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HealthRX.com · Printable symptom log

Quitting nicotine while starting Wegovy: weekly log

Note your quit date, what you smoked or vaped and the aid you chose, then log nicotine use, patch step or varenicline dose, weight, resting heart rate and nausea each week as Wegovy steps up. The patch schedule and the label warning signs are printed alongside.

Companion to “Wegovy Nicotine Interaction Profile: What Clinicians and Patients Need to Know” · healthrx.com/interactions-v2-wegovy/nicotine-interaction · Facts checked 2026-10-18

Where you are starting

Quit date
Cigarettes a day before quitting, or vaping and other nicotine use
Quit aid chosenpatch, gum, lozenge, varenicline, bupropion, none
Resting heart rate and blood pressure before Wegovy
Weight on the quit date

Nicotine patch steps on the NicoDerm CQ label[1]

For more than 10 cigarettes a day. At 10 or fewer a day the label skips Step 1: 14 mg for 6 weeks, then 7 mg for 2 weeks, then stop.

StepPatchWeeks
Step 121 mg a dayWeeks 1-6
Step 214 mg a dayWeeks 7-8
Step 37 mg a dayWeeks 9-10

Week-by-week check

Write the Wegovy dose for each week so nausea or a heart-rate change can be matched to a dose step or to the quit aid.

WeekWegovy doseCigarettes or nicotine usedPatch step or varenicline doseWeightResting heart rateNausea: none, mild, bad

Numbers from the sources

  • People who quit without medicine gained on average 4.67 kg by 12 months, most of it in the first three months.[2]
  • Varenicline 1 mg twice daily: nausea in 30% versus 10% on placebo. If nausea is intolerable, the label says a dose reduction should be considered.[3]
  • Wegovy raised resting heart rate by 1 to 4 beats per minute on average compared with placebo; a sustained rise means stopping Wegovy.[4]

Stop and call your healthcare provider for

  • New or worse mood or behavior changes on varenicline, such as agitation, depressed mood or suicidal thoughts.[3]
  • Irregular heartbeat or palpitations, or signs of too much nicotine (nausea, vomiting, dizziness, weakness, rapid heartbeat) while using the patch.[1]
  • A resting heart rate that stays higher than usual on Wegovy.[4]

To ask at the 4-week and 12-week visits

  1. Which quit aid adds the least nausea while my Wegovy dose is still going up?
  2. Should I quit first and start Wegovy later, or start both now?
  3. Is my resting heart rate change from Wegovy, from nicotine, or from both?
  4. How will we confirm I have quit, and when?
  5. If I slip back to smoking, should anything about my Wegovy plan change?
Sources for the facts on this sheet
  1. Haleon US Holdings, via DailyMed. NicoDerm CQ (nicotine transdermal system) stop smoking aid: Drug Facts. Effective 2025-07-14. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=93b2d1b9-83c1-40b5-b6af-90c38c8d6cef
  2. Aubin HJ, Farley A, Lycett D, Lahmek P, Aveyard P. Weight gain in smokers after quitting cigarettes: meta-analysis. BMJ 2012. PMID 22782848. https://pubmed.ncbi.nlm.nih.gov/22782848/
  3. Pfizer Laboratories, via DailyMed. Chantix (varenicline) tablets, for oral use: prescribing information and Medication Guide. Effective 2026-01-23. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f0ff4f27-5185-4881-a749-c6b7a0ca5696
  4. Novo Nordisk, via DailyMed. Wegovy (semaglutide) injection, for subcutaneous use, and Wegovy (semaglutide) tablets, for oral use: prescribing information and Medication Guide. Effective 2026-06-18. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ee06186f-2aa3-4990-a760-757579d8f77b

This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.