Three ingredients in a nasal format.
Tadalafil 50 mg/mL, oxytocin 600 IU/mL and PT-141 2.5 mg/mL in one nasal blend. Meet each ingredient and compare the formulation with tablets and single-ingredient products.
Explore the ingredients and compare options →Pause, change, or cancel anytime from your account.
How Would You Like To Pay?
Choose Your Plan
Or pay with
$218 billed today, then every month until canceled.
By completing your order, you agree to the HealthRX.com Terms & Conditions and Privacy Policy, and confirm you are 18 or older.
Your provider confirms the strength and dose after intake. Payment does not guarantee a prescription.
Meet the formula
This formula combines a PDE5 inhibitor with two peptides in a nasal format. Tadalafil supplies the PDE5 component, oxytocin supplies oxytocin-receptor signaling, and PT-141 supplies melanocortin-receptor activity. The useful explanation is the role of each ingredient, rather than treating “three in one” as a measure of strength. These are different pharmacologic families brought into one formulation, with concentrations that identify this specific product.
Tadalafil and the cGMP blood-flow signal
Peptide signaling at oxytocin receptors
PT-141, also called bremelanotide
Inside the formula
50 mg/mL
Tadalafil inhibits phosphodiesterase type 5, or PDE5. This enzyme breaks down cGMP, a messenger involved in smooth-muscle relaxation during an erectile response. Tadalafil is also available in separate oral products. Here it is one ingredient in a nasal blend, so the ingredient name identifies the molecule while the complete listing identifies the formulation.
600 IU/mL
Oxytocin is a peptide hormone with roles in social and reproductive signaling. It acts through oxytocin receptors, a different target from PDE5. Its inclusion gives the blend an ingredient from that signaling family. The oxytocin concentration here also differs from the oxytocin-only nasal listing, which contains 100 IU/mL.
2.5 mg/mL
PT-141 is also called bremelanotide. It is a melanocortin-receptor agonist, meaning it activates receptors in that family. Published bremelanotide research includes a subcutaneous injectable formulation. The molecule helps explain this ingredient’s receptor target; the nasal route helps explain why this is a distinct product from an injectable PT-141 listing.
A closer look / 01
Tadalafil and PT-141 are listed in milligrams per milliliter. Oxytocin is listed in international units per milliliter. Milligrams describe mass; international units describe biological activity using an ingredient-specific standard. The three numbers therefore cannot be added into a single potency score. Each concentration tells you something about its own ingredient within the blend.
A concentration also differs from the amount delivered on an occasion. The volume delivered and the prescribed product instructions complete that picture. The catalog’s three concentration values identify the formula being compared, without requiring you to treat a spray as an oral tablet or transfer an injectable schedule to it.
A closer look / 02
A nasal spray, swallowed tablet and injection are separate formulations. Delivery affects the context in which an ingredient is used and studied. For example, tadalafil’s oral-product research and bremelanotide’s injectable-product research explain their ingredient families, while this listing combines them with oxytocin in a nasal product. Comparing the actual route alongside the active ingredients makes the product choice much more concrete.
A closer look / 03
PDE5 research concerns a blood-flow signaling pathway. Oxytocin studies have explored sexual function and partner interaction. Bremelanotide studies have explored sexual desire using their own patient populations and endpoints. Reading these as three research strands gives each ingredient a clear identity. It also avoids treating separate studies as a clinical trial of this finished three-ingredient nasal formulation.
Make an informed comparison
Start with the full formula and the route. A tadalafil tablet offers one ingredient in an oral product. An oxytocin-only spray offers one peptide in a nasal product. This listing combines three active ingredients across three receptor or enzyme targets.
| Option | Ingredient identity | What distinguishes it |
|---|---|---|
| This nasal blend | Tadalafil / oxytocin / PT-141 | Three pathways; nasal formulation |
| Oxytocin Nasal Spray | Oxytocin 100 IU/mL | Single-ingredient nasal formulation |
| Tadalafil | Tadalafil | Single-ingredient oral tablet |
| PT-141 | Bremelanotide | Injectable peptide formulation |
The useful details
The ingredient list describes the design of the formulation. Understanding each target explains why the ingredients are different. A particular experience or result is a separate question from identifying those targets, and studies of individual products use their own routes, doses and outcomes.
TEMPO contains apomorphine, sildenafil, tadalafil and vardenafil in a sublingual format. This nasal blend contains tadalafil, oxytocin and PT-141. Tadalafil is the shared ingredient; the other ingredients, pharmacologic groups and delivery format differ.
Explore the ingredient research
See the available product options.
View options
Choose your treatment options and complete secure checkout. Then complete the online health intake.
A licensed provider reviews your health history and determines whether this treatment is appropriate for you.
If prescribed, a US-licensed pharmacy prepares and ships your medication.
Contact the care team with questions about your treatment or order.
Tadalafil, oxytocin and PT-141 in the verified nasal formulation.
A different route from oral tablets and standalone injections.
One-, three-, six- and twelve-month options are available.
Use the existing subscription or one-time purchase selector to choose how you order.
This nasal spray combines tadalafil, oxytocin and PT-141 in a single formulation. It provides a different route and ingredient combination from oral tadalafil or a standalone PT-141 injection. Choose a one-, three-, six- or twelve-month plan using the same plan picker as the other HealthRX.com treatments.
Tadalafil
One of three ingredients in the nasal formulation.
Oxytocin
The second ingredient, specified in IU/mL.
PT-141
The third ingredient, also known as bremelanotide.
Oxytocin has been studied separately through the nasal route. The trial below evaluated oxytocin alone in healthy men, rather than this three-ingredient combination.
103 participants
This randomized study evaluated intranasal oxytocin in healthy men.
Walch et al., 2001
No detectable difference
The study found no detectable effect on ejaculation time or seminal parameters.
Walch et al., 2001
Compare the ingredients and format before choosing your plan.
| Tadalafil + Oxytocin + PT-141 Nasal Spray | Tadalafil Tablets | |
|---|---|---|
| Formula | Tadalafil / oxytocin / PT-141 nasal spray | Tadalafil oral tablet |
| Format | Nasal spray | Oral tablet |
| Ordering | Online plan selection | Online plan selection |
The steps from choosing your plan to continuing your routine.
Getting started
Compare the ingredients and the available purchase options.
After checkout
Use the instructions provided with your prescribed formulation.
Along the way
Contact the existing care team with questions about your treatment or order.
HealthRX.com verified facts
Tadalafil / Oxytocin / PT-141 Nasal Spray starts at $110 per month on 12-month plan; the lowest checkout charge is $218 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified October 3, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.
