Sexual Health
Tadalafil
Up to 36 hours in your system, at either strength.
Tadalafil's 17.5-hour half-life gives this dose a window of activity that can run up to 36 hours, in 10mg or 20mg. A board-certified physician confirms the strength that's clinically appropriate for you before it ships.
Strength
Doses per month
Your provider confirms or adjusts your strength during your free online visit.
Purchase type
Save 10% today and on every refill. Auto-renews at your selected cadence, pause or cancel anytime.
Cadence
Strength set by your provider. They confirm the right strength and dose for you during your online visit.
Only available if prescribed after an online consultation with a licensed provider.
What's included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
One dose, up to 36 hours
Tadalafil has a long half-life, so a single as-needed dose can keep you covered for up to a day and a half. Intimacy does not have to be timed to the minute.
Works with or without food
Unlike sildenafil, tadalafil absorption is not affected by meals, so a heavy dinner will not change how it works.
The active ingredient in Cialis
Tadalafil is the same active ingredient found in branded Cialis, compounded by a US-licensed pharmacy at 10 mg or 20 mg.
A provider reviews you first
A US-licensed provider checks your health history and heart risks before prescribing. Real pricing, shown up front.
From quiz to your door
Tadalafil works through the same PDE5 mechanism as sildenafil, but its pharmacokinetics differ in one important way: a half-life of roughly 17.5 hours, compared with a few hours for sildenafil, which is what stretches its window of activity out to as long as 36 hours at either strength. Like every PDE5 inhibitor, tadalafil requires sexual arousal to work, so the extended window changes how long the option stays available in your system, not whether stimulation is still necessary. 20mg delivers more active drug than 10mg for people who need a stronger response, and clinical evidence shows no benefit from exceeding 20mg on an as-needed basis.
Answer a few health questions
Complete a short online visit about your health, heart history, and the medications you take.
A provider reviews
A US-licensed provider reviews your history and prescribes tadalafil if it is appropriate for you.
The pharmacy ships free
A US-licensed pharmacy compounds your dose and ships it free in discreet packaging.
Adjust with follow-ups
Message your care team anytime, and your provider can move you between 10 mg and 20 mg based on how you respond.
About Tadalafil
- Roughly 36 hours of coverage from one dose, well beyond sildenafil's four-to-six-hour range
- Absorption unaffected by meal timing, unlike sildenafil
- 20mg available in your file if 10mg doesn't produce enough of a response, with no benefit past it
- Approved by the FDA in 2003, extending the PDE5 inhibitor class beyond sildenafil alone
- Scheduling flexibility for people who'd rather not plan around one fixed hour
What the studies show
Tadalafil has been evaluated in randomized controlled trials for erectile dysfunction, including its long duration of action. Here is what that research found.
- Brock GB, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002;168(4 Pt 1):1332-1336.
- Porst H, et al. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Urology. 2003;62(1):121-125.
Two different approaches
Two ways to take tadalafil
| Tadalafil as needed | Tadalafil daily | |
|---|---|---|
| How you take it | A dose before intimacy | One low dose every day |
| Spontaneity | Up to a 36 hour window | Always ready, no timing |
| Strength | 10 mg or 20 mg | 2.5 mg or 5 mg |
| If sex is infrequent | ✓Only take it when you want it | Taken every day regardless |
| If sex is frequent | Redose to stay covered | Steady coverage without planning |
| Active ingredient | Same as branded Cialis | Same as branded Cialis for daily use |
Your first months
Onset typically falls between thirty and sixty minutes, with concentration peaking around the two-hour mark, later than sildenafil's roughly one-hour peak, the same timeline at 10mg or 20mg. Unlike sildenafil, absorption isn't meaningfully affected by food, so timing doesn't depend on when you last ate. From there, the effect can persist for up to 36 hours, which is why some clinicians describe it as extended-coverage dosing rather than single-event dosing. 20mg is generally reserved for people whose response to 10mg wasn't strong enough, and the documented side-effect profile can run somewhat more pronounced at that dose: nasal congestion, muscle or back aches, indigestion, flushing, and headache.
It takes effect
Take one tablet ahead of intimacy, and food does not need to be timed around it.
Your window opens
Tadalafil stays effective across a long window, so intimacy does not have to be scheduled tightly.
Still covered
A single dose can remain effective up to a day and a half later, with arousal still required.
Dial in your dose
Your provider can adjust between 10 mg and 20 mg based on how you respond.
What members say
“The long window is the whole point for me. One dose on Friday and I am not watching the clock all weekend.”
“I like that dinner does not matter. Take it, forget about it, and it is there when things happen.”
“My provider reviewed my meds and blood pressure first, then prescribed. Clear pricing, no games.”
Ratings and member reviews shown here are illustrative composites built from anonymized intake-to-outcome data; identifying details have been altered. Individual results vary. Compounded medications are not FDA-approved.
What to know about side effects
Nitrates and alpha-blockers are both absolute contraindications with tadalafil at either strength; combining either can send your blood pressure to unsafe lows. Your provider also checks for cardiovascular disease, uncontrolled blood pressure, and liver or kidney impairment before prescribing, since reduced organ function changes how tadalafil clears from your body. Side effects can run somewhat more pronounced at 20mg than at 10mg. If your provider decides tadalafil isn't clinically appropriate for you, you won't be charged for the medication.
Most common
- Headache
- Flushing
- Indigestion
- Back pain or muscle aches
Less common, talk to your provider
- Nasal congestion
- Changes in vision
- Dizziness
Rare but serious, seek care
- An erection lasting more than four hours, called priapism, which needs emergency care
- Sudden loss of vision or hearing, or chest pain, seek care right away
Frequently asked questions
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.