Dietary supplements to keep alongside your skin care routine, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Choose a planNo insurance required
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.