The fragment HHS names
TB-500 is Ac-LKKTETQ, seven amino acids from the actin-binding region of thymosin beta-4. It is not the full 43-amino-acid protein.
- Injectable vialSupply
- TB-500 acetateStrength
- Provider reviewedBefore anything ships
The people pictured are models, not patients.
RxLongevity
TB-500
TB-500 by prescription. Coming soon.
40,000+ products sold · LegitScript certified
TB-500 is a seven-amino-acid fragment of thymosin beta-4. HHS opened it to US 503A pharmacies in October 2026, as an injection under the skin or into muscle. Our pharmacy is adding it as a single-ingredient prescription. Join the list to be first.
- Coming soon
- Single ingredient
- Provider reviewed
- Free to join the list
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- Independent cliniciansUS-licensed, in your state
- 40,000+Products sold
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- No insurance requiredOne price, shown up front
Morning runs
TB-500 by prescription. Coming soon.
- 01Coming soon
- 02Single ingredient
- 03Provider reviewed
- 04Free to join the list
The people pictured are models, not patients.
Why TB-500
From a repair protein
Thymosin beta-4 binds actin and helps cells move during tissue repair, in lab and animal research.
One ingredient, pharmacy-made
Ours will be TB-500 acetate on its own, compounded for you by a state-licensed US 503A pharmacy.
First in line
Join the list and we will text and email you the day it is ready to order. Free, no payment now.
How we compare
TB-500, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Understand your treatment
A fragment, not the whole protein.
TB-500 is often confused with thymosin beta-4. It is a seven-amino-acid piece of it, the region that binds actin. HHS's policy names this fragment, as an injection under the skin or into muscle.
A closer look
A fragment, not the whole protein.
Thymosin beta-4
LKKTETQ
Injection
Make a more informed choice
TB-500 vs. thymosin beta-4
Thymosin beta-4 is a 43-amino-acid protein studied in tissue repair. TB-500 is the acetylated LKKTETQ fragment. They are different molecules, and research on one does not automatically apply to the other.
Explore the ingredient research
- Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51.
- HHS. Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances, Appendices A and B. October 2026.
A straightforward path to care
Join the list
Leave your email and mobile number. We tell you the day it is ready to order.
Provider review
The day our pharmacy can fill TB-500 as a single-ingredient prescription, you get a text and an email.
Ships to your door
Order online, do a short intake, and a US-licensed provider decides if TB-500 is right for you.
Ongoing support
A state-licensed US 503A pharmacy makes it for you by name and ships it free in plain packaging.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
About TB-500
TB-500 is the acetylated seven-amino-acid fragment Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ). It copies the actin-binding region of thymosin beta-4, a 43-amino-acid protein studied in tissue repair. It is a different molecule from the full protein. Ours will be TB-500 acetate as the only active ingredient, compounded by a US 503A pharmacy.
- A seven-amino-acid fragment of thymosin beta-4
- TB-500 acetate, the only active ingredient
- Injected under the skin or into muscle, as your provider directs
- Prescribed after a US-licensed provider review
Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (HHS Appendix B, 2026).
Thymosin beta-4
a 43-amino-acid protein found in most cells
Amino acids 17 to 23
its actin-binding region, LKKTETQ
TB-500
an acetylated copy of that seven-amino-acid region
A short fragment of a repair protein, coming as a prescription.
What the research shows
TB-500 research leans on its parent protein, thymosin beta-4. Here is what the record shows.
7
amino acids make up TB-500: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln.
HHS Appendix B, 2026
Actin
is what thymosin beta-4 binds, helping cells move during tissue repair in lab and animal research.
Goldstein et al., Expert Opin Biol Ther 2012
2 routes
HHS's policy covers TB-500 under the skin or into muscle.
HHS 503A peptide policy, 2026
References
- Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51.
- HHS. Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances, Appendices A and B. October 2026.
HealthRX.com or Research-use sites
Two very different ways to get TB-500
| HealthRX.com | Research-use sites | |
|---|---|---|
| Who makes it | A state-licensed US 503A pharmacy, from your prescription | Often overseas labs, sold as powder in a vial |
| Labeled for | You, by name, with your provider's directions | "Research use only. Not for human use." |
| Who checks it fits you | A US-licensed provider reviews your health history | No one |
| What is in it | TB-500 acetate, one ingredient | The seller's own claims |
| Questions later | Message your care team anytime | Seller support, if any |
| Price | Shown up front, full refund if not prescribed | Often less per vial, with no medical review |
What to expect
Here is what happens from joining the list to your first order.
Today
Join the list
Free. No payment and no intake yet.
Launch day
You hear first
We text and email you the moment it is ready to order.
Then
Order and do your intake
Choose a plan, then a short online health intake for a provider to review.
Within about a week
It arrives
If prescribed, the pharmacy ships it in plain packaging, with your directions on the label.
Safety and side effects
TB-500 is compounded by a US-licensed 503A pharmacy and is not FDA approved. FDA has not reviewed it for safety, effectiveness or quality, and human studies are small. A licensed provider reviews your health history and medicines before deciding whether to prescribe it. It is not for use during pregnancy or breastfeeding, or by anyone under 18. Report side effects to your provider, or to FDA MedWatch at 1-800-FDA-1088.
Common
- Redness, swelling or itching where you inject
- A small bruise at the injection site
Less common
- Soreness at the injection site that lasts more than a day
Seek care
- Signs of an allergic reaction: hives, swelling of the face or throat, or trouble breathing
- Signs of infection where you inject: spreading redness, warmth or fever
Human safety data for TB-500 are limited. Tell your provider about every medicine you take before starting. This is not a complete list of side effects.
Frequently asked questions
What does the research show?
Thymosin beta-4, the protein TB-500 comes from, binds actin and helps cells move during tissue repair in lab and animal research (Goldstein et al., 2012). Research on the full protein does not automatically apply to the fragment. Your provider will go through what is and is not known.
What will it cost?
We will show every price on this page before launch, with the online provider visit, the medication if prescribed and shipping included. Joining the list is free.
Who should not take TB-500?
It is not for anyone pregnant, breastfeeding or under 18. Your provider reviews your health history and medicines before deciding.
Other longevity options
Everyday essentials for your routine.
No prescription needed. Dietary supplements for the daily habits around your care, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
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Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.