How Much Does Prometrium Cost in Wyoming in 2026?

Wyoming Retail Pricing Breakdown

The average cash price for a 30-day supply of Prometrium 200 mg in Wyoming sits near $45, well below the $180 manufacturer list price set by AbbVie (formerly Solvay Pharmaceuticals). This gap exists because most Wyoming pharmacies stock generic micronized progesterone capsules, which account for the majority of dispensed prescriptions nationwide since the brand lost exclusivity.

Prices vary by pharmacy. Large chains in Cheyenne and Casper tend to cluster between $38 and $52 for a 30-count supply of 200 mg capsules. Independent pharmacies in smaller towns like Sheridan or Riverton may price slightly higher due to lower purchasing volume, though the difference rarely exceeds $10 per month. GoodRx and RxSaver coupons can compress this range further, sometimes pulling below $30 at participating locations.

The Postmenopausal Estrogen/Progestin Interventions (PEPI) trial, a landmark JAMA study (N=875), established that oral micronized progesterone protects the endometrium from hyperplasia during estrogen therapy while producing a more favorable lipid profile than medroxyprogesterone acetate 1. That finding drove widespread clinical adoption of Prometrium and its generics. For Wyoming women on hormone replacement therapy (HRT), this means the drug they need is both well-studied and relatively affordable at the pharmacy counter.

A 100 mg capsule, often prescribed for luteal-phase support or lower-dose endometrial protection, costs proportionally less. Expect $30 to $40 for a 30-day cash-pay supply at most Wyoming locations.

Wyoming Medicaid Does Not Cover Prometrium

Wyoming Medicaid does not include Prometrium or generic micronized progesterone on its preferred drug list. This affects a meaningful portion of the state's population: according to the Centers for Medicare & Medicaid Services, approximately 70,000 Wyoming residents were enrolled in Medicaid as of early 2026.

Patients on Wyoming Medicaid who need endometrial protection during estrogen therapy are typically directed toward medroxyprogesterone acetate (Provera), which is covered. The clinical tradeoff matters. The PEPI trial showed that medroxyprogesterone acetate blunted estrogen's beneficial effects on HDL cholesterol, while micronized progesterone preserved them 1. Dr. JoAnn Manson, professor of medicine at Harvard Medical School, has stated: "Micronized progesterone appears to have a more neutral cardiovascular profile than synthetic progestins, which is an important consideration for long-term HRT."

If your clinician believes micronized progesterone is medically necessary, a prior authorization request can be submitted. Success rates for these appeals in Wyoming are not publicly reported, but the process requires documentation showing clinical intolerance or contraindication to the preferred agent. Budget four to six weeks for a decision.

For Medicaid enrollees unable to obtain coverage, compounded micronized progesterone (discussed below) at roughly $25 per month represents the most affordable alternative.

Compounded Micronized Progesterone in Wyoming

Compounded micronized progesterone is available through licensed 503A compounding pharmacies in Wyoming. This is legal under both federal law (the Drug Quality and Security Act of 2013) and Wyoming State Board of Pharmacy regulations, provided the pharmacy holds a valid 503A license and compounds pursuant to a patient-specific prescription.

The typical cost runs around $25 per month for a 200 mg oral capsule, roughly half the average retail cash price for the FDA-approved generic. Some compounding pharmacies offer vaginal capsules or suppositories at comparable pricing.

A few points deserve attention. Compounded products do not undergo FDA review for bioequivalence, potency uniformity, or stability. The FDA's guidance on compounding permits 503A pharmacies to prepare medications for individual patients but prohibits large-scale manufacturing without 503B registration. Wyoming has two to three 503A pharmacies actively compounding progesterone, most based in Cheyenne and Casper. Telehealth providers can legally send prescriptions to these pharmacies.

Before choosing a compounded product, ask the pharmacy for its most recent potency assay and beyond-use dating. The Endocrine Society recommends FDA-approved formulations as first-line, reserving compounding for patients who need a dose, form, or allergen-free formulation not commercially available.

Insurance Coverage for Prometrium in Wyoming

Commercial insurance plans sold in Wyoming, including those on the ACA marketplace, generally cover generic micronized progesterone with a copay ranging from $5 to $30 per month. Brand-name Prometrium often falls on a higher formulary tier, producing copays of $40 to $75 or sometimes requiring step therapy through the generic first.

The three largest insurers operating in Wyoming's individual and small-group markets (Blue Cross Blue Shield of Wyoming, Cigna, and WINHealth) each list generic micronized progesterone on their formularies. Specific tier placement changes annually. Checking your plan's formulary lookup tool or calling the pharmacy benefit number on your insurance card confirms your copay before filling.

Medicare Part D plans in Wyoming typically cover generic micronized progesterone as well. During the coverage gap (the "donut hole"), out-of-pocket costs for generics dropped to 25% of the negotiated price under the Inflation Reduction Act's provisions. For a drug averaging $45 at retail, that translates to roughly $11 during the gap phase.

Employer-sponsored plans, which cover the majority of insured Wyoming residents, almost universally include generic micronized progesterone. If your employer plan excludes it, your prescriber can submit a formulary exception request citing the PEPI trial data and the American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin on HRT, which supports micronized progesterone for endometrial protection.

