A peptide your body already makes
MOTS-c is encoded in the DNA of your mitochondria, the parts of your cells that make energy. Researchers first described it in 2015.
- 5 mL vialSupply
- MOTS-c acetateStrength
- Provider reviewedBefore anything ships
The people pictured are models, not patients.
RxLongevity
MOTS-c
The mitochondrial peptide, by prescription.
40,000+ products sold · LegitScript certified
MOTS-c is a 16-amino-acid peptide your own mitochondria make. Since October 2026, US 503A pharmacies can compound it by prescription. A licensed provider reviews you first, then the pharmacy makes it for you by name and cold-ships it to your door.
- A mitochondrial peptide
- Single ingredient
- Provider reviewed
- Ships cold-packed
What's Included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
This medication is prepared by a licensed compounding pharmacy. Compounded medications are not reviewed by the FDA for safety or effectiveness and are dispensed only after a licensed provider determines they are appropriate for you.
How Would You Like To Pay?
Choose Your Plan
1-Month Plan
$134- $134 Billed Today
- Then $134 Every Month
- Cancel Anytime
Or pay with
$134 billed today, then every month until canceled.
Not prescribed? Full refund.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your MOTS-c ships.
Full refund if not prescribed Free, discreet shipping Cancel anytime
Order today and here is what happens next
- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships in 3 to 5 daysEstimated ship date, if prescribed
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
Is this the same MOTS-c sold on research sites?
Same peptide, very different product. Research sites sell vials labeled not for human use, often made overseas, with no one checking whether it fits you. Ours is compounded by a state-licensed US 503A pharmacy from a prescription written for you, with your name and directions on the label.
Is MOTS-c legal to prescribe now?
Yes, under conditions. In October 2026, HHS said it will not take enforcement action against state-licensed 503A pharmacies that compound MOTS-c from a patient-specific prescription and meet the policy's conditions, while FDA finishes its rule. It is still not FDA approved.
How much does MOTS-c cost?
Every plan price is on this page before you pay, and longer plans cost less per month. Each plan covers the online provider visit, the medication if prescribed and shipping. If the provider decides it is not right for you, you get a full refund.
LegitScript certifiedCert. 50087439- US-licensed pharmacyPrepares every prescription
- Independent cliniciansUS-licensed, in your state
- 40,000+Products sold
- All 50 statesFree, discreet shipping
- No insurance requiredOne price, shown up front
Early walks
The mitochondrial peptide, by prescription.
- 01A mitochondrial peptide
- 02Single ingredient
- 03Provider reviewed
- 04Ships cold-packed
The people pictured are models, not patients.
Why MOTS-c
Studied with exercise and metabolism
In people, exercise raised MOTS-c in muscle and blood. In mice, it was studied for metabolism and physical capacity.
Pharmacy-made, one ingredient
MOTS-c acetate, the form HHS names, compounded for you by a state-licensed US 503A pharmacy after a provider review.
Price up front, refund if not prescribed
See every price before you pay. If your provider says no, you get a full refund.
How we compare
MOTS-c, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Understand your treatment
A peptide from your mitochondria.
Most of your DNA sits in the cell nucleus, but mitochondria carry their own small genome. MOTS-c is one of the few peptides encoded there. Research has looked at it in metabolism and exercise, mostly in mice, and US 503A pharmacies can now compound it by prescription.
A closer look
A peptide from your mitochondria.
Mitochondrial DNA
16 amino acids
Skeletal muscle
Make a more informed choice
MOTS-c vs. a metabolism supplement
MOTS-c is a prescription peptide that a provider reviews and a pharmacy compounds for you. Over-the-counter supplements are a different category with different rules.
Explore the ingredient research
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454.
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470.
- HHS. Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances, Appendices A and B. October 2026.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A US-licensed provider reviews your intake and prescribes MOTS-c only if it is right for you.
Ships to your door
A state-licensed US 503A pharmacy makes it for you by name and ships it free in plain packaging, cold-packed.
Ongoing support
Message your care team with questions. Your provider can adjust or stop your plan.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
About MOTS-c
MOTS-c is a peptide of 16 amino acids encoded in mitochondrial DNA, inside the 12S rRNA gene. In mouse studies its main target was skeletal muscle, where it activated AMPK, a cellular energy sensor. Your vial holds MOTS-c acetate as the only active ingredient, compounded by a US 503A pharmacy.
