HealthRX.com · Printable lab tracker
Autoimmune disease and NMN or NR: specialist, lab and symptom tracker
Agree a plan with your rheumatologist, gastroenterologist or neurologist before starting, then record disease scores, blood tests and symptoms at baseline, 4 weeks and 8 to 12 weeks, as the monitoring section of this page suggests. It also lists what the human NR studies did and did not test.
Before starting: agreed with your specialist
Condition and current activityquiet, mild, flaring
Current immune medicines and dosesmethotrexate, JAK inhibitor, mycophenolate, biologic, steroids
Product (NMN or NR) and daily amount
Specialist consulted, and date they agreed
Change in disease score that would mean stopping
Labs and scores
Baseline, 4 weeks and 8 to 12 weeks follow this page's suggested schedule; your specialist may choose different tests.
| Test | Baseline | 4 weeks | 8 to 12 weeks | Notes |
|---|---|---|---|---|
| Disease-activity score (DAS28, SLEDAI or Harvey-Bradshaw) | ||||
| CBC with differential | ||||
| CRP | ||||
| ESR | ||||
| Disease marker (anti-dsDNA for lupus, calprotectin for IBD) | ||||
Symptom diary
| Date | Joints, skin or gut symptoms | Fatigue | Fever, swollen glands or infection signs | Notes |
|---|---|---|---|---|
Report promptly to your specialist
- Any worsening of disease symptoms after starting
- New fever
- Swollen lymph glands
- Signs of an infection while on immunosuppression
- A change in your immune medicines while taking NMN or NR
What the human NR studies did and did not test
- Of the human NR studies on this sheet, the only one in an immune-mediated disease randomized 27 volunteers with mild-to-moderate psoriasis to NR 500 mg twice daily or placebo for 4 weeks.[1]
- It was built to study biological effects, not clinical benefit. NR was well tolerated and modestly lowered neutrophil counts.[1]
- In 140 healthy adults aged 40 to 60 taking 100, 300 or 1,000 mg/day NR for 8 weeks, no circulating cytokine or hs-CRP changed significantly.[2]
- The lupus findings come from patients' monocytes treated with NR in the laboratory, not from patients taking NR.[3]
Questions for your specialist
- Is my disease active enough that I should avoid NMN or NR for now?
- Could it change how my methotrexate, JAK inhibitor or mycophenolate works?
- Which tests should we repeat, and when?
- Should I stop it before a procedure, an infection, or a change in my treatment?
Sources for the facts on this sheet
- Han K, Klein RJ, Recupero TC, et al. NAD+ augmentation by nicotinamide riboside engages SLIT2/ROBO1 signaling to attenuate Th17 inflammation in psoriasis. JCI Insight 2026. PMID 42048163. https://pubmed.ncbi.nlm.nih.gov/42048163/
- Turck D, Bohn T, Castenmiller J, et al (EFSA Panel on Nutrition, Novel Foods and Food Allergens). Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021. PMID 34804232. https://pubmed.ncbi.nlm.nih.gov/34804232/
- Wu J, Singh K, Lin A, et al. Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes. J Clin Invest 2022. PMID 35025762. https://pubmed.ncbi.nlm.nih.gov/35025762/
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.