Estriol 0.3%
A topical estrogen ingredient, distinct from the oral and patch hormone options.
- 30 gram containerSupply
- 3 activesIn one formula
- Provider reviewedBefore anything ships
Illustrative photography with models, not patients.
RxPrescription Skincare
Estriol / Vitamin C / Hyaluronic Acid
Three ingredients, one skin-focused formula.
40,000+ products sold · LegitScript certified
Estriol 0.3%, vitamin C 5% and hydrolyzed hyaluronic acid 0.5%. Explore the estrogen, antioxidant and moisture-binding components of this topical blend.
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- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships to your doorIf prescribed, in a plain box
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
Is this the same as oral estradiol?
No. This is a topical skincare formula containing estriol, vitamin C and hydrolyzed hyaluronic acid. Oral estradiol is a different product.
What ingredients and strengths are included?
Estriol 0.3%, vitamin C 5% and hydrolyzed hyaluronic acid 0.5%.
Can I subscribe or make a one-time purchase?
Yes. Choose Subscribe & Save or One-time purchase in the plan picker. The price and selected plan are displayed before checkout.
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- 40,000+Products sold
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- No insurance requiredOne price, shown up front
Evening skincare
Three ingredients, one skin-focused formula.
- 01Estriol 0.3%
- 02Vitamin C 5%
- 03Hydrolyzed hyaluronic acid 0.5%
Illustrative photography with models, not patients.
Why Estriol / Vitamin C / Hyaluronic Acid
Vitamin C 5%
A skin-focused ingredient studied in topical photoaging formulations.
Hydrolyzed hyaluronic acid 0.5%
A moisture-focused ingredient included alongside estriol and vitamin C.
Three ingredients together
One blended topical formula instead of three separate products.
How we compare
Estriol / Vitamin C / Hyaluronic Acid, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Meet the formula
Skin changes deserve a more specific formula story.
Dryness, a change in skin texture and the appearance of fine lines can arrive together, but they describe different aspects of skin. This topical blend combines three ingredients from three families: estriol, an estrogen; vitamin C, an antioxidant ingredient; and hydrolyzed hyaluronic acid, a humectant. Reading those roles separately makes the formula easier to understand than calling it simply a hydrating cream. Its identity is the combination and the listed strengths, brought together in one topical product.
01
Estriol
Estrogen ingredient with topical skin research
02
Vitamin C
Antioxidant ingredient and collagen-biology research
03
Hyaluronic acid
Humectant that attracts and holds water
Inside the formula
The names on the label, explained.
0.3%
Estriol
Estriol is an estrogen, a hormone-family ingredient that distinguishes this formula from a conventional moisturizing serum. Researchers have studied topical estrogens in aging skin, examining measures such as moisture, elasticity and wrinkle appearance. Estriol supplies that ingredient family within the blend; it is separate from the humectant role of hyaluronic acid and the antioxidant role of vitamin C.
5%
Vitamin C
Vitamin C is an antioxidant and is involved in collagen biosynthesis. Topical vitamin C has also been studied in photoaged skin. Its presence gives this formula a different ingredient profile from an estriol-only product. The concentration describes the listed vitamin C component; the complete product remains a three-ingredient topical blend.
0.5%
Hydrolyzed hyaluronic acid
Hyaluronic acid is a humectant, an ingredient that attracts and holds water. Hydrolyzed describes a processed form of the molecule. This is the moisture-focused ingredient in the listing. That role helps explain why the feel of hydration is a separate part of the formula story from estrogen signaling or the biology studied with topical vitamin C.
A closer look / 01
Moisture, texture and tone ask different questions.
Moisture concerns how hydrated skin feels and behaves. Texture concerns the feel and visible surface of the skin. Tone concerns color and pigmentation. Keeping those three goals separate is useful when comparing this blend with a simple hyaluronic-acid serum, a retinoid cream or a pigment-focused formula. The products may share a skincare shelf while offering different active ingredients.
This blend’s distinguishing feature is the estriol component alongside vitamin C and hyaluronic acid. A hydrating serum may share a humectant but lacks that same full ingredient map. A tretinoin blend introduces a retinoid, which belongs to another pharmacologic family. Compare the complete active list to understand what changes from one option to the next.
A closer look / 02
Three percentages, three formula specifications.
The listing contains estriol 0.3%, vitamin C 5% and hydrolyzed hyaluronic acid 0.5%. Each figure belongs to its own ingredient. Adding them together would hide the information that makes the blend distinctive. Similarly, a vitamin C serum with a different percentage is a separate formulation, rather than a direct measure of the strength of this complete product.
