Tretinoin 0.05%
A defined retinoid concentration in the verified formulation.
- 30 gram containerSupply
- 3 activesIn one formula
- Provider reviewedBefore anything ships
The people pictured are models, not patients.
RxPrescription Skincare
Tretinoin / Niacinamide / Vitamin C
A retinoid blend with vitamin C.
40,000+ products sold · LegitScript certified
Tretinoin 0.05%, niacinamide 5% and vitamin C 5% in one cream. Explore retinoid signaling and the supporting vitamin ingredients before comparing formulas.
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- ✓Medication and supplies
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- Then $150 Every Month
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- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships to your doorIf prescribed, in a plain box
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
How is this different from the existing tretinoin and niacinamide cream?
This formula contains vitamin C 5% as its third ingredient. The existing tretinoin and niacinamide option includes hyaluronic acid instead.
What ingredients and strengths are included?
Tretinoin 0.05%, niacinamide 5% and vitamin C 5%.
Can I subscribe or make a one-time purchase?
Yes. Choose Subscribe & Save or One-time purchase in the plan picker. The price and selected plan are displayed before checkout.
LegitScript certifiedCert. 50087439- US-licensed pharmacyPrepares every prescription
- Independent cliniciansUS-licensed, in your state
- 40,000+Products sold
- All 50 statesFree, discreet shipping
- No insurance requiredOne price, shown up front
Evening skincare
A retinoid blend with vitamin C.
- 01Tretinoin 0.05%
- 02Niacinamide 5%
- 03Vitamin C 5%
The people pictured are models, not patients.
Why Tretinoin / Niacinamide / Vitamin C
Niacinamide 5%
The same vitamin B3 concentration evaluated in a 12-week skin-appearance trial.
Vitamin C 5%
The third ingredient in this blend, replacing the hyaluronic acid found in another option.
One combined formula
Three named ingredients and concentrations, shown together before you choose a plan.
How we compare
Tretinoin / Niacinamide / Vitamin C, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Meet the formula
A retinoid routine with a complete ingredient story.
The three names in this cream represent different ingredient families. Tretinoin supplies the retinoid component, niacinamide supplies a topical form of vitamin B3, and vitamin C supplies an antioxidant ingredient. Together they define a specific blend: tretinoin 0.05%, niacinamide 5% and vitamin C 5%. Understanding each role makes the product more informative than a general “renewal” description and gives you a clear basis for comparing it with tretinoin alone or another combination cream.
01
Retinoid signaling
Tretinoin and retinoic-acid receptors
02
Vitamin B3
Niacinamide and skin-appearance research
03
Vitamin C
Antioxidant and collagen-biology context
Inside the formula
The names on the label, explained.
0.05%
Tretinoin
Tretinoin is retinoic acid, a vitamin A derivative that acts through retinoic-acid receptors. It is the retinoid at the center of this blend. Research on topical tretinoin includes acne and photoaged skin. Its ingredient identity distinguishes this cream from a BHA-based exfoliating product and from a hormone-containing estriol formula.
5%
Niacinamide
Niacinamide is a form of vitamin B3 used in topical skincare. Clinical research has examined measures including visible texture and pigmentation. It supplies a supporting vitamin ingredient alongside tretinoin in this formula. The listed 5% describes its own component, rather than changing the meaning of the tretinoin concentration.
5%
Vitamin C
Vitamin C is known for antioxidant activity and its role in collagen biosynthesis. Studies of topical vitamin C have evaluated particular formulations on photoaged skin. Its inclusion distinguishes this blend from a tretinoin-only product and gives it another ingredient family to consider when reviewing the actives already in a routine.
A closer look / 01
Tretinoin and retinol are related, but distinct.
Both sit within the broader vitamin A skincare conversation. Tretinoin is retinoic acid itself; retinol is a different vitamin A form. That distinction is part of why the ingredient name matters as much as the percentage on a product. A retinol serum and a tretinoin cream are different formulations, rather than the same active at two strengths.
The same principle applies to supporting ingredients. Niacinamide and vitamin C do not become retinoids because they are formulated with tretinoin. Reading the blend ingredient by ingredient makes it easier to recognize the central active and the separate supporting components.
A closer look / 02
One formulated cream differs from three separate products.
This listing brings all three named actives into one cream. Buying separate tretinoin, niacinamide and vitamin C products creates a different routine with separate vehicles and strengths. The combined cream therefore has a practical product identity as well as an ingredient identity: one topical formulation, with its specified active list.
When comparing alternatives, write down the active ingredients already present in your treatment products and serums. That shows whether a blend would share ingredients with the current routine. Comparing the full list is more useful than assuming an additional bottle is needed for every ingredient mentioned on the page.
A closer look / 03
Read texture and tone as separate outcomes.
