Minoxidil 1mg / Spironolactone 60mg

How it works

Minoxidil, in this formulation dosed at just 1mg, works systemically to widen blood vessels and extend the growth phase of the hair cycle. Spironolactone works differently: it blocks androgen receptors and a mineralocorticoid receptor, which reduces how much DHT can bind at the follicle and lowers scalp oil production. Neither is FDA-approved specifically for hair loss, and this is an off-label, compounded use of both. It's often used in women, since finasteride, the more familiar DHT-blocker, is contraindicated in anyone who is or could become pregnant.

What to expect

Most people notice visible change between eight and twelve weeks, with results continuing to build toward a peak around twelve to eighteen months. A 2023 review found improvement in 56.6 percent of women on spironolactone alone, rising to 65.8 percent when combined with minoxidil, though neither drug carries an FDA hair-loss approval and controlled trial data remain limited. Minoxidil's documented effects include low blood pressure, fluid retention, a faster heartbeat, unwanted hair growth elsewhere on the body, and temporary shedding; spironolactone's documented effects include elevated potassium, irregular periods, and breast tenderness.

Safety information

This product is compounded by a licensed pharmacy and is not FDA-approved. It has not undergone FDA review for safety or efficacy. It's absolutely contraindicated during pregnancy or breastfeeding, and in anyone with active cancer. Because spironolactone can raise potassium levels, your provider monitors potassium and kidney function with periodic blood tests, and will ask about low blood pressure, heart conditions, and any ACE inhibitor or ARB medications you take, since those combinations need extra caution. If your provider decides this combination isn't clinically appropriate for you, you won't be charged for the medication.