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25 clinically reviewed articles, written and peer-reviewed by the HealthRX.com Medical Team.
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Showing 25 of 25 clinical reviews.
A clinical deep-dive into metformin use after bariatric surgery, covering pharmacokinetics, B12 depletion, RYGB vs sleeve gastrectomy differences, dosing, and when to stop or restart.
Read clinical reviewA comprehensive clinical guide to metformin use in autoimmune conditions, covering immunomodulatory mechanisms, disease-specific considerations, drug interactions, and monitoring protocols backed by primary literature.
Read clinical reviewA clinician-level review of metformin's impact on cognitive function, covering mechanistic data, key trials, dosing considerations, and what current guidelines say about diabetes, aging, and brain health.
Read clinical reviewA clinician-level review of how metformin affects skeletal muscle, which patients face the greatest risk of lean-mass loss, and the evidence-based strategies to preserve muscle while staying on metformin therapy.
Read clinical reviewA physician-reviewed, citation-dense review of how metformin affects sexual function in men and women with type 2 diabetes, PCOS, and prediabetes. Covers testosterone, erectile dysfunction, libido, and clinical management strategies.
Read clinical reviewA clinician-level review of how metformin affects appetite, cravings, and food intake. Covers proposed mechanisms, clinical trial data, practical dosing context, and what patients can realistically expect.
Read clinical reviewA clinician-level review of how metformin affects bone mineral density, fracture risk, osteoblast activity, and osteoporosis outcomes in type 2 diabetes, with primary-literature citations throughout.
Read clinical reviewA clinician-level review of metformin's cancer risk signals, covering proposed mechanisms, key trials, confounding factors, and current guideline positions for patients with type 2 diabetes or prediabetes.
Read clinical reviewA clinician-level review of metformin's long-term cardiovascular effects, from UKPDS 34 through modern meta-analyses. Covers mechanisms, trial data, guideline positions, and practical prescribing context.
Read clinical reviewA physician-reviewed comparison of compounded and branded metformin, covering bioequivalence, cost, formulation differences, safety, and how to choose the right option for type 2 diabetes or prediabetes management.
Read clinical reviewA physician-level breakdown of the metformin evidence base, with each major indication graded by GRADE certainty of evidence, key trial data, and practical clinical guidance.
Read clinical reviewA clinician-reviewed guide to metformin's effects on hair loss, skin pigmentation, acne, and wound healing. Covers B12-mediated hair thinning, androgen-driven skin benefits in PCOS, and practical monitoring thresholds backed by primary literature.
Read clinical reviewA physician-reviewed deep dive into how metformin affects the liver, including NAFLD, lactic acidosis risk, hepatic glucose output, and safety in liver disease. Backed by primary-literature citations throughout.
Read clinical reviewA physician-reviewed, evidence-based look at how metformin affects mental health and mood, covering depression, cognitive function, anxiety, B12 depletion, and clinical management guidance.
Read clinical reviewHow metformin alters mitochondrial function, AMPK signaling, hepatic glucose output, and total energy expenditure. MD/PharmD-level review with primary-literature citations for clinicians and informed patients.
Read clinical reviewA clinical review of metformin microdosing protocols for type 2 diabetes, prediabetes, longevity, and off-label use. Covers dosing thresholds, tolerability data, titration schedules, and what current guidelines do and do not support.
Read clinical reviewWhy metformin stops working, how to identify true non-response vs. Adherence gaps, and the clinical steps to restore glycemic control. MD/PharmD-level guide with primary-literature citations.
Read clinical reviewA physician-reviewed guide to the metformin pre-surgery hold window, covering current ADA and AACE guidelines, contrast-dye rules, procedure-specific timing, and restart protocols with primary-literature citations throughout.
Read clinical reviewStopping metformin can cause blood glucose to rise sharply within days. This guide covers the clinical evidence on rebound hyperglycemia, the mechanisms behind it, who is most at risk, and how to taper or transition safely.
Read clinical reviewWhen and how to safely restart metformin after acute illness, hospitalization, or surgery. Evidence-based guidance covering lactic acidosis risk, renal thresholds, contrast dye rules, and step-by-step restart protocols.
Read clinical reviewHow temperature extremes, seasonal illness, hydration shifts, and activity changes affect metformin dosing, safety, and efficacy across all four seasons. MD/PharmD-level guidance with primary-literature citations.
Read clinical reviewA clinician-level review of how metformin affects sleep architecture, slow-wave sleep, REM duration, and circadian signaling, with primary-literature citations and dosing context.
Read clinical reviewA clinician-reviewed guide to adjusting metformin dosing schedules across time zones, managing GI side effects during travel, and handling iodinated contrast or high-altitude exposure. Includes primary-literature citations and a practical decision framework.
Read clinical reviewA clinician-level review of metformin's effects on the kidney: emerging evidence for renal protection, updated eGFR dosing thresholds, lactic acidosis risk, and the 2023 ADA/KDIGO guidance on safe use in CKD.
Read clinical reviewA week-by-week clinical guide to your first month on metformin, covering GI side effects, blood sugar changes, dosing titration, and when to call your prescriber.
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