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- Ships in 3 to 5 days
Common questions
Low Dose Naltrexone (LDN)
Low dose naltrexone, dosed to the milligram.
Low dose naltrexone (LDN) · 1.5 to 4.5 mg
- Compounded to your dose
- One nightly capsule
- Studied for inflammation
- Provider-titrated
Find the plan that fits you.
Answer three quick questions to match your priorities and budget. Get your recommendation and free treatment guide by text. No card to start.
Purchase type
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Cadence
Strength set by your provider. They confirm the right strength and dose after reviewing your required post-purchase intake.
Payment does not guarantee a prescription. Complete the required pharmacist intake after purchase.
What's included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your low-dose naltrexone ships.
Dosed to the milligram
Compounded by a US-licensed pharmacy to your precise low dose, usually 1.5 to 4.5 mg.
One capsule at night
Taken once a day, most often at bedtime.
Studied for inflammation and immune balance
Small human trials have looked at low-dose naltrexone in fibromyalgia and Crohn's disease, summarized in the research section.
Provider-titrated
A US-licensed provider prescribes it off-label and steps your dose up gradually.
About Low Dose Naltrexone (LDN)
Full-dose naltrexone blocks opioid receptors. A small fraction of that dose is studied for a different effect: a brief blockade that may prompt your body to raise its own endorphins and calm inflammatory signaling. Your provider starts you low and adjusts over time, and the pharmacy compounds your exact dose.
- Compounded to your precise low dose
- Studied for inflammation and immune balance
- One capsule a day, usually at night
- Real pricing up front, message your provider anytime
Naltrexone is an opioid receptor antagonist, used off-label at low doses. Compounded by a US-licensed pharmacy.
A brief receptor block
At low doses, naltrexone briefly blocks opioid receptors for a few hours.
An endorphin rebound
Your body responds by raising its own endorphins.
Calmer immune signaling
Low-dose naltrexone is also thought to quiet inflammatory signaling from immune cells called microglia.
A short blockade that may prompt your own endorphins and calm inflammatory signaling. The mechanism is still being studied.
How to get it
Today
Take the quiz
Share your history and goals, and note any opioid use.
Next
A provider reviews
A US-licensed provider reviews your history and, if appropriate, prescribes a low starting dose off-label.
3 to 5 days
The pharmacy compounds
Your exact dose is compounded and ships to your door in 3 to 5 days.
Ongoing
Titrate and check in
Step up gradually and message your provider along the way.
What the research shows
Naltrexone is an established opioid antagonist, and at very low doses it is prescribed off-label for inflammation and immune balance. The human evidence comes from small trials, summarized below. These studies are early and modest in size rather than large confirmatory trials.
28.8% vs 18.0%
Reduction in daily pain with low-dose naltrexone versus placebo in a double-blind crossover trial of 31 women with fibromyalgia.
Younger et al., Arthritis and Rheumatism, 2013
88% vs 40%
Clinical response in active Crohn's disease with low-dose naltrexone versus placebo in a randomized trial of 40 adults.
Smith et al., Digestive Diseases and Sciences, 2011
Low-dose naltrexone (1.5 to 4.5 mg) or Standard naltrexone (50 mg)
Low dose is a different tool from standard naltrexone
| Low-dose naltrexone (1.5 to 4.5 mg) | Standard naltrexone (50 mg) | |
|---|---|---|
| Dose | 1.5 to 4.5 mg | 50 mg |
| Opioid receptor block | Brief and partial | Full and all day |
| Typical use | Inflammation and immune balance, off-label | Opioid and alcohol use disorder |
| When taken | At night | Once daily, any time |
| Form | Compounded to your dose | Standard tablet |
| Goal | Endorphin rebound | Sustained opioid blockade |
What to expect
Vivid dreams or lighter sleep can show up early and usually settle. Your provider tracks your response over the following weeks.
- Week 1 to 2
Start at 1.5 mg
Begin at the lowest dose, taken at night.
- Week 2 to 4
Settle your sleep
Vivid dreams or lighter sleep can show up early and usually settle; some take the dose earlier in the evening.
- Week 4 to 8
Titrate up
Your provider steps the dose toward 3 to 4.5 mg as you tolerate it.
- Ongoing
Find your dose
Your provider tunes the dose to how you respond.
Safety and side effects
Not prescribed with opioid medication. Your provider reviews everything you take first and starts you low.
Common
- Vivid dreams
- Lighter or disrupted sleep
- Mild headache
- Nausea
Less common
- Daytime fatigue or grogginess
- Dizziness
- Stomach cramps or diarrhea
Seek care
- Opioid withdrawal if you are taking or recently took opioids
- Loss of effect from opioid pain medicines, which matters in an emergency or before surgery
Do not take low-dose naltrexone with opioid pain medication. It can block those medicines and, if you have opioids in your system, bring on withdrawal. Tell any provider or surgeon that you take it before procedures.
Frequently asked questions
Other longevity options
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.