One dose, up to 36 hours
Tadalafil has a long half-life, so a single as-needed dose can keep you covered for up to a day and a half. Intimacy does not have to be timed to the minute.
- 10 doses/monthSupply
- 10mg / 20mgStrengths
- Provider reviewedBefore anything ships
The people pictured are models, not patients.
RxSexual Health
Tadalafil
Up to 36 hours in your system, at either strength.
40,000+ products sold · LegitScript certified
Tadalafil's 17.5-hour half-life gives this dose a window of activity that can run up to 36 hours, in 10mg or 20mg. A board-certified physician confirms the strength that's clinically appropriate for you before it ships.
- Up to 36 hour window
- Works with food
- Take as needed
- Oral tablet
What's Included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
Strength
Doses per month
How Would You Like To Pay?
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1-Month Plan
$7110mg · 10 doses/mo
- $71 Billed Today
- Then $71 Every Month
- Cancel Anytime
Or pay with
$71 billed today, then every month until canceled.
Not prescribed? Full refund.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before any tadalafil ships.
Full refund if not prescribed Free, discreet shipping Cancel anytime
Order today and here is what happens next
- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships in 3 to 5 daysEstimated ship date, if prescribed
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
Is 10mg or 20mg the right starting dose?
10mg is the standard starting point for as-needed use. Your provider moves you to 20mg, the maximum approved as-needed dose, only if 10mg doesn't produce an adequate response. Both strengths share the same 36-hour window and arousal requirement; 20mg simply delivers more active drug for people who need it.
Does 20mg last longer than 10mg?
No. Both strengths share the same roughly 17.5-hour half-life and the same up-to-36-hour window. Strength affects how much active drug is available and how pronounced the effect and side effects can feel, not how long tadalafil stays active in your system.
Why do people call tadalafil the weekend pill?
The nickname comes from its roughly 36-hour window, long enough to cover a Friday night through Sunday without a second dose, at either 10mg or 20mg. It's the identical medication used in the daily formulation, just prescribed on an as-needed schedule instead of a continuous one. Your provider can help you decide which schedule fits how you actually use it.
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Evenings at home
Up to 36 hours in your system, at either strength.
- 01Up to 36 hour window
- 02Works with food
- 03Take as needed
- 04Oral tablet
The people pictured are models, not patients.
Why Tadalafil
Works with or without food
Unlike sildenafil, tadalafil absorption is not affected by meals, so a heavy dinner will not change how it works.
The active ingredient in Cialis
Tadalafil is the same active ingredient found in branded Cialis, compounded by a US-licensed pharmacy at 10 mg or 20 mg.
A provider reviews you first
A US-licensed provider checks your health history and heart risks before prescribing. Real pricing, shown up front.
How we compare
Tadalafil, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Understand your treatment
More flexibility around the moment.
Tadalafil is a PDE5 inhibitor, the same medication class as sildenafil, with a longer duration of action. The as-needed tablets on this page are distinct from the lower-strength daily tadalafil option. That distinction matters more than the brand name: one approach plans around an occasion, while the other creates a regular medication routine. The product page and plan picker show which strengths belong to this particular option.
A closer look
More flexibility around the moment.
PDE5 inhibition
Longer activity window
As-needed tablets
Make a more informed choice
As-needed tadalafil vs. daily tadalafil
The active ingredient is the same. The strength and schedule differ. Compare the as-needed 10 mg or 20 mg option here with the separate 2.5 mg or 5 mg daily listing.
Explore the ingredient research
- Brock GB, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002;168(4 Pt 1):1332-1336.
- Porst H, et al. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Urology. 2003;62(1):121-125.
HealthRX.com verified facts
Tadalafil online: price and access
Tadalafil starts at $42 per month on 12-month plan; the lowest checkout charge is $53 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified August 26, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A US-licensed provider reviews your history and prescribes tadalafil if it is appropriate for you.
Ships to your door
A US-licensed pharmacy compounds your dose and ships it free in discreet packaging.
Ongoing support
Message your care team anytime, and your provider can move you between 10 mg and 20 mg based on how you respond.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
About Tadalafil
Tadalafil works through the same PDE5 mechanism as sildenafil, but its pharmacokinetics differ in one important way: a half-life of roughly 17.5 hours, compared with a few hours for sildenafil, which is what stretches its window of activity out to as long as 36 hours at either strength. Like every PDE5 inhibitor, tadalafil requires sexual arousal to work, so the extended window changes how long the option stays available in your system, not whether stimulation is still necessary. 20mg delivers more active drug than 10mg for people who need a stronger response, and clinical evidence shows no benefit from exceeding 20mg on an as-needed basis.
