Dosed to the milligram
Compounded by a US-licensed pharmacy to your precise low dose, usually 1.5 to 4.5 mg.
- 30 capsulesSupply
- Provider reviewedBefore anything ships
- Free shippingPlain, unmarked box
The people pictured are models, not patients.
RxLongevity
Low Dose Naltrexone (LDN)
Low dose naltrexone, dosed to the milligram.
40,000+ products sold · LegitScript certified
Naltrexone 1.5 to 4.5 mg in a capsule formulation. Explore opioid-receptor activity and the condition-specific research behind LDN.
Explore the ingredients and compare options →- Compounded to your dose
- One nightly capsule
- Studied for inflammation
- Provider-titrated
What's Included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
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1-Month Plan
$161- $161 Billed Today
- Then $161 Every Month
- Cancel Anytime
Or pay with
$161 billed today, then every month until canceled.
Not prescribed? Full refund.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your low-dose naltrexone ships.
Full refund if not prescribed Free, discreet shipping Cancel anytime
Order today and here is what happens next
- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships in 3 to 5 daysEstimated ship date, if prescribed
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
What should I avoid when taking low dose naltrexone?
Avoid opioid medication, since naltrexone blocks opioid receptors. Tell your provider about every medication and supplement you take first.
What is low dose naltrexone used for?
It is prescribed off-label in protocols studied for inflammation, autoimmune conditions, chronic pain and wellbeing.
How does it work?
Research suggests a brief low-dose receptor blockade raises your own endorphins and calms inflammatory signaling, a different effect from full-dose naltrexone.
LegitScript certifiedCert. 50087439- US-licensed pharmacyPrepares every prescription
- Independent cliniciansUS-licensed, in your state
- 40,000+Products sold
- All 50 statesFree, discreet shipping
- No insurance requiredOne price, shown up front
Quiet evenings
Low dose naltrexone, dosed to the milligram.
- 01Compounded to your dose
- 02One nightly capsule
- 03Studied for inflammation
- 04Provider-titrated
The people pictured are models, not patients.
Why Low Dose Naltrexone (LDN)
One capsule at night
Taken once a day, most often at bedtime.
Studied for inflammation and immune balance
Small human trials have looked at low-dose naltrexone in fibromyalgia and Crohn's disease, summarized in the research section.
Provider-titrated
A US-licensed provider prescribes it off-label and steps your dose up gradually.
How we compare
Low Dose Naltrexone (LDN), without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Meet the formula
Understand what the “low dose” changes.
Low-dose naltrexone, usually shortened to LDN, describes a lower-dose formulation of naltrexone. The HealthRX.com catalog lists 1.5 to 4.5 mg capsules. Naltrexone is an opioid-receptor antagonist, meaning it blocks activity at opioid receptors. Researchers have explored lower-dose regimens in several conditions, with each study asking its own question. The useful product explanation connects the molecule, the dose context and the research endpoint, rather than using inflammation or recovery as an all-purpose label.
01
Ingredient
Naltrexone, an opioid-receptor antagonist
02
Dose context
Lower-dose formulation; catalog range 1.5 to 4.5 mg
03
Research question
The condition, symptom and measured outcome
Inside the formula
The names on the label, explained.
1.5 to 4.5 mg catalog range
Naltrexone
The word low describes the dosing context of an established medication. It is not a separate molecule or a new ingredient family. Conventional naltrexone products and lower-dose formulations share the active ingredient while using different amounts and clinical contexts. This capsule listing identifies the lower-dose range; research on a particular regimen belongs to that exact study, population and outcome.
A closer look / 01
Opioid receptors give the ingredient its identity.
Opioid receptors are part of the body’s signaling systems. An antagonist acts by blocking receptor activity, which is the pharmacologic starting point for understanding naltrexone. Lower-dose research also discusses proposed mechanisms beyond the conventional dosing context. An established receptor action and a proposed explanation for a particular use are different levels of evidence, so they deserve distinct treatment in a clear product guide.
That distinction helps keep the page useful. Knowing the ingredient family explains what naltrexone is. Knowing the strength and formulation explains the product. Naming the target symptom explains what a treatment discussion is trying to assess. Those three pieces make a more specific story than assigning every lower-dose use the same recovery promise.
A closer look / 02
Research is organized around conditions and endpoints.
Published LDN studies include fibromyalgia and Crohn’s disease. A pain trial and an intestinal-disease trial measure different outcomes, even when both use naltrexone. Fibromyalgia research has evaluated pain scores and related symptom measures; Crohn’s research has used clinical and intestinal-disease assessments. These are separate research settings rather than one general wellness outcome.
The findings also differ across studies. A 2024 randomized fibromyalgia trial of 6 mg daily did not show superiority over placebo for its primary pain outcome. Earlier work has examined other doses and designs. The exact regimen, the comparison group and the endpoint are all useful details when interpreting this evolving research area.
A closer look / 03
Read the capsule listing without collapsing the numbers.
The catalog range is 1.5 to 4.5 mg, with a 30-capsule listing. Strength describes the amount of active ingredient in a formulation; quantity describes the number of capsules in the catalog option. A range identifies the listed product strengths, while the selected prescribed formulation provides the specific product context. Comparing those details is more informative than reading “low dose” alone.
A closer look / 04
Make the treatment goal concrete.
A useful personal record names the symptom being followed and how it is observed. Pain intensity, sleep quality, fatigue and day-to-day function describe different experiences. Following the same measure consistently makes a change easier to describe. It also keeps a goal tied to the relevant research question instead of assuming improvement in one observation means improvement in every related concern.
