What does metformin do for metabolism?

It lowers the glucose your liver releases and improves how your body responds to insulin, partly by activating an energy-sensing pathway called AMPK.

Is metformin safe for people without diabetes?

It has decades of safety data. Use outside diabetes is off-label and reviewed by a provider, who checks kidney function and monitors B12 over time.

What are metformin side effects?

The most common are digestive, especially early on. The extended-release form and taking it with food reduce this for most people.

Concentration: Metformin ER 500 mg
Purity: Provider reviewed
Unit: 180 tablets
Category: Longevity

Longevity

Metabolic Rx

The metabolic workhorse, prescribed.

Metabolic Rx · Metformin ER 500 mg

Purchase type

Save 10% today and on every refill. Auto-renews at your selected cadence, pause or cancel anytime.

Cadence

Metabolic Rx$134 billed monthly

Strength set by your provider. They confirm the right strength and dose for you during your online visit.

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Only available if prescribed after an online consultation with a licensed provider.

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✓Medication and supplies
✓Provider visit and unlimited follow-ups
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About Metabolic Rx

Metformin is one of the most-prescribed and best-understood medications in the world, and its effect on insulin sensitivity and metabolism has made it a fixture of longevity interest. The extended-release form is gentler on the stomach. Reviewed by a licensed provider, dispensed by a US-licensed pharmacy.

How it works

Answer a few questions. Your provider reviews your history and, if appropriate, prescribes metformin ER. The pharmacy dispenses it; message your care team anytime.

What to expect

Some stomach upset is possible early and eases with the extended-release form and taking it with food. Your provider sets the dose.

✓Improves insulin sensitivity
✓Extended-release, gentler on the stomach
✓Decades of safety data
✓Provider-reviewed, real pricing up front

Evidence notes

Metformin reduces hepatic glucose output and improves insulin sensitivity, partly via AMPK activation. Dispensed by a US-licensed pharmacy.

Safety information

Reviewed by a licensed provider. Not used with significantly reduced kidney function (rare risk of lactic acidosis), and paused around contrