HealthRX.com · Printable side-effect diary
Four-clock diary for a symptom that started after MOTS-c
Keep the exposure, product, symptom and background clocks apart, as this page recommends. Dated entries let a clinician judge whether timing fits the product, the injection, or something unrelated, without guessing from memory.
Exposure clock
Write "unknown" rather than working an amount backwards from memory.
Date of first ever use
Date and time of the most recent use
Amount believed used each time, and route
First exposure, or one of a repeated series?
Product clock
Label name and stated strength
Seller or dispensing pharmacy
Lot number and beyond-use date
How it was stored since openingfridge, room temperature, travel
How the vial looks nowclear, cloudy, particles, color change
Symptom clock: dated entries
Use observations, not explanations such as "detox" or "immune reset".
| Date and time | Use or symptom | What you saw or measured (site, size, temperature) | Better, same or worse |
|---|---|---|---|
Background clock
Infections or fevers in the same weeks
Changes in exercise, food or alcohol
Prescribed medicines and supplements, with start dates
Other injections or procedures
Why the product clock matters
- FDA does not verify the safety, effectiveness or quality of compounded drugs before they are marketed.[1]
- Poor compounding practices can cause contamination, or too much or too little active ingredient, which can produce a symptom timeline that says little about MOTS-c itself.[1]
- FDA identified no repeat-dose toxicity studies of MOTS-c, so there is no known delayed-effect window to compare your dates against.[2]
- The only registered trial follows participants for safety through week 16 and has posted no results.[3]
When the diary can wait
- Possible excess dose: call Poison Control at 1-800-222-1222 (US) now, and do not wait for symptoms to develop.[4]
- Call 911 right away for collapse, a seizure, trouble breathing, or a person who cannot be woken.[5]
- On a Poison Control call, say at once if the person is unconscious or having difficulty breathing.[4]
Before the appointment
- Diary and product photos ready
- Vial, carton and any mixing instructions kept
- No further doses taken to test whether the symptom returns
- Questions written down for the clinician responsible for your care
Sources for the facts on this sheet
- U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers. Accessed 2026-10-18. https://www.fda.gov/drugs/human-drug-compounding/compounding-and-fda-questions-and-answers
- U.S. Food and Drug Administration. FDA Briefing Document: MOTS-c-Related Bulk Drug Substances (MOTS-c (free base) and MOTS-c acetate), Pharmacy Compounding Advisory Committee, July 23-24, 2026. Accessed 2026-10-18. https://www.fda.gov/media/193347/download
- U.S. National Library of Medicine, ClinicalTrials.gov (API v2 record). NCT07505745: A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Pharmacodynamics of MOTS-c (a Mitochondrial-Derived Peptide) in Adults With Prediabetes and Overweight/Obesity. Accessed 2026-10-18. https://clinicaltrials.gov/api/v2/studies/NCT07505745
- National Capital Poison Center. Get help online or by phone | Poison Control. Accessed 2026-10-18. https://www.poison.org/how-to-get-help-from-poison-control
- National Capital Poison Center. Need immediate assistance? | Poison Control. Accessed 2026-10-18. https://www.poison.org/need-immediate-assistance
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.