Make an informed comparison
Compare the actual ingredients and formats.
These options have different active ingredients and mechanisms. LDN is a lower-dose naltrexone formulation; rapamycin is an mTOR-pathway medication; metformin is a biguanide. Their shared location in the longevity catalog is a browsing category, while their product identities remain distinct.
| Option | Ingredient identity | What distinguishes it |
|---|---|---|
| Low Dose Naltrexone | Naltrexone | Opioid-receptor antagonist; capsule formulation |
| Rapamycin | Sirolimus | mTOR inhibition; capsule formulation |
| Metformin ER | Metformin | Glucose-regulation pharmacology; ER tablet |
The useful details
A few questions worth answering.
Is LDN a supplement?
LDN contains naltrexone, a medication ingredient. The lower-dose description refers to its formulation context. It does not change the molecule into a vitamin, mineral or nutritional supplement. The active name and the exact strength make that identity clear.
Why do different LDN studies use different doses?
Researchers choose a regimen for the question and population being studied. A study at 6 mg and a catalog range of 1.5 to 4.5 mg describe different dose contexts. Following those details keeps a study result attached to the regimen that produced it.
Explore the ingredient research
Follow the sources.
See the available product options.
View optionsHealthRX.com verified facts
Low Dose Naltrexone (LDN) online: price and access
Low Dose Naltrexone (LDN) starts at $129 per month on 12-month plan; the lowest checkout charge is $161 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified August 26, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A US-licensed provider reviews your history and, if appropriate, prescribes a low starting dose off-label.
Ships to your door
Your exact dose is compounded and ships to your door in 3 to 5 days.
Ongoing support
Step up gradually and message your provider along the way.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
About Low Dose Naltrexone (LDN)
Full-dose naltrexone blocks opioid receptors. A small fraction of that dose is studied for a different effect: a brief blockade that may prompt your body to raise its own endorphins and calm inflammatory signaling. Your provider starts you low and adjusts over time, and the pharmacy compounds your exact dose.
- Compounded to your precise low dose
- Studied for inflammation and immune balance
- One capsule a day, usually at night
- Real pricing up front, message your provider anytime
Naltrexone is an opioid receptor antagonist, used off-label at low doses. Compounded by a US-licensed pharmacy.
A brief receptor block
At low doses, naltrexone briefly blocks opioid receptors for a few hours.
An endorphin rebound
Your body responds by raising its own endorphins.
Calmer immune signaling
Low-dose naltrexone is also thought to quiet inflammatory signaling from immune cells called microglia.
A short blockade that may prompt your own endorphins and calm inflammatory signaling. The mechanism is still being studied.
What the research shows
Naltrexone is an established opioid antagonist, and at very low doses it is prescribed off-label for inflammation and immune balance. The human evidence comes from small trials, summarized below. These studies are early and modest in size rather than large confirmatory trials.
28.8% vs 18.0%
Reduction in daily pain with low-dose naltrexone versus placebo in a double-blind crossover trial of 31 women with fibromyalgia.
Younger et al., Arthritis and Rheumatism, 2013
88% vs 40%
Clinical response in active Crohn's disease with low-dose naltrexone versus placebo in a randomized trial of 40 adults.
Smith et al., Digestive Diseases and Sciences, 2011
Low-dose naltrexone (1.5 to 4.5 mg) or Standard naltrexone (50 mg)
Low dose is a different tool from standard naltrexone
| Low-dose naltrexone (1.5 to 4.5 mg) | Standard naltrexone (50 mg) | |
|---|---|---|
| Dose | 1.5 to 4.5 mg | 50 mg |
| Opioid receptor block | Brief and partial | Full and all day |
| Typical use | Inflammation and immune balance, off-label | Opioid and alcohol use disorder |
| When taken | At night | Once daily, any time |
| Form | Compounded to your dose | Standard tablet |
| Goal | Endorphin rebound | Sustained opioid blockade |
What to expect
Vivid dreams or lighter sleep can show up early and usually settle. Your provider tracks your response over the following weeks.
Week 1 to 2
Start at 1.5 mg
Begin at the lowest dose, taken at night.
Week 2 to 4
Settle your sleep
Vivid dreams or lighter sleep can show up early and usually settle; some take the dose earlier in the evening.
Week 4 to 8
Titrate up
Your provider steps the dose toward 3 to 4.5 mg as you tolerate it.
Ongoing
Find your dose
Your provider tunes the dose to how you respond.
Safety and side effects
Not prescribed with opioid medication. Your provider reviews everything you take first and starts you low.
Common
- Vivid dreams
- Lighter or disrupted sleep
- Mild headache
- Nausea
Less common
- Daytime fatigue or grogginess
- Dizziness
- Stomach cramps or diarrhea
Seek care
- Opioid withdrawal if you are taking or recently took opioids
- Loss of effect from opioid pain medicines, which matters in an emergency or before surgery
Do not take low-dose naltrexone with opioid pain medication. It can block those medicines and, if you have opioids in your system, bring on withdrawal. Tell any provider or surgeon that you take it before procedures.
Frequently asked questions
Why is it taken at night?
It is usually dosed at night to match your overnight endorphin rhythm, though your provider can adjust timing.
Other longevity options
Everyday essentials for your routine.
No prescription needed. Dietary supplements for the daily habits around your care, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Choose a planNo insurance required
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.