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RxPrescription Skincare
A retinoid your skin can keep up with.
40,000+ products sold · LegitScript certified
Tretinoin + niacinamide cream · With hyaluronic acid
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$134 billed today, then every month until canceled.
Not prescribed? Full refund.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before anything ships.
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Common questions
LegitScript certifiedCert. 50087439
Evening skincare
The people pictured are models, not patients.
Most retinoid routines fail in the first month when dryness sets in and people stop. Niacinamide and hyaluronic acid are added to support the barrier so you can stay consistent. Compounded by a US-licensed pharmacy.
Tretinoin drives cell turnover, niacinamide 4 percent supports tone and the barrier, and hyaluronic acid draws in moisture. One nightly step instead of three products.
The added niacinamide and hyaluronic acid are meant to soften early dryness, though some flaking is still normal while your skin adjusts.
A US-licensed provider confirms this formula is appropriate for you before it ships. Real pricing, shown up front.
How we compare
Understand your treatment
This blend combines tretinoin, niacinamide 4% and hyaluronic acid in one topical formula. Tretinoin acts through retinoic-acid receptors; niacinamide has a separate research history in skin appearance and barrier biology. Hyaluronic acid is the moisture-focused component. Reading the formula as distinct ingredient roles is more useful than treating it as a generic anti-aging cream. It also helps you compare the blend with tretinoin alone and with the separate version that includes vitamin C.
A closer look
A retinoid with vitamin B3 and moisture-focused support.
Make a more informed choice
This listing includes niacinamide 4% and hyaluronic acid alongside tretinoin. The separate vitamin C blend has tretinoin 0.05%, niacinamide 5% and vitamin C 5%. These are different formulations, so compare the complete ingredient lists.
HealthRX.com verified facts
Tretinoin + Niacinamide Cream starts at $107 per month on 12-month plan; the lowest checkout charge is $134 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified August 26, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
Choose your treatment options and complete secure checkout. Then complete the online health intake.
A licensed physician (MD) reviews your completed intake and prescribes your tretinoin and niacinamide cream if it is appropriate for you.
A US-licensed pharmacy compounds your cream and ships it free in discreet packaging.
Message your care team anytime, and your provider adjusts your plan as your skin builds tolerance.
Most retinoid routines fail in the first month, when dryness sets in and people stop. This one pairs prescription tretinoin with niacinamide to support the skin barrier and hyaluronic acid to hold moisture, so the adjustment period is easier to ride out. Your provider sets the strength. Compounded by a US-licensed pharmacy.
Tretinoin is all-trans retinoic acid; niacinamide supports barrier function and hyaluronic acid draws water into the outer layer. Compounded by a US-licensed pharmacy.
Tretinoin speeds cell turnover
The retinoid activates receptors that push fresh skin cells up and help unclog pores.
Niacinamide supports the barrier
Niacinamide 4 percent helps calm redness and reinforce the barrier that retinoids can dry out.
Hyaluronic acid holds moisture
Hyaluronic acid draws water into the skin to offset the flaking that makes people quit.
Renewal from tretinoin with barrier support from niacinamide and hyaluronic acid, so you can stay consistent.
This exact three-in-one formula has not been studied as a single product. Each active has its own research, so here is what the studies show for tretinoin and niacinamide on their own.
14 of 15
Tretinoin has been studied on its own for photoaging. In a randomized, double-blind, vehicle-controlled trial, 14 of 15 people treating their face with tretinoin improved, versus none on vehicle.
Weiss et al., JAMA 1988
12-week trial
Niacinamide has been studied on its own. In a 12-week, double-blind, split-face trial, topical niacinamide reduced fine lines, hyperpigmented spots, and red blotchiness versus vehicle.
Bissett et al., Dermatol Surg 2005
1x / night
A single cream applied once nightly. No multi-step routine required.
Two ways to run a retinoid
| Tretinoin + niacinamide | Tretinoin alone | |
|---|---|---|
| Barrier support | Niacinamide 4% and hyaluronic acid added | None |
| Early dryness | Buffered to reduce flaking | Often more drying at first |
| Tone support | Niacinamide studied for even tone | Not included |
| Routine | One cream covers three actives | Retinoid plus a separate moisturizer |
| Retinoid strength | Provider-set tretinoin | Provider-set tretinoin |
| Best for | People who quit retinoids over dryness | People who already tolerate tretinoin well |
Gentler than tretinoin alone, but expect some early dryness. Tone and smoothness usually shift by week six to eight. Daily sunscreen keeps it on track.
Weeks 1 to 2
Apply a pea-sized amount a few nights a week after your provider confirms your prescription. The niacinamide and hyaluronic acid are there to ease you in.
Weeks 3 to 5
Some dryness and flaking is still normal. This is where most people quit, so message your care team if you need to adjust your schedule.
Weeks 6 to 8
Skin tone and smoothness usually begin to change in this window as turnover speeds up.
Month 3 and beyond
Texture and clarity continue to build with steady nightly use.
Not prescribed in pregnancy or breastfeeding, and it raises sun sensitivity. Your provider reviews your history first.
This formula contains tretinoin, a retinoid, and must be avoided if you are pregnant, planning to become pregnant, or breastfeeding. Expect an adjustment period of dryness and possible purging in the first several weeks, even though niacinamide and hyaluronic acid are added to soften it. Tretinoin increases sun sensitivity, so apply at night and use sunscreen daily. This is not a complete list of side effects. Tell your provider about every medication and skincare product you use before starting.
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Hydroquinone 8% / Tretinoin / Vitamin C / Niacinamide
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Dapsone 3% / Tretinoin 0.07% / Niacinamide 4%
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Learn MoreNo prescription needed. Dietary supplements to keep alongside your skin care routine, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.
