HealthRX.com · Printable symptom log
Energy, mood, libido and relationship change record for a MOTS-c claim
A personal story can raise a question but cannot answer it. Record the one outcome you hoped would change next to everything else that changed in the same weeks, then take the sheet to a clinician who can look at the underlying problem directly.
The outcome you hoped would change
Main outcomeenergy, fatigue, mood, sexual interest or the relationship itself; pick one
How you would know it changedsomething you can rate or count the same way each week
When the problem began, and what else started around then
The product in question
Name and form printed on the label
Seller or pharmacy
Lot number and stated amount per vial
Any independent identity or purity test you were shown
Weekly record
Rate each item the same way every week, and write down changes even when they seem unrelated.
| Week of | Energy | Mood | Sexual interest | Sleep | Alcohol, stress or training changes | Medicine or supplement changes | Relationship events |
|---|---|---|---|---|---|---|---|
Other explanations to rule out before crediting the product
- Training, sleep, diet, alcohol use or stress changed during the same weeks
- Expecting a change, or paying closer attention, altered how symptoms were noticed
- Another medicine or supplement was started, stopped or changed
- The product's identity, concentration or impurities were never independently checked
- A relationship event or ordinary week-to-week variation fell in the same period
What the evidence covers
- FDA's July 2026 review found no clinical studies or human exposure data for MOTS-c by any route.[1]
- The uses proposed to FDA for MOTS-c were insulin resistance, obesity, osteoporosis, vascular calcification, muscle/fat metabolism and longevity.[1]
- Better physical performance after MOTS-c treatment was reported in mice, not in people.[2]
- The registered MOTS-c trial measures insulin sensitivity, glucose and adverse events, not mood, libido or relationships, and has posted no results.[3]
Questions for a clinician about the problem itself
- What could be behind my low energy or fatigue, and what would you look at first?
- Could a medicine I already take be affecting my mood or sexual interest?
- Could my sleep explain how I feel during the day?
- Would it help to see someone who treats mood or relationship concerns directly?
- What should I track before the next visit so we can tell whether anything is changing?
Sources for the facts on this sheet
- U.S. Food and Drug Administration. FDA Briefing Document: MOTS-c-Related Bulk Drug Substances (MOTS-c (free base) and MOTS-c acetate), Pharmacy Compounding Advisory Committee, July 23-24, 2026. Accessed 2026-10-18. https://www.fda.gov/media/193347/download
- Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun 2021. PMID 33473109. https://pubmed.ncbi.nlm.nih.gov/33473109/
- U.S. National Library of Medicine, ClinicalTrials.gov (API v2 record). NCT07505745: A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Pharmacodynamics of MOTS-c (a Mitochondrial-Derived Peptide) in Adults With Prediabetes and Overweight/Obesity. Accessed 2026-10-18. https://clinicaltrials.gov/api/v2/studies/NCT07505745
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.