Topic Hub
25 clinically reviewed articles, written and peer-reviewed by the HealthRX.com Medical Team.
Explore
Showing 25 of 25 clinical reviews.
A physician-reviewed comparison of compounded sildenafil versus branded Viagra, covering pharmacokinetics, FDA oversight, cost, efficacy data, and how to choose the right formulation for erectile dysfunction treatment.
Read clinical reviewWhen is it safe to restart sildenafil after a heart attack, stroke, surgery, or serious infection? Board-certified physicians explain the evidence, timing, and dose adjustments.
Read clinical reviewA physician-reviewed deep dive into sildenafil's effects on skeletal muscle, exercise capacity, and emerging preservation strategies. Covers PDE5 inhibition, blood flow, mitochondrial signaling, clinical trials, and practical dosing context.
Read clinical reviewA physician-reviewed deep dive into sildenafil's effects on renal hemodynamics, diabetic nephropathy, AKI risk, and drug interactions, with primary-literature citations throughout.
Read clinical reviewA physician-reviewed, GRADE-graded breakdown of sildenafil's clinical evidence for erectile dysfunction, covering landmark trials, effect sizes, guideline recommendations, and practical dosing.
Read clinical reviewA clinical, week-by-week guide to sildenafil's onset, dose titration, side effects, and what changes you should notice in your first 30 days on Viagra, reviewed by board-certified physicians.
Read clinical reviewA clinician-reviewed look at whether sildenafil (Viagra) affects appetite, hunger, or food cravings, covering the pharmacology, trial data, patient reports, and what to do if you notice changes.
Read clinical reviewSildenafil (Viagra) pharmacokinetics change significantly after Roux-en-Y gastric bypass and sleeve gastrectomy. Learn how altered absorption, faster Cmax, and drug, drug interactions affect dosing, safety, and clinical outcomes after weight-loss surgery.
Read clinical reviewA clinician-level review of sildenafil (Viagra) use in autoimmune and inflammatory conditions, covering pharmacology, drug interactions, disease-specific guidance, and safety data from primary literature.
Read clinical reviewA physician-reviewed deep dive into sildenafil's effects on bone mineral density, osteoblast signaling via PDE5 inhibition, and what the clinical evidence means for patients on long-term Viagra therapy.
Read clinical reviewA physician-reviewed deep dive into sildenafil's effects on cognition, cerebral blood flow, dementia risk, and brain health. Covers PDE5 inhibition mechanisms, clinical trial data, and practical prescribing considerations.
Read clinical reviewA physician-reviewed analysis of every major epidemiological signal linking sildenafil (Viagra) to cancer risk, including melanoma, prostate cancer, and the proposed PDE5 mechanism. Includes trial data, FDA communications, and a clinical decision framework.
Read clinical reviewA clinical deep-dive into sildenafil's long-term cardiovascular effects, covering PDE5 inhibitor mechanisms, mortality data, drug interactions, and who should avoid use. Reviewed by the HealthRX medical team.
Read clinical reviewA clinical deep-dive into the documented hair and skin effects of sildenafil (Viagra), including flushing, rashes, alopecia signals, and what the primary literature actually says.
Read clinical reviewA clinician-level review of how sildenafil (Viagra) is metabolized by the liver, what hepatic impairment means for dosing, and which lab changes to monitor.
Read clinical reviewA physician-reviewed deep dive into sildenafil pharmacokinetics, PDE5 inhibition, thermogenic signaling, and what current evidence says about Viagra and metabolic rate in humans.
Read clinical reviewA clinical review of sildenafil microdosing protocols, including daily low-dose regimens, pharmacokinetic rationale, and evidence from key trials. Reviewed by board-certified physicians.
Read clinical reviewSildenafil stopped working or never worked well? This MD-level guide covers every evidence-based reason for Viagra plateau and non-response, with specific doses, trials, and a step-by-step troubleshooting protocol.
Read clinical reviewA physician-reviewed guide to the sildenafil pre-surgery hold window: why anesthesiologists require it, exactly how long to stop Viagra before an operation, and what happens if the drug is still on board during general or neuraxial anesthesia.
Read clinical reviewDoes stopping sildenafil cause rebound ED, withdrawal, or worsening erectile function? Board-reviewed clinical breakdown of the evidence, mechanisms, and what to do next.
Read clinical reviewA physician-reviewed guide to how temperature, altitude, cardiovascular demand, and seasonal activity patterns affect sildenafil (Viagra) dosing, safety, and efficacy throughout the year.
Read clinical reviewA physician-reviewed, evidence-based breakdown of how sildenafil (Viagra) affects sexual function, covering mechanism, efficacy data from landmark trials, dosing, safety, and who responds best.
Read clinical reviewA clinician-level review of how sildenafil (Viagra) affects REM sleep, slow-wave sleep, nocturnal penile tumescence, and overnight oxygen saturation, with primary-literature citations and dosing guidance.
Read clinical reviewHow to time sildenafil (Viagra) doses when crossing time zones, managing jet lag, altitude, and travel-related factors that affect PDE5 inhibitor pharmacokinetics. Physician-reviewed protocols with primary-source citations.
Read clinical reviewA clinician-level review of how sildenafil (Viagra) affects mood, anxiety, depression, and psychological well-being in men with erectile dysfunction, with primary-literature citations throughout.
Read clinical review