- Roughly 36 hours of coverage from one dose, well beyond sildenafil's four-to-six-hour range
- Absorption unaffected by meal timing, unlike sildenafil
- 20mg available in your file if 10mg doesn't produce enough of a response, with no benefit past it
- Approved by the FDA in 2003, extending the PDE5 inhibitor class beyond sildenafil alone
- Scheduling flexibility for people who'd rather not plan around one fixed hour
Arousal releases nitric oxide
Sexual stimulation signals the release of nitric oxide, which raises cGMP in the smooth muscle of the penis.
Tadalafil blocks the PDE5 enzyme
PDE5 normally breaks cGMP down. Tadalafil inhibits it, and its long half-life keeps levels up for many hours.
Smooth muscle relaxes, blood flows in
The vessels widen and blood fills the erectile tissue, supporting a firmer erection.
More blood flow during arousal across a long window, and sexual stimulation is still required.
What the research shows
Tadalafil has been evaluated in randomized controlled trials for erectile dysfunction, including its long duration of action. Here is what that research found.
81% versus 35%
of men reported improved erections on tadalafil compared with placebo in pooled randomized trials.
Brock et al., J Urol 2002
Effective at 36 hours
about 59 percent of attempts succeeded a day and a half after a single dose, versus 28 percent on placebo.
Porst et al., Urology 2003
As needed, by mouth
An oral tablet taken ahead of time and unaffected by food, with no injections or in-office visits required.
References
- Brock GB, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002;168(4 Pt 1):1332-1336.
- Porst H, et al. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Urology. 2003;62(1):121-125.
Tadalafil as needed or Tadalafil daily
Two ways to take tadalafil
| Tadalafil as needed | Tadalafil daily | |
|---|---|---|
| How you take it | A dose before intimacy | One low dose every day |
| Spontaneity | Up to a 36 hour window | Always ready, no timing |
| Strength | 10 mg or 20 mg | 2.5 mg or 5 mg |
| If sex is infrequent | Only take it when you want it | Taken every day regardless |
| If sex is frequent | Redose to stay covered | Steady coverage without planning |
| Active ingredient | Same as branded Cialis | Same as branded Cialis for daily use |
What to expect
Onset typically falls between thirty and sixty minutes, with concentration peaking around the two-hour mark, later than sildenafil's roughly one-hour peak, the same timeline at 10mg or 20mg. Unlike sildenafil, absorption isn't meaningfully affected by food, so timing doesn't depend on when you last ate. From there, the effect can persist for up to 36 hours, which is why some clinicians describe it as extended-coverage dosing rather than single-event dosing. 20mg is generally reserved for people whose response to 10mg wasn't strong enough, and the documented side-effect profile can run somewhat more pronounced at that dose: nasal congestion, muscle or back aches, indigestion, flushing, and headache.
30 to 60 minutes
It takes effect
Take one tablet ahead of intimacy, and food does not need to be timed around it.
2 to 24 hours
Your window opens
Tadalafil stays effective across a long window, so intimacy does not have to be scheduled tightly.
Up to 36 hours
Still covered
A single dose can remain effective up to a day and a half later, with arousal still required.
After a few tries
Dial in your dose
Your provider can adjust between 10 mg and 20 mg based on how you respond.
Safety and side effects
Nitrates and alpha-blockers are both absolute contraindications with tadalafil at either strength; combining either can send your blood pressure to unsafe lows. Your provider also checks for cardiovascular disease, uncontrolled blood pressure, and liver or kidney impairment before prescribing, since reduced organ function changes how tadalafil clears from your body. Side effects can run somewhat more pronounced at 20mg than at 10mg.
Common
- Headache
- Flushing
- Indigestion
- Back pain or muscle aches
Less common
- Nasal congestion
- Changes in vision
- Dizziness
Seek care
- An erection lasting more than four hours, called priapism, which needs emergency care
- Sudden loss of vision or hearing, or chest pain, seek care right away
This is not a complete list of side effects. Never take tadalafil with nitrate medications such as nitroglycerin, or with recreational poppers, because the combination can cause a dangerous drop in blood pressure. Tell your provider about alpha-blockers, heart conditions, and every medication you take. Tadalafil is not for use by women or by anyone under 18.
Frequently asked questions
Does eating affect how tadalafil works?
No, and that's one of its clinical advantages over sildenafil. Absorption isn't meaningfully slowed by food, so you can take it with a full meal, an empty stomach, or moderate alcohol without changing onset time, which still falls in the thirty-to-sixty-minute range regardless of strength or what you ate.
Other sexual health options
Prescription Arousal Cream
Aminophylline / Ergoloid / Pentoxifylline / Sildenafil
From $143/mo
Learn More
Oxytocin Nasal Spray
Oxytocin 100 IU/mL
From $165/mo
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TEMPO 4-in-1
Apomorphine / Sildenafil / Tadalafil / Vardenafil
From $88/mo
Learn More
Sildenafil
50mg / 100mg
From $35/moabout $6/dose
Learn MoreApproval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Choose a planNo insurance required
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.