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- US-licensed pharmacy
- Ships in 3 to 5 days
Common questions
Tretinoin + Niacinamide Cream
A retinoid your skin can keep up with.
Tretinoin + niacinamide cream · With hyaluronic acid
- Tretinoin paired with niacinamide
- Buffered for fewer dropouts
- One nightly cream
- Provider-reviewed
Find the plan that fits you.
Answer three quick questions to match your priorities and budget. Get your recommendation and free skin treatment guide by text. No card to start.
Purchase type
Save 10% today and on every refill. Auto-renews at your selected cadence, pause or cancel anytime.
Cadence
Strength set by your provider. They confirm the right strength and dose after reviewing your required post-purchase intake.
Payment does not guarantee a prescription. Complete the required pharmacist intake after purchase.
What's included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before anything ships.
A retinoid your skin can keep up with
Most retinoid routines fail in the first month when dryness sets in and people stop. Niacinamide and hyaluronic acid are added to support the barrier so you can stay consistent. Compounded by a US-licensed pharmacy.
Three actives, one cream
Tretinoin drives cell turnover, niacinamide 4 percent supports tone and the barrier, and hyaluronic acid draws in moisture. One nightly step instead of three products.
Gentler than tretinoin alone
The added niacinamide and hyaluronic acid are meant to soften early dryness, though some flaking is still normal while your skin adjusts.
A provider reviews your skin
A US-licensed provider confirms this formula is appropriate for you before it ships. Real pricing, shown up front.
About Tretinoin + Niacinamide Cream
Most retinoid routines fail in the first month, when dryness sets in and people stop. This one pairs prescription tretinoin with niacinamide to support the skin barrier and hyaluronic acid to hold moisture, so the adjustment period is easier to ride out. Your provider sets the strength. Compounded by a US-licensed pharmacy.
- Tretinoin paired with barrier support
- Built to be tolerable enough to finish
- Niacinamide for redness and pore appearance
- Real pricing up front, discreet shipping
Tretinoin is all-trans retinoic acid; niacinamide supports barrier function and hyaluronic acid draws water into the outer layer. Compounded by a US-licensed pharmacy.
Tretinoin speeds cell turnover
The retinoid activates receptors that push fresh skin cells up and help unclog pores.
Niacinamide supports the barrier
Niacinamide 4 percent helps calm redness and reinforce the barrier that retinoids can dry out.
Hyaluronic acid holds moisture
Hyaluronic acid draws water into the skin to offset the flaking that makes people quit.
Renewal from tretinoin with barrier support from niacinamide and hyaluronic acid, so you can stay consistent.
How to get it
Today
Take the quiz
Answer a few questions about your skin, your goals, and your health history.
Next
A provider reviews
A US-licensed provider reviews your intake and prescribes your tretinoin and niacinamide cream if it is appropriate for you.
3 to 5 days
The pharmacy ships
A US-licensed pharmacy compounds your cream and ships it free in discreet packaging.
Ongoing
Stay on track
Message your care team anytime, and your provider adjusts your plan as your skin builds tolerance.
What the research shows
This exact three-in-one formula has not been studied as a single product. Each active has its own research, so here is what the studies show for tretinoin and niacinamide on their own.
14 of 15
Tretinoin has been studied on its own for photoaging. In a randomized, double-blind, vehicle-controlled trial, 14 of 15 people treating their face with tretinoin improved, versus none on vehicle.
Weiss et al., JAMA 1988
12-week trial
Niacinamide has been studied on its own. In a 12-week, double-blind, split-face trial, topical niacinamide reduced fine lines, hyperpigmented spots, and red blotchiness versus vehicle.
Bissett et al., Dermatol Surg 2005
1x / night
A single cream applied once nightly. No multi-step routine required.
Tretinoin + niacinamide or Tretinoin alone
Two ways to run a retinoid
| Tretinoin + niacinamide | Tretinoin alone | |
|---|---|---|
| Barrier support | Niacinamide 4% and hyaluronic acid added | None |
| Early dryness | Buffered to reduce flaking | Often more drying at first |
| Tone support | Niacinamide studied for even tone | Not included |
| Routine | One cream covers three actives | Retinoid plus a separate moisturizer |
| Retinoid strength | Provider-set tretinoin | Provider-set tretinoin |
| Best for | People who quit retinoids over dryness | People who already tolerate tretinoin well |
What to expect
Gentler than tretinoin alone, but expect some early dryness. Tone and smoothness usually shift by week six to eight. Daily sunscreen keeps it on track.
- Weeks 1 to 2
Start your cream
Apply a pea-sized amount a few nights a week after your provider confirms your prescription. The niacinamide and hyaluronic acid are there to ease you in.
- Weeks 3 to 5
Adjust and stay consistent
Some dryness and flaking is still normal. This is where most people quit, so message your care team if you need to adjust your schedule.
- Weeks 6 to 8
Tone and smoothness shift
Skin tone and smoothness usually begin to change in this window as turnover speeds up.
- Month 3 and beyond
Results build
Texture and clarity continue to build with steady nightly use.
Safety and side effects
Not prescribed in pregnancy or breastfeeding, and it raises sun sensitivity. Your provider reviews your history first.
Common
- Dryness and flaking, usually milder than tretinoin alone
- Mild redness or irritation
- Increased sun sensitivity
- Temporary stinging on application
Less common
- A temporary purge of breakouts as skin adjusts
- Peeling around the mouth and eyes
- Temporary darkening or lightening of treated spots
Seek care
- Severe blistering, swelling, or crusting of the skin
- Signs of an allergic reaction such as rash or swelling of the lips or throat
This formula contains tretinoin, a retinoid, and must be avoided if you are pregnant, planning to become pregnant, or breastfeeding. Expect an adjustment period of dryness and possible purging in the first several weeks, even though niacinamide and hyaluronic acid are added to soften it. Tretinoin increases sun sensitivity, so apply at night and use sunscreen daily. This is not a complete list of side effects. Tell your provider about every medication and skincare product you use before starting.
Frequently asked questions
Other prescription skincare options
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.