A closer look / 03
A closer look at the ingredient research.
The linked topical-estrogen study examined aging-skin measures using estrogen formulations. The linked vitamin C trial evaluated a vitamin C cream against its vehicle on photoaged skin. Those are useful examples of how researchers separate ingredient effects from a cream’s base and choose specific skin measurements. They offer context for the ingredient families, while this listing identifies a combined estriol, vitamin C and hyaluronic-acid product.
Make an informed comparison
Compare the actual ingredients and formats.
The comparison starts with what you want to understand about your skin. Moisture binding, estrogen ingredients and retinoid signaling are distinct roles. This formula brings an estrogen ingredient and vitamin C together with a humectant in one topical blend.
| Option | Ingredient identity | What distinguishes it |
|---|---|---|
| This blend | Estriol / vitamin C / hydrolyzed hyaluronic acid | Estrogen, antioxidant and hydration components |
| Hyaluronic-acid serum | Hyaluronic acid | Primarily moisture binding |
| Tretinoin / Niacinamide / Vitamin C | Tretinoin / niacinamide / vitamin C | Retinoid-centered topical blend |
The useful details
A few questions worth answering.
Is estriol another name for tretinoin?
Estriol is an estrogen; tretinoin is a retinoid. They belong to different ingredient families and have different research histories. Vitamin C can appear alongside either in a formula, which makes checking the full active list more informative than recognizing one shared ingredient.
What would I track in a skincare record?
Separate dryness, texture and the appearance of fine lines. Note how the cream feels in your existing routine and use comparable lighting for photos. That produces a more useful record than one overall skin score, because moisture and visible surface changes describe different observations.
Explore the ingredient research
Follow the sources.
See the available product options.
View optionsA straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A licensed provider reviews your health history and determines whether this treatment is appropriate for you.
Ships to your door
If prescribed, a US-licensed pharmacy prepares and ships your medication.
Ongoing support
Contact the care team with questions about your treatment or order.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
Formula details, research & comparisons
About Estriol / Vitamin C / Hyaluronic Acid
This topical formula pairs estriol with vitamin C and hydrolyzed hyaluronic acid. Estriol is an estrogen ingredient studied in aging skin; vitamin C has its own topical skin research, while hyaluronic acid brings a moisture-focused component. The three ingredients come together in one formulation.
- Estriol 0.3%
- Vitamin C 5%
- Hydrolyzed hyaluronic acid 0.5%
Estriol
The estrogen component has been studied in topical aging-skin care.
Vitamin C
The formula includes vitamin C alongside the estriol component.
Hyaluronic acid
The third ingredient adds a moisture-focused component.
What the research shows
The references below study topical estrogen and vitamin C formulations separately. The estrogen study compared estriol 0.3% with estradiol 0.01%; the vitamin C study evaluated a separate cream.
59 participants
The topical-estrogen study compared two estrogen formulations over six months.
Schmidt et al., 1996
6 months
A separate randomized vitamin C cream study assessed photoaged skin over six months.
Humbert et al., 2003
Estriol + Vitamin C + Hyaluronic Acid or Tretinoin + Niacinamide
Compare the ingredients and format before choosing your plan.
| Estriol + Vitamin C + Hyaluronic Acid | Tretinoin + Niacinamide | |
|---|---|---|
| Formula | Estriol / vitamin C / hyaluronic acid | Tretinoin / niacinamide / hyaluronic acid |
| Format | Topical cream | Topical cream |
| Ordering | Online plan selection | Online plan selection |
What to expect
The steps from choosing your plan to continuing your routine.
Getting started
Choose your plan
Compare the ingredients and the available purchase options.
After checkout
Follow your treatment plan
Use the instructions provided with your prescribed formulation.
Along the way
Keep in touch
Contact the existing care team with questions about your treatment or order.
HealthRX.com verified facts
Estriol / Vitamin C / Hyaluronic Acid online: price and access
Estriol / Vitamin C / Hyaluronic Acid starts at $158 per month on monthly plan; the lowest checkout charge is $158 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified October 3, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
Frequently asked questions
Which plan lengths can I choose?
This cream currently has a one-month option.
How do I choose between similar formulations?
Compare the ingredient lists and discuss your skin goals with your care team.
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Learn MoreAdd to your daily routine.
No prescription needed. Dietary supplements to keep alongside your skin care routine, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
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Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.