Foundation · No. 01

Compounded Semaglutide

a once-weekly GLP-1 receptor agonist

0.25 MG → 2.4 MG · 4-week vial supply

From

$99/mo

≈ $3.30 / day

Brand-name Wegovy cash

$1,349

$45 / day

Start my free visit→Common questions

A modern medical injector pen, Compounded Semaglutide

Fig. 01 · Compounded SemaglutideLOT 50087439

Semaglutide is the first GLP-1 weight-management compound to enter wide clinical use. It is the active molecule in branded Wegovy® and Ozempic®. The HealthRX.com preparation is compounded by a licensed pharmacy under Section 503A on a valid, patient-specific prescription.

Mechanism · 02

How it works in the body

Semaglutide is a long-acting synthetic analog of human GLP-1, the gut hormone released after a meal. By binding to the GLP-1 receptor, it slows gastric emptying, amplifies the body's satiety signaling in the hypothalamus, and improves glucose-dependent insulin secretion. The result is reduced appetite, quieter food noise, and gradual sustained weight loss.

Titration · 03

The dose ladder.

Week	Dose	Note
Weeks 01–04	0.25 mg / week	Initiation. Lowest dose, designed to acclimate the gut.
Weeks 05–08	0.5 mg / week	First dose escalation. Most appetite changes start here.
Weeks 09–12	1.0 mg / week	Provider check-in. Re-evaluate tolerance and response.
Weeks 13–16	1.7 mg / week	Therapeutic dose for many patients.
Weeks 17+	2.4 mg / week	Maintenance dose, only if tolerated and clinically appropriate.

Risks · 05

Side effects, honestly.

Common

· Nausea (most common during titration)
· Diarrhea or constipation
· Decreased appetite (the therapeutic effect)
· Mild headache, fatigue
· Burping, indigestion

Serious

· Pancreatitis (rare)
· Gallbladder disease
· Hypoglycemia (especially with other diabetes medications)
· Possible thyroid C-cell tumors (animal studies in rats; relevance to humans unknown)

Fit · 06

Who it's for. Who it isn't.

Suitable for

· Adults with BMI ≥ 30, or BMI ≥ 27 with a weight-related condition
· Patients new to GLP-1 therapy
· Patients seeking the most studied compound in the category

Not suitable for

· Personal or family history of medullary thyroid carcinoma
· Multiple Endocrine Neoplasia syndrome type 2 (MEN-2)
· History of severe pancreatitis
· Pregnant or breastfeeding
· Severe gastrointestinal disease

Common questions · 07

Questions, answered.

How much does compounded semaglutide cost at HealthRX.com?

Compounded semaglutide plans start at $99/mo with the annual option. The price you see at checkout is the price billed. No insurance required.

Is compounded semaglutide the same as Wegovy or Ozempic?

Semaglutide is the active molecule in branded Wegovy and Ozempic. The HealthRX.com preparation is compounded by a licensed 503A pharmacy on a valid, patient-specific prescription. It is not the branded product.

How much weight can I expect to lose on semaglutide?

In the STEP-1 trial, adults lost an average of 14.9% of body weight at 68 weeks, and 86% lost at least 5% of body weight. Individual results vary and depend on dose, tolerance, and lifestyle.

How is semaglutide dosed?

Semaglutide is a once-weekly injection titrated from 0.25 mg up to a maintenance dose (up to 2.4 mg) over several months, escalated only as tolerated and clinically appropriate under provider supervision.

Who should not take semaglutide?

Semaglutide is not appropriate for people with a personal or family history of medullary thyroid carcinoma or MEN-2, a history of severe pancreatitis, or during pregnancy or breastfeeding. A licensed clinician reviews your history before prescribing.