Visible fine lines, surface roughness and uneven pigmentation are different observations. Tretinoin studies and vitamin-ingredient studies have measured specific aspects of skin rather than one universal renewal score. A vehicle-controlled study, for example, compares an active cream with its base to ask what the active contributes. That distinction helps you read ingredient evidence more clearly.
For your own record, keep lighting consistent and note visible texture separately from color and the feel of hydration. The cream’s application experience is another observation. A clear record can capture all of them without treating one good or bad skin day as a complete assessment.
Make an informed comparison
Compare the actual ingredients and formats.
The central question is which active list you are comparing. This cream contains three named actives. Tretinoin-only and tretinoin-niacinamide products have their own specified formulations, while the estriol blend uses a different central ingredient family.
| Option | Ingredient identity | What distinguishes it |
|---|---|---|
| This blend | Tretinoin 0.05% / niacinamide 5% / vitamin C 5% | Retinoid with two vitamin ingredients |
| Tretinoin | Tretinoin | Focused retinoid formulation |
| Estriol / Vitamin C / Hyaluronic Acid | Estriol / vitamin C / hydrolyzed hyaluronic acid | Estrogen, antioxidant and humectant components |
The useful details
A few questions worth answering.
Do the percentages add up to overall strength?
Each percentage belongs to a different molecule. The tretinoin concentration describes tretinoin; the niacinamide and vitamin C concentrations describe their respective components. Adding them would discard the ingredient information that makes this formulation understandable.
What distinguishes this from a pigment-focused blend?
Hydroquinone and kojic-acid formulas place pigment-focused ingredients at the center. This formula places a retinoid at the center, with niacinamide and vitamin C alongside it. A shared skincare goal or shared niacinamide ingredient can coexist with a different complete formula.
Explore the ingredient research
Follow the sources.
See the available product options.
View optionsA straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A licensed provider reviews your health history and determines whether this treatment is appropriate for you.
Ships to your door
If prescribed, a US-licensed pharmacy prepares and ships your medication.
Ongoing support
Contact the care team with questions about your treatment or order.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
Formula details, research & comparisons
About Tretinoin / Niacinamide / Vitamin C
This formula pairs tretinoin with niacinamide and vitamin C in one topical blend. Tretinoin is the retinoid component, niacinamide is vitamin B3, and vitamin C adds a different third ingredient from the hyaluronic acid in the existing tretinoin and niacinamide cream.
- Tretinoin 0.05%
- Niacinamide 5%
- Vitamin C 5%
Tretinoin
The retinoid component in the topical formula.
Niacinamide
Vitamin B3 is paired with the retinoid.
Vitamin C
Completes this three-ingredient formulation.
What the research shows
Niacinamide and vitamin C have been evaluated in separate skin-appearance trials. The references below cover those studied formulations.
50 participants
A separate study evaluated 5% niacinamide over 12 weeks.
Bissett et al., 2005
6 months
A separate vitamin C cream trial followed photoaged skin over six months.
Humbert et al., 2003
Tretinoin + Niacinamide + Vitamin C or Tretinoin + Niacinamide
Compare the ingredients and format before choosing your plan.
| Tretinoin + Niacinamide + Vitamin C | Tretinoin + Niacinamide | |
|---|---|---|
| Formula | Tretinoin / niacinamide / vitamin C | Tretinoin / niacinamide / hyaluronic acid |
| Format | Topical cream | Topical cream |
| Ordering | Online plan selection | Online plan selection |
What to expect
The steps from choosing your plan to continuing your routine.
Getting started
Choose your plan
Compare the ingredients and the available purchase options.
After checkout
Follow your treatment plan
Use the instructions provided with your prescribed formulation.
Along the way
Keep in touch
Contact the existing care team with questions about your treatment or order.
HealthRX.com verified facts
Tretinoin / Niacinamide / Vitamin C online: price and access
Tretinoin / Niacinamide / Vitamin C starts at $150 per month on monthly plan; the lowest checkout charge is $150 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified October 3, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
Frequently asked questions
Which plan lengths can I choose?
This cream currently has a one-month option.
How do I choose between similar formulations?
Compare the ingredient lists and discuss your skin goals with your care team.
Other prescription skincare options
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Tretinoin + Niacinamide Cream
Tretinoin + Niacinamide 4% + Hyaluronic Acid
From $107/mo
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Hydroquinone 8% Cream
Hydroquinone 8% / Tretinoin / Vitamin C / Niacinamide
From $107/mo
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Dapsone Acne Cream
Dapsone 3% / Tretinoin 0.07% / Niacinamide 4%
From $143/mo
Learn MoreAdd to your daily routine.
No prescription needed. Dietary supplements to keep alongside your skin care routine, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Choose a planNo insurance required
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.