24 source-based articles maintained by the HealthRX.com Editorial Team.
Showing 24 of 24 clinical reviews.
A clinical deep-dive into sirolimus pharmacokinetics, wound healing risks, mTOR-mediated metabolic effects, and dosing considerations specific to post-bariatric surgery patients.
A clinical deep-dive into how rapamycin (sirolimus) affects sleep architecture, circadian biology, mTOR signaling in the brain, and what the PEARL trial and related primary literature reveal for patients and prescribers.
A clinician-level review of how rapamycin (sirolimus) affects appetite, hunger signaling, and food cravings, covering transplant doses, low-dose longevity protocols, mTOR biology, and the PEARL trial data.
A physician-reviewed, evidence-based guide to how sirolimus affects autoimmune disease, mechanisms, clinical evidence, dosing considerations, and risks, for clinicians and informed patients.
A physician-reviewed, primary-literature analysis of how rapamycin (sirolimus) affects bone mineral density, osteoblast and osteoclast signaling, fracture risk, and clinical management strategies for transplant and longevity patients.
A physician-level review of the cancer risk data for rapamycin (sirolimus), covering transplant cohorts, mTOR biology, animal data, and what the PEARL trial tells us about off-label longevity use.
A physician-level review of rapamycin (sirolimus) cardiovascular effects over time, covering atherosclerosis, dyslipidemia, hypertension, cardiac aging, and emerging longevity trial data including PEARL 2024.
A physician-reviewed deep dive into how rapamycin (sirolimus) affects cognition in humans and animals, covering mTOR biology, clinical trial data including PEARL (2024), dosing, and safety considerations for off-label longevity use.
A physician-reviewed comparison of compounded sirolimus versus branded Rapamune, covering bioavailability, regulatory status, dosing for off-label longevity use, and what the PEARL trial data show.
A comprehensive clinical review of sirolimus-related dermatologic effects, including acneiform eruptions, hair loss, impaired wound healing, and emerging longevity-dose data, with primary-literature citations throughout.
A physician-reviewed deep dive into how rapamycin (sirolimus) affects liver function, including hepatotoxicity risk, transaminase changes, lipid effects, and monitoring protocols backed by primary literature.
A clinician-level review of how rapamycin (sirolimus) affects mood, cognition, anxiety, and depression, covering mTOR neuroscience, PEARL trial data, and practical prescribing guidance.
A clinical deep-dive into how rapamycin (sirolimus) alters mTOR signaling, mitochondrial function, glucose metabolism, and energy expenditure, with primary-literature citations for physicians and informed patients.
A clinician-level review of rapamycin microdosing protocols for longevity, covering PEARL and other primary trials, dosing regimens, pharmacology, safety data, and what board-certified physicians consider before prescribing off-label sirolimus.
Board-reviewed clinical guide to rapamycin (sirolimus) muscle preservation strategies, covering mTORC1/mTORC2 biology, optimal dosing schedules, resistance training protocols, and nutritional co-interventions backed by primary literature.
Why your rapamycin dose has stopped working and what to do about it: a clinician-level guide to sirolimus plateau, non-response, biomarker drift, and protocol adjustments backed by primary literature.
A physician-level guide to the sirolimus pre-surgery hold window: how long to stop rapamycin before an operation, why wound healing and immune suppression demand a specific washout period, and how to restart safely after surgery.
A physician-level review of what happens when you stop rapamycin (sirolimus): mTOR rebound kinetics, immune reconstitution, clinical data from transplant and longevity contexts, and evidence-based tapering strategies.
A clinician-level guide to adjusting sirolimus dosing, lab monitoring, and infection precautions by season, with primary-literature citations and a practical seasonal framework.
A physician-reviewed deep dive into how rapamycin (sirolimus) affects sexual function in men and women, covering mTOR biology, clinical trial data, dose-dependent effects, and practical management strategies.
MD/PharmD-level guidance on dosing sirolimus across time zones, managing refrigeration, avoiding grapefruit and CYP3A4 interactions on the road, and what the PEARL trial data means for longevity travelers.
A week-by-week clinical guide to the first month on rapamycin (sirolimus) for longevity use, covering pharmacokinetics, expected effects, common side effects, dosing schedules, and monitoring protocols backed by primary literature.
A physician-reviewed deep dive into sirolimus and kidney health: when mTOR inhibition protects the kidney, when it harms it, and what the latest trials including PEARL 2024 say about safe dosing.
A physician-level guide to safely restarting sirolimus after acute illness, covering hold durations, immune recovery markers, dose re-escalation protocols, and the latest evidence from PEARL (2024) and transplant guidelines.