HealthRX.com · Printable question sheet
Goal-first sheet for adults 50 to 64 weighing MOTS-c
The page's advice is to name the concrete goal first and look at established causes and treatments. Use this sheet to do that with a clinician, and to record the product details if you already have one.
Your goal, and what has already been checked
One row per goal, such as glucose control, tiredness, exercise tolerance or weight.
| Goal | How it is measured now | Causes already looked into | Approved treatments already discussed | What is still open |
|---|---|---|---|---|
Health background that changes the picture
Blood pressure readings and any heart history
Diabetes or prediabetes results, with dates
Kidney and liver results, with dates
Cancer history
Menopause status, or testosterone or other hormone therapy
Current medicines and supplements
Include statins, metformin, GLP-1 medicines, blood-pressure tablets and anything bought without a prescription.
| Name | What it is for | Taken since |
|---|---|---|
If you already have a product labeled MOTS-c
Source and lot number
Stated concentration and the directions you were given
How it has been stored
Dates and amounts used so far
Symptoms since starting, with dates
What the age evidence shows
- In healthy men, blood MOTS-c was 11% lower in the 45-to-55 group and 21% lower in the 70-to-81 group than in men aged 18 to 30, while muscle expression was about 1.5-fold higher in both older groups.[1]
- Those men were free of chronic illness and took no medication, so the study says nothing about MOTS-c alongside common midlife conditions or medicines.[1]
- FDA's July 2026 review found no clinical studies or human exposure data for MOTS-c by any route.[2]
- The registered MOTS-c trial enrolls adults 18 to 65 and has posted no results.[3]
Questions to take to the appointment
- For the goal I wrote down, which established causes would you check first?
- Which of my current medicines would make it hardest to tell what caused a new symptom?
- Do my blood pressure, kidney or liver results add uncertainty to an unstudied product?
- Is there an approved treatment, tested in people in their fifties and early sixties, for this goal?
- If I already have a product, what should I bring next time?
Sources for the facts on this sheet
- D'Souza RF, Woodhead JST, Hedges CP, et al. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging (Albany NY) 2020. PMID 32182209. https://pubmed.ncbi.nlm.nih.gov/32182209/
- U.S. Food and Drug Administration. FDA Briefing Document: MOTS-c-Related Bulk Drug Substances (MOTS-c (free base) and MOTS-c acetate), Pharmacy Compounding Advisory Committee, July 23-24, 2026. Accessed 2026-10-18. https://www.fda.gov/media/193347/download
- U.S. National Library of Medicine, ClinicalTrials.gov (API v2 record). NCT07505745: A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Pharmacodynamics of MOTS-c (a Mitochondrial-Derived Peptide) in Adults With Prediabetes and Overweight/Obesity. Accessed 2026-10-18. https://clinicaltrials.gov/api/v2/studies/NCT07505745
This sheet records information for a conversation with your prescriber or pharmacist. It does not replace their instructions or the medication's prescribing information.