- LegitScript Certified
- US-licensed pharmacy
- Ships in 3 to 5 days
- Concentration
- Oxymetazoline 0.88% / Ivermectin 0.88% / Niacinamide 4%
- Purity
- Provider reviewed
- Unit
- 30g tube
- Category
- Prescription Skincare
Common questions
What is the best prescription cream for rosacea?
Does oxymetazoline reduce facial redness?
How is ivermectin used for rosacea?
Rosacea Cream (Oxymetazoline + Ivermectin)
For redness that will not settle.
Rosacea cream · Oxymetazoline / Ivermectin / Niacinamide
- Oxymetazoline for redness
- Ivermectin for bumps
- Two mechanisms, one cream
- Provider-reviewed
What's Included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
How Would You Like To Pay?
Choose Your Plan
1-Month Plan
$152- $152 Billed Today
- Then $152 Every Month
- Cancel Anytime
Or pay with
$152 billed today, then every month until canceled.
By completing your order, you agree to the HealthRX.com Terms & Conditions and Privacy Policy, and confirm you are 18 or older.
Your provider confirms the strength and dose after intake. Payment does not guarantee a prescription.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your rosacea cream ships.
HealthRX.com verified facts
Rosacea Cream (Oxymetazoline + Ivermectin) online: price and access
Rosacea Cream (Oxymetazoline + Ivermectin) starts at $122 per month on 12-month plan; the lowest checkout charge is $152 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified August 26, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A licensed physician (MD) reviews your completed intake and prescribes your cream if it is appropriate for you.
Ships to your door
A US-licensed pharmacy compounds your formula and ships it free in discreet packaging.
Ongoing support
Message your care team anytime, and your provider adjusts your plan as your skin responds.
Oxymetazoline calms visible redness
Oxymetazoline narrows the small blood vessels in your skin, the ones behind the persistent flushed look of rosacea.
Ivermectin targets the bumps
Ivermectin reduces the inflammatory papules and pustules of rosacea and acts on the Demodex mites linked to them.
Niacinamide steadies your barrier
Niacinamide 4% supports a calmer, more resilient skin barrier, which rosacea-prone skin often lacks.
A provider reviews your skin
A US-licensed provider confirms this cream is appropriate for your rosacea before it ships. Real pricing, shown up front.
About Rosacea Cream (Oxymetazoline + Ivermectin)
Rosacea shows up as two problems at once: persistent redness and inflammatory bumps. This cream pairs oxymetazoline, which constricts the dilated vessels behind flushing, with ivermectin, which targets the inflammation and mites tied to rosacea bumps. Your provider reviews your skin first. Compounded by a US-licensed pharmacy.
- Oxymetazoline for persistent redness
- Ivermectin for inflammatory bumps
- Two rosacea mechanisms in one cream
- Real pricing up front, discreet shipping
Oxymetazoline is an alpha-agonist that constricts facial blood vessels; ivermectin has anti-inflammatory and anti-parasitic activity; niacinamide supports the barrier. Compounded by a US-licensed pharmacy.
Oxymetazoline constricts vessels
It tightens the dilated facial blood vessels that make skin look flushed and red.
Ivermectin reduces inflammation
It lowers the inflammatory activity behind rosacea bumps and targets the Demodex mites linked to them.
Niacinamide supports the barrier
It helps calm reactivity and reinforce the skin barrier while the other actives work.
Redness can look calmer within hours while the bumps improve over several weeks.
What the research shows
The actives in your cream have each been studied on their own for rosacea. This exact compounded combination has not been tested as a single product, so the research below reflects the individual ingredients, studied at their own strengths.
40% vs 12%
Across two randomized, vehicle-controlled pivotal trials, ivermectin 1% cream cleared or nearly cleared rosacea in about 38 to 40 percent of patients, versus 12 to 19 percent on vehicle.
Stein et al., J Drugs Dermatol 2014
2-grade
In a randomized, vehicle-controlled pivotal trial, oxymetazoline cream produced at least a two-grade improvement in persistent facial redness significantly more often than vehicle by day 29.
Kircik et al., J Drugs Dermatol 2018
References
- Stein L, et al. Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies. J Drugs Dermatol. 2014;13(3):316-323.
- Kircik LH, et al. Pivotal trial of the efficacy and safety of oxymetazoline cream 1.0% for the treatment of persistent facial erythema associated with rosacea: findings from the first REVEAL trial. J Drugs Dermatol. 2018;17(1):97-105.
Compounded two-in-one cream or Single-active prescription cream
Two drivers of rosacea, or one
| Compounded two-in-one cream | Single-active prescription cream | |
|---|---|---|
| Targets visible redness | Yes, oxymetazoline | Only if that is the active |
| Targets bumps | Yes, ivermectin | Only if that is the active |
| Creams to apply | One | Often two separate products |
| Barrier support | Niacinamide included | Usually not |
| Provider oversight | Reviewed by a provider | Reviewed by a provider |
| Cost | One combined price | May be lower for a single active |
What to expect
Redness can look calmer within hours of application as vessels constrict; the bump-related improvement builds over several weeks.
Day 1
Start your cream
Apply a thin layer after your provider confirms your prescription. Redness can look calmer within hours as vessels constrict, and some mild stinging at first is normal.
Weeks 2 to 4
Bumps begin to settle
The inflammatory papules and pustules typically start to improve in this window with daily use.
Weeks 8 to 12
Fuller effect on bumps
Improvement in bumps tends to build further through the second and third months of consistent use.
Ongoing
Maintain your results
Your provider tunes your routine to keep redness and bumps controlled with the lowest effective schedule.
Safety and side effects
Reviewed by a licensed provider. Avoid the eyes. Tell your provider about other rosacea treatments you use.
Common
- Application-site irritation
- Dryness
- Stinging or burning on application
- Redness or warmth where applied
Less common
- Rebound redness or flushing as the cream wears off
- Itching or contact dermatitis
- Temporary worsening of rosacea symptoms
Seek care
- Severe allergic reaction
- Eye irritation or vision changes if the cream reaches the eyes
This is not a complete list of side effects. Apply only to your face and avoid the eyes, lips, and the inside of the nose. Some people notice redness returning as oxymetazoline wears off. This cream contains prescription actives and is used only under a provider's direction. Tell your provider about other rosacea treatments and every medication you use before starting.
Frequently asked questions
How fast does rosacea cream work?
Other prescription skincare options
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.