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- Ships in 3 to 5 days
Common questions
Rapamycin (Sirolimus)
The longevity molecule, prescribed.
Rapamycin (sirolimus) · 1 mg
- Targets mTOR
- Weekly, not daily
- Provider-set dose
- Studied in aging research
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Purchase type
Save 10% today and on every refill. Auto-renews at your selected cadence, pause or cancel anytime.
Cadence
Strength set by your provider. They confirm the right strength and dose after reviewing your required post-purchase intake.
Payment does not guarantee a prescription. Complete the required pharmacist intake after purchase.
What's included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your rapamycin ships.
Targets the mTOR pathway
Rapamycin inhibits mTOR, a central regulator of how your cells balance growth and repair.
A weekly protocol
Longevity dosing is low and intermittent, usually once a week, set by your provider rather than taken daily.
At the center of aging research
Rapamycin is the most studied molecule in the field, though most of that evidence is from laboratory models and human longevity trials are still early.
Provider-set and monitored
A US-licensed provider prescribes it off-label and monitors labs such as lipids and blood counts.
About Rapamycin (Sirolimus)
Rapamycin is the molecule at the center of longevity research, because it inhibits mTOR, a pathway that governs how cells balance growth and repair. It is prescribed off-label, typically on a weekly protocol your provider sets. Reviewed by a licensed provider, compounded by a US-licensed pharmacy.
- Inhibits the mTOR longevity pathway
- Weekly protocol set by your provider
- The most-studied molecule in the space
- Provider-reviewed, real pricing up front
Rapamycin (sirolimus) inhibits the mTOR pathway, which regulates cell growth, metabolism and autophagy. Compounded by a US-licensed pharmacy.
Binds FKBP12
Rapamycin pairs with a protein called FKBP12 inside your cells.
Inhibits mTORC1
That pairing blocks mTORC1, a hub that drives cell growth.
Shifts toward repair
With growth signaling turned down, cells lean toward maintenance and autophagy, their cleanup process.
In laboratory studies this shifts cells from growth toward repair. Whether that translates to longevity in people is still being studied.
How to get it
Today
Take the quiz
Share your history and goals in a few minutes.
Next
A provider reviews
A US-licensed provider reviews your history and, if appropriate, prescribes a weekly protocol off-label.
3 to 5 days
The pharmacy ships
Your dose is compounded and ships to your door in 3 to 5 days.
Ongoing
Follow-up labs
Your provider checks lipids and blood counts and adjusts the protocol.
Weekly longevity protocol or Daily transplant dosing
Why longevity dosing looks different from transplant dosing
| Weekly longevity protocol | Daily transplant dosing | |
|---|---|---|
| Dose size | Low | High |
| How often | Usually once a week | Every day |
| Immune suppression | Kept low by the dose | Strong, intended |
| Goal | Dial down mTOR intermittently | Prevent organ rejection |
| Monitoring | Periodic labs | Intensive drug-level monitoring |
| Prescribed | Off-label, provider-set | On-label immunosuppression |
What to expect
This is a long-horizon protocol rather than something you feel day to day. Your provider sets the cadence and monitors you over time.
- Week 1
Start your protocol
Begin the weekly dose your provider sets.
- Week 2 to 4
Watch tolerance
Note any mouth sores or stomach changes and message your provider.
- Week 6 to 8
Check labs
Your provider reviews your lipids and blood counts.
- Ongoing
Adjust the dose
Your provider tunes the protocol to how you respond.
Safety and side effects
Prescribed off-label and not right for everyone. Rapamycin is an immunosuppressant, so it can raise infection risk; avoid live vaccines while on it. It interacts with grapefruit and CYP3A4 medications, which change its levels. Tell your provider about infections and every medication.
Common
- Mouth sores or canker sores
- Higher cholesterol or triglycerides
- Mild nausea or diarrhea
- Acne-like skin bumps
Less common
- Slower wound healing
- Mild swelling in the legs or ankles
- Changes in blood counts
Seek care
- Higher risk of infection from immune modulation
- Lung inflammation, a rare but serious reaction that needs prompt care
Rapamycin interacts with grapefruit and many medicines through the CYP3A4 pathway, so share your full medication list. Your provider monitors lipids and blood counts, and the protocol is paused around surgery or active infection. Live vaccines are avoided while taking it.
Frequently asked questions
Other longevity options
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
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Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.