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HealthRX.com · Printable symptom log

MOTS-c reaction log for injection-site changes, tiredness and shaky spells

Forum posts rarely keep the details that let a reaction be interpreted. This log records the time since injection, a glucose reading if you have a meter, the vial's lot and how the reaction changed, so a clinician or a MedWatch report has something to work with.

Companion to “MOTS-c Side-Effect Reports From Real Users: What the Evidence Actually Shows” · healthrx.com/reviews-mots-c/side-effect-reports · Facts checked 2026-10-18

The vial

Product name and seller
Lot number and expiry date
How and when it was mixedliquid used and date reconstituted
How it has been stored since

Injection-site changes

Date and timeSiteSize of redness or swellingPain or burningHow long it lastedPhoto taken?

Shaky, sweaty or tired spells

A glucose reading taken during the spell is what turns a symptom into a measured result.

Date and timeMinutes since injectionSymptomsGlucose reading, if measuredWhat you didHow long it lasted

Reference points

  • MedlinePlus: blood sugar below 70 mg/dL (3.9 mmol/L) is considered low.[1]
  • MedlinePlus: below 54 mg/dL (3.0 mmol/L), more severe symptoms such as unclear thinking or seizure may occur.[1]
  • The MOTS-c glucose finding is from mice given injections for 7 days, not from people.[2]
  • FDA's July 2026 review identified no clinical studies or human exposure data for MOTS-c.[3]

Get help now

  • Severe low blood sugar is a medical emergency.[1]
  • If someone collapses, has a seizure, has trouble breathing or cannot be woken, call 911 right away.[4]

Before you report it

  • Keep the vial and any product left in it
  • Write down the lot number from the label
  • List every other medicine, supplement and drink taken that day
  • Note whether a fever or chills came with the reaction
  • File a MedWatch report with as much product detail as you have
Sources for the facts on this sheet
  1. U.S. National Library of Medicine, MedlinePlus. Low blood sugar: MedlinePlus Medical Encyclopedia. Accessed 2026-10-18. https://medlineplus.gov/ency/article/000386.htm
  2. Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab 2015. PMID 25738459. https://pubmed.ncbi.nlm.nih.gov/25738459/
  3. U.S. Food and Drug Administration. FDA Briefing Document: MOTS-c-Related Bulk Drug Substances (MOTS-c (free base) and MOTS-c acetate), Pharmacy Compounding Advisory Committee, July 23-24, 2026. Accessed 2026-10-18. https://www.fda.gov/media/193347/download
  4. National Capital Poison Center (Poison Control). Need Immediate Assistance? | Poison Control. Accessed 2026-10-18. https://www.poison.org/need-immediate-assistance

This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.