- A 16-amino-acid mitochondrial peptide
- MOTS-c acetate, the only active ingredient
- Injected under the skin or into muscle, as your provider directs
- Prescribed after a US-licensed provider review
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (HHS Appendix B, 2026).
Mitochondrial DNA
a short reading frame in the 12S rRNA gene encodes MOTS-c
Skeletal muscle
its main target in mouse studies
AMPK
a cellular energy sensor it activated in those studies
A signal from your mitochondria, studied for metabolism and exercise.
What the research shows
MOTS-c research is mostly in mice, with early human data on exercise. Here is what it shows.
16
amino acids, encoded in mitochondrial DNA rather than in the cell nucleus.
Lee et al., Cell Metab 2015
In mice
MOTS-c treatment prevented diet-induced obesity and age-related insulin resistance.
Lee et al., Cell Metab 2015
In people
exercise raised MOTS-c levels in skeletal muscle and in the blood.
Reynolds et al., Nat Commun 2021
References
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454.
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470.
- HHS. Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances, Appendices A and B. October 2026.
HealthRX.com or Research-use sites
Two very different ways to get MOTS-c
| HealthRX.com | Research-use sites | |
|---|---|---|
| Who makes it | A state-licensed US 503A pharmacy, from your prescription | Often overseas labs, sold as powder in a vial |
| Labeled for | You, by name, with your provider's directions | "Research use only. Not for human use." |
| Who checks it fits you | A US-licensed provider reviews your health history | No one |
| What is in it | MOTS-c acetate, one ingredient | The seller's own claims |
| Questions later | Message your care team anytime | Seller support, if any |
| Price | Shown up front, full refund if not prescribed | Often less per vial, with no medical review |
What to expect
Here is how your first month goes, from checkout to your first refill.
Today
Choose a plan and do your intake
Checkout takes a few minutes, then a short online health intake.
Day 1 to 2
A provider reviews
A US-licensed provider reviews your intake and may message you with questions.
Within about a week
It arrives
If prescribed, the pharmacy ships it cold-packed in plain packaging, with your directions on the label.
Each month
Check in and refill
Message your care team anytime. Plans refill on schedule, and you can pause or cancel from your account.
Safety and side effects
MOTS-c is compounded by a US-licensed 503A pharmacy and is not FDA approved. FDA has not reviewed it for safety, effectiveness or quality, and human studies are small. A licensed provider reviews your health history and medicines before deciding whether to prescribe it. It is not for use during pregnancy or breastfeeding, or by anyone under 18. Report side effects to your provider, or to FDA MedWatch at 1-800-FDA-1088.
Common
- Redness, swelling or itching where you inject
- A small bruise at the injection site
Less common
- Soreness at the injection site that lasts more than a day
Seek care
- Signs of an allergic reaction: hives, swelling of the face or throat, or trouble breathing
- Signs of infection where you inject: spreading redness, warmth or fever
Human safety data for MOTS-c are limited. Tell your provider if you take medicine for diabetes or blood sugar. Tell your provider about every medicine you take before starting. This is not a complete list of side effects.
Frequently asked questions
How is MOTS-c taken?
It comes as an injectable vial. Your provider sets your dose and schedule, and the pharmacy label spells it out. Follow your prescription, not a dosing chart you find online.
What does the research on MOTS-c show?
In mice, MOTS-c treatment prevented diet-induced obesity and age-related insulin resistance (Lee et al., 2015) and improved physical capacity in young, middle-aged and old animals (Reynolds et al., 2021). In people, exercise raised the body's own MOTS-c in muscle and blood. Human trials of MOTS-c treatment are limited, and your provider will go through them with you.
Who should not take MOTS-c?
It is not for anyone pregnant, breastfeeding or under 18. Tell your provider if you take medicine for diabetes or blood sugar. Your provider reviews your health history and medicines before deciding.
How fast does it ship?
Usually 3 to 5 days after your provider approves it, cold-packed in a plain box. Shipping is free.
Can I pause or cancel?
Yes. Plans refill on their own schedule, and you can pause, change or cancel anytime from your account.
Other longevity options
Everyday essentials for your routine.
No prescription needed. Dietary supplements for the daily habits around your care, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Choose a planNo insurance required
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.