No needles
A nasal spray, 2.5 mg/mL in a 20 mL bottle. It is the only form HHS's policy covers for semax.
- 20 mL nasal spraySupply
- Semax 2.5 mg/mLStrengths
- Provider reviewedBefore anything ships
The people pictured are models, not patients.
RxLongevity
Semax Nasal Spray
Semax, as a prescription nasal spray.
40,000+ products sold · LegitScript certified
Semax is a seven-amino-acid peptide built from a fragment of the hormone ACTH. HHS covers it as a nasal spray only, and that is how ours comes: no needles, compounded by a US 503A pharmacy and prescribed after a licensed provider review.
- Nasal spray, no needles
- Single ingredient
- Provider reviewed
- Free shipping
What's Included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
This medication is prepared by a licensed compounding pharmacy. Compounded medications are not reviewed by the FDA for safety or effectiveness and are dispensed only after a licensed provider determines they are appropriate for you.
How Would You Like To Pay?
Choose Your Plan
1-Month Plan
$134- $134 Billed Today
- Then $134 Every Month
- Cancel Anytime
Or pay with
$134 billed today, then every month until canceled.
Not prescribed? Full refund.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your semax ships.
Full refund if not prescribed Free, discreet shipping Cancel anytime
Order today and here is what happens next
- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships in 3 to 5 daysEstimated ship date, if prescribed
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
Is this the same semax sold on research sites?
Same peptide, very different product. Research sites sell vials labeled not for human use, often made overseas, with no one checking whether it fits you. Ours is compounded by a state-licensed US 503A pharmacy from a prescription written for you, with your name and directions on the label.
Is semax legal to prescribe now?
Yes, under conditions. In October 2026, HHS said it will not take enforcement action against state-licensed 503A pharmacies that compound semax from a patient-specific prescription and meet the policy's conditions, while FDA finishes its rule. HHS covers it as a nasal spray only. It is still not FDA approved.
How much does Semax cost?
Every plan price is on this page before you pay, and longer plans cost less per month. Each plan covers the online provider visit, the medication if prescribed and shipping. If the provider decides it is not right for you, you get a full refund.
LegitScript certifiedCert. 50087439- US-licensed pharmacyPrepares every prescription
- Independent cliniciansUS-licensed, in your state
- 40,000+Products sold
- All 50 statesFree, discreet shipping
- No insurance requiredOne price, shown up front
Focused mornings
Semax, as a prescription nasal spray.
- 01Nasal spray, no needles
- 02Single ingredient
- 03Provider reviewed
- 04Free shipping
The people pictured are models, not patients.
Why Semax Nasal Spray
Built from ACTH
Seven amino acids: a short fragment of the hormone ACTH (4 to 7) with a Pro-Gly-Pro tail added.
Studied for BDNF
In rats, a single dose raised BDNF, a growth factor for nerve cells, in the hippocampus.
Price up front, refund if not prescribed
See every price before you pay. If your provider says no, you get a full refund.
How we compare
Semax Nasal Spray, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Understand your treatment
A peptide you spray, not inject.
Semax was developed in Russia from a short fragment of the hormone ACTH. Research has focused on the brain, including BDNF in animal studies. HHS covers semax only as a nasal spray, which is the form we offer.
A closer look
A peptide you spray, not inject.
ACTH (4-7) + Pro-Gly-Pro
BDNF
Nasal spray
Make a more informed choice
Nasal spray vs. injection
Many peptides come as injectable vials. HHS covers semax for nasal use only, so there are no needles: a spray on the schedule your provider sets.
Explore the ingredient research
- Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60.
- HHS. Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances, Appendices A and B. October 2026.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A US-licensed provider reviews your intake and prescribes semax only if it is right for you.
Ships to your door
A state-licensed US 503A pharmacy makes it for you by name and ships it free in plain packaging.
Ongoing support
Message your care team with questions. Your provider can adjust or stop your plan.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
About Semax Nasal Spray
Semax is a synthetic peptide of seven amino acids (Met-Glu-His-Phe-Pro-Gly-Pro): the ACTH (4 to 7) fragment with a Pro-Gly-Pro tail added. It was developed in Russia, and research has focused on the brain, including BDNF in animal studies. Yours is a nasal spray, 2.5 mg/mL in a 20 mL bottle, with semax as the only active ingredient.
- A seven-amino-acid synthetic peptide
- Semax is the only active ingredient
- A nasal spray, no needles
- Prescribed after a US-licensed provider review
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (HHS Appendix B, 2026). Spray: 2.5 mg/mL, 20 mL bottle.
ACTH (4 to 7)
Met-Glu-His-Phe, a short fragment of the hormone ACTH
Pro-Gly-Pro
three amino acids added to the end
BDNF
a growth factor for nerve cells that semax raised in rat studies
A seven-amino-acid peptide, given as a nasal spray.
What the research shows
Semax research is mostly animal work and studies from Russia. Here is what the record shows.
7
amino acids make up semax: Met-Glu-His-Phe-Pro-Gly-Pro.
Dolotov et al., Brain Res 2006
1.4x
the BDNF protein level in the rat hippocampus after a single dose of semax, at its peak.
Dolotov et al., Brain Res 2006
Nasal
is the only route HHS's policy covers for semax.
HHS 503A peptide policy, 2026
References
- Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60.
- HHS. Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances, Appendices A and B. October 2026.
HealthRX.com or Research-use sites
Two very different ways to get semax
| HealthRX.com | Research-use sites | |
|---|---|---|
| Who makes it | A state-licensed US 503A pharmacy, from your prescription | Often overseas labs, sold as powder in a vial |
| Labeled for | You, by name, with your provider's directions | "Research use only. Not for human use." |
| Who checks it fits you | A US-licensed provider reviews your health history | No one |
| What is in it | Semax, one ingredient | The seller's own claims |
| Questions later | Message your care team anytime | Seller support, if any |
| Price | Shown up front, full refund if not prescribed | Often less per vial, with no medical review |
What to expect
Here is how your first month goes, from checkout to your first refill.
Today
Choose a plan and do your intake
Checkout takes a few minutes, then a short online health intake.
Day 1 to 2
A provider reviews
A US-licensed provider reviews your intake and may message you with questions.
Within about a week
It arrives
If prescribed, the pharmacy ships it in plain packaging, with your directions on the label.
Each month
Check in and refill
Message your care team anytime. Plans refill on schedule, and you can pause or cancel from your account.
Safety and side effects
Semax is compounded by a US-licensed 503A pharmacy and is not FDA approved. FDA has not reviewed it for safety, effectiveness or quality, and human studies are small. A licensed provider reviews your health history and medicines before deciding whether to prescribe it. It is not for use during pregnancy or breastfeeding, or by anyone under 18. Report side effects to your provider, or to FDA MedWatch at 1-800-FDA-1088.
Common
- Nasal irritation or dryness
- A runny nose
Less common
- Irritation that does not settle after a few days
Seek care
- Signs of an allergic reaction: hives, swelling of the face or throat, or trouble breathing
Human safety data for semax are limited. Tell your provider about every medicine you take before starting. This is not a complete list of side effects.
Frequently asked questions
How is semax taken?
It is a nasal spray. Your provider sets how many sprays and how often, and the pharmacy label spells it out. Follow your prescription, not a dosing chart you find online.
What does the research on semax show?
In rats, a single dose of semax raised BDNF, a growth factor for nerve cells, in the hippocampus (Dolotov et al., 2006). Much of the human research comes from Russia, where semax was developed. Your provider will go through what is and is not known.
Who should not take Semax?
It is not for anyone pregnant, breastfeeding or under 18. Your provider reviews your health history and medicines before deciding.
How fast does it ship?
Usually 3 to 5 days after your provider approves it, in a plain box. Shipping is free.
Can I pause or cancel?
Yes. Plans refill on their own schedule, and you can pause, change or cancel anytime from your account.
Other longevity options
Everyday essentials for your routine.
No prescription needed. Dietary supplements for the daily habits around your care, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Choose a planNo insurance required
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.