The AbbVie Savings Card and Other Discount Programs

AbbVie (which acquired Solvay's portfolio) offers a manufacturer savings card for brand-name Prometrium. Commercially insured patients may pay as little as $25 per fill, with the card covering the difference up to a program maximum. The card is accepted at Wyoming pharmacies and can be activated online or through a prescriber's office.

Limitations exist. The savings card does not apply to government-funded insurance (Medicaid, Medicare, Tricare, VA). It typically expires annually and may cap total annual savings at $1,200 to $1,800. For patients whose commercial insurance places brand Prometrium on a specialty tier, the card can still reduce a $75 copay to $25.

Other discount avenues available in Wyoming:

Manufacturer patient assistance programs through AbbVie may cover the full cost for uninsured patients below 200% of the federal poverty level. The application requires income documentation and prescriber attestation.

Pharmacy discount programs such as GoodRx, RxSaver, and SingleCare are widely accepted across Wyoming. These are not insurance. They function as negotiated rate cards. Prices fluctuate weekly, so comparing across platforms before each fill is worthwhile. The lowest available coupon price for generic micronized progesterone 200 mg in Wyoming has dipped below $25 at specific pharmacies in early 2026.

Mark Cuban's Cost Plus Drugs carries generic micronized progesterone at a transparent markup model (cost plus 15% plus a flat pharmacy fee). Shipping to Wyoming addresses is available, though delivery adds two to five business days.

Telehealth Prescribing of Prometrium in Wyoming

Wyoming permits telehealth prescribing of Prometrium and generic micronized progesterone. The Wyoming Medical Practice Act, updated in 2021, allows prescribers to establish a patient-provider relationship via synchronous audio-video consultation without a prior in-person visit.

This matters for a state with 5.8 people per square mile, the lowest population density in the country. Women in rural counties like Sublette, Hot Springs, or Niobrara may live 90 or more miles from the nearest OB-GYN or menopause specialist. Telehealth eliminates that barrier entirely.

HealthRX and other telehealth platforms can evaluate patients, order relevant lab work (progesterone, estradiol, FSH levels), and send prescriptions electronically to any licensed Wyoming pharmacy, including compounding pharmacies. Follow-up visits for dose adjustments also occur virtually.

Wyoming does not impose a specific telehealth parity mandate for commercial insurers beyond the requirements in existing law, but most major plans in the state cover telehealth visits at the same cost-sharing level as in-person visits. Confirm your plan's telehealth benefit before scheduling.

One prescribing nuance: the clinician must hold a Wyoming medical license or a license through the Interstate Medical Licensure Compact, which Wyoming has joined. This expands the pool of available prescribers beyond those physically located in the state.

Prometrium Dosing and What You Are Paying For

Understanding what you are purchasing helps contextualize cost. The FDA-approved labeling for Prometrium specifies two indications:

Secondary amenorrhea: 400 mg daily for 10 days.

Endometrial protection during estrogen therapy: 200 mg daily at bedtime for 12 consecutive days per 28-day cycle (cyclical dosing) or 100 mg daily continuously.

The capsule contains micronized progesterone suspended in peanut oil. Patients with peanut allergies should use a compounded version in a different vehicle (olive oil or sunflower oil bases are common at 503A pharmacies) or consider vaginal progesterone formulations.

Bedtime dosing is standard because oral micronized progesterone produces a metabolite, allopregnanolone, that causes drowsiness. This side effect actually functions as a benefit for the many menopausal women who report sleep disruption. The REPLENISH trial (N=1,835) confirmed that the combination of estradiol with micronized progesterone improved vasomotor symptoms and sleep quality while maintaining endometrial safety over 12 months 2.

Cost per day at the average Wyoming cash price: $1.50 for the 200 mg capsule. At the compounded price: roughly $0.83 per day. Both figures place micronized progesterone among the least expensive components of a typical HRT regimen, where estradiol patches or gels often represent the larger cost driver.

How to Minimize Your Prometrium Costs in Wyoming

A practical decision tree for Wyoming residents:

First, check whether your insurance covers generic micronized progesterone. If it does, your copay is likely $5 to $30. Fill at a preferred pharmacy to stay in the lowest cost-sharing tier.

If uninsured, compare cash prices across at least three pharmacies using GoodRx or RxSaver. Target pharmacies in Cheyenne or Casper, where competition tends to compress prices.

If Medicaid-enrolled, request a prior authorization through your provider. While approval is uncertain, it costs nothing to try. Simultaneously, obtain a cash-pay quote from a local 503A compounding pharmacy as a backup.

If allergic to peanut oil, request compounded micronized progesterone in an alternative base. This is one scenario where the Endocrine Society acknowledges compounding as a first-line option rather than a fallback 3.

If cost remains prohibitive after exploring all options, AbbVie's patient assistance program is the final safety net. Eligibility is income-based, and approval typically takes two to three weeks.

The 2024 ACOG Committee Opinion on hormone therapy access 4 emphasizes that "cost should not be a barrier to evidence-based hormone therapy," recommending that clinicians actively assist patients in navigating formulary restrictions and discount programs.