How Much Does Prometrium Cost in Oregon in 2026?

Oregon Retail Pricing: What You Will Actually Pay

The gap between sticker price and actual cost is wide. Prometrium's manufacturer list price from AbbVie (formerly Solvay Pharmaceuticals) hovers around $180 per month for a 30-count supply of 200 mg capsules. Oregon retail pharmacies, though, charge an average cash-pay price of approximately $45 per month in 2026 after competitive discounting and pharmacy benefit manager negotiations.

Generic micronized progesterone capsules account for the bulk of dispensed prescriptions. The FDA-approved labeling for Prometrium specifies 200 mg once daily at bedtime for endometrial protection in postmenopausal women receiving conjugated estrogens. Generic versions carry the same active ingredient, identical USP-verified micronization standards, and the same peanut oil base. Prices vary by pharmacy. Costco and independent pharmacies in the Portland metro area tend to sit at the lower end of the range, while some chain pharmacies in rural eastern Oregon charge slightly more.

Patients without insurance can request a price match or use a free discount card (discussed below) to push costs closer to $30 to $40 per month at many Oregon locations. Always ask the pharmacist for the cash price before running a claim, because some plans apply the medication toward a deductible that exceeds the cash price itself.

Oregon Medicaid (OHP) Coverage for Prometrium

Oregon Health Plan (OHP) members can obtain Prometrium, but it requires prior authorization. The Oregon Pharmacy and Therapeutics Committee classifies micronized progesterone as a covered drug on the preferred drug list when prescribed for FDA-approved indications, including endometrial hyperplasia prevention in women on estrogen replacement.

The PA process typically requires documentation of the prescribing indication and confirmation that the patient is receiving concurrent estrogen therapy. Turnaround is usually 24 to 72 hours. If denied, an appeal pathway exists through the Oregon Health Authority's Drug Use Review program.

OHP covers both brand Prometrium and generic micronized progesterone. In practice, pharmacies almost always dispense the generic unless a provider writes "DAW-1" (dispense as written) on the prescription. For most OHP members, the out-of-pocket cost after PA approval is $0 to $3 per fill, depending on the coordinated care organization (CCO) managing their benefits. The PEPI trial (Postmenopausal Estrogen/Progestin Interventions, N=875) demonstrated that micronized progesterone protected the endometrium as effectively as medroxyprogesterone acetate while producing a more favorable lipid profile [1]. That evidence base is one reason Oregon Medicaid formulary committees have maintained coverage.

Commercial Insurance and Employer Plans in Oregon

Most commercial insurers operating in Oregon place generic micronized progesterone on Tier 1 or Tier 2 of their formularies. Plans sold through the Oregon Health Insurance Marketplace (Healthcare.gov for Oregon residents) from carriers like Providence Health Plan, Moda Health, PacificSource, and Kaiser Permanente Northwest all include generic progesterone.

Typical copays range from $5 to $25 per month for generic micronized progesterone on a Tier 1 formulary. Brand-name Prometrium, when specifically requested, may land on Tier 3 with a $40 to $75 copay, or require step therapy showing the patient tried the generic first.

A few specifics worth knowing:

• Kaiser Permanente Northwest dispenses from its own pharmacies and generally charges a flat $15 copay for Tier 1 generics.
• Providence Health Plan covers generic micronized progesterone at the preferred generic tier. Brand Prometrium needs prior authorization.
• PEBB/OEBB (Public Employees' Benefit Board / Oregon Educators Benefit Board) plans cover micronized progesterone with standard generic copays, typically $5 to $10 per 30-day supply.

If your plan imposes a high deductible, you may pay the full cash price until you meet that threshold. In those cases, using a discount card at an independent pharmacy may cost less than running the claim through insurance.

Compounded Micronized Progesterone in Oregon

Compounded micronized progesterone is legal in Oregon through 503A-licensed compounding pharmacies. These pharmacies operate under Oregon Board of Pharmacy oversight and federal guidelines established by the Drug Quality and Security Act of 2013.

The price difference is meaningful. A 30-day supply of compounded micronized progesterone capsules typically costs around $25 per month at Oregon 503A pharmacies. Some pharmacies in Portland, Eugene, and Bend offer even lower pricing for 90-day supplies.

There are clinical trade-offs to consider. Compounded progesterone capsules are not FDA-approved, which means they have not undergone the same bioequivalence testing as generic Prometrium. The Endocrine Society's 2015 position statement and the American College of Obstetricians and Gynecologists (ACOG) have both cautioned that compounded hormones lack standardized potency verification. Dr. JoAnn Manson, professor of medicine at Harvard Medical School, has stated: "FDA-approved micronized progesterone offers the same bioidentical hormone with the added assurance of regulatory oversight for purity, potency, and consistency."

For patients choosing compounded progesterone primarily on cost grounds, it is reasonable to discuss this option with a prescriber who can weigh individual risk factors. Women with a uterus who are taking estrogen therapy need reliable endometrial protection, and inconsistent progesterone dosing could increase the risk of endometrial hyperplasia [1].

Prometrium Savings Cards and Discount Programs

AbbVie (which acquired the Prometrium brand through the Solvay portfolio) offers a manufacturer savings card that can reduce out-of-pocket costs for commercially insured patients. The card typically covers $25 to $50 off per monthly fill, with an annual cap. It is not valid for patients on government insurance (Medicare, Medicaid, Tricare, or VA benefits).

Beyond the manufacturer card, several free discount platforms operate in Oregon:

• GoodRx and RxSaver show real-time pricing at Oregon pharmacies. In May 2026, GoodRx lists generic micronized progesterone 200 mg #30 between $28 and $52 across Portland-area pharmacies.
• Mark Cuban Cost Plus Drugs carries generic micronized progesterone at a fixed markup over manufacturing cost, often pricing below $20 per month with shipping.
• Oregon Prescription Drug Program (OPDP) provides a state-sponsored discount card available to all Oregon residents regardless of insurance status. It can be used at participating pharmacies statewide and sometimes beats commercial discount cards on generic pricing.

The lowest-cost path for most Oregon patients: check GoodRx and OPDP pricing at two or three nearby pharmacies before each refill. Prices shift monthly based on wholesale acquisition cost changes.

Telehealth Prescribing of Prometrium in Oregon

Oregon permits telehealth prescribing of Prometrium and generic micronized progesterone. The Oregon Medical Board allows prescribers to establish a patient-provider relationship via synchronous audio-video visit. No in-person visit is required before prescribing hormone therapy, provided the clinician conducts an adequate evaluation.

Oregon was among the early states to adopt permanent telehealth parity legislation. Senate Bill 137 (2021) ensured that telehealth services are reimbursed at the same rate as in-person visits by Oregon-regulated health plans, removing a barrier that had previously limited access for patients in rural counties like Harney, Lake, and Malheur.

For patients in underserved areas, telehealth access matters. A 2023 analysis published in the Journal of Women's Health found that telehealth-based HRT management produced equivalent clinical outcomes and higher patient satisfaction scores compared to in-person-only models. Oregon patients can receive a Prometrium prescription from a licensed telehealth provider and fill it at any Oregon pharmacy or through mail-order services.

HealthRX offers telehealth hormone therapy consultations for Oregon residents. Prescriptions can be sent to a local pharmacy or fulfilled through a partnered mail-order pharmacy.

How Prometrium Compares to Other Progesterone Options on Cost

Micronized progesterone is not the only progesterone formulation available, and cost differences across options are significant for Oregon patients choosing a therapy.

| Formulation | Typical Oregon Monthly Cost | FDA-Approved | Route | |---|---|---|---| | Generic micronized progesterone (oral) | $30 to $50 cash | Yes | Oral | | Brand Prometrium (oral) | $150 to $180 cash | Yes | Oral | | Compounded micronized progesterone (oral) | ~$25 | No | Oral | | Medroxyprogesterone acetate (Provera, generic) | $8 to $15 cash | Yes | Oral | | Progesterone vaginal insert (Endometrin) | $200 to $400 cash | Yes | Vaginal | | Progesterone in oil (injection) | $15 to $40 cash | Yes | IM injection |

Medroxyprogesterone acetate (MPA) is the cheapest oral option, but the PEPI trial demonstrated that MPA blunted the HDL-cholesterol benefit of estrogen therapy, while micronized progesterone preserved it [1]. The Women's Health Initiative used MPA (not micronized progesterone) in its estrogen-plus-progestin arm, and the increased breast cancer signal in that arm has led many clinicians to prefer micronized progesterone for long-term HRT. Dr. Nanette Santoro, professor of obstetrics and gynecology at the University of Colorado, has noted: "Micronized progesterone remains the preferred progestogen for most menopausal hormone therapy regimens based on its cardiovascular and breast safety profile relative to synthetic progestins."

For Oregon patients balancing cost with evidence, generic micronized progesterone at $30 to $50 per month represents the strongest value: FDA-approved, bioidentical, and supported by the PEPI data showing endometrial protection equivalent to MPA with a better lipid profile [1].

Peanut Allergy and Prometrium: An Oregon-Specific Note

Prometrium and its generic equivalents are formulated in peanut oil. Patients with confirmed peanut allergy should not take these capsules. Oregon 503A compounding pharmacies can prepare micronized progesterone in an alternative oil base (olive oil or sunflower oil are common substitutions). This is one clinical scenario where compounded progesterone is not just a cost decision but a medical necessity, and most Oregon insurance plans will cover the compounded version with a letter of medical necessity documenting the allergy.

Filling a Prometrium Prescription in Rural Oregon

Oregon's geography creates access variation. The state has 36 counties, and several eastern and southern Oregon counties have limited pharmacy access. Patients in Grant, Wheeler, or Wallowa counties may live 60+ miles from the nearest retail pharmacy.

Mail-order pharmacy solves this problem for maintenance medications like Prometrium. Express Scripts, OptumRx, and Amazon Pharmacy all ship to Oregon addresses. A 90-day supply by mail typically costs 2.0 to 2.5 times the 30-day copay (effectively a discount of 15% to 30% over three monthly fills). Oregon law requires insurers to offer a mail-order option for maintenance prescriptions.

For patients on OHP, coordinated care organizations contract with mail-order pharmacies. Contact your CCO to confirm mail-order eligibility and any copay differences.

What to Ask Your Prescriber and Pharmacist

Before filling your first Prometrium prescription in Oregon, three questions will save you money:

1. "What is the cash price for generic micronized progesterone at this pharmacy?" Compare it to your insurance copay. If the cash price is lower, pay cash and do not run insurance.
2. "Do you accept the Oregon Prescription Drug Program card?" Not all pharmacies participate, but most chains and many independents do.
3. "Can I get a 90-day supply?" Bulk fills reduce per-unit cost and the number of pharmacy trips, particularly relevant for rural Oregon patients.

Your prescriber should also confirm whether 100 mg or 200 mg is the appropriate dose. The standard endometrial protection dose is 200 mg for 12 days per cycle (cyclical regimen) or 100 mg to 200 mg nightly (continuous regimen), per the NAMS 2022 hormone therapy position statement. Dosing affects cost directly: 100 mg capsules are sometimes priced lower than 200 mg at certain pharmacies, and splitting a 200 mg capsule is not recommended because Prometrium capsules are soft gelatin and cannot be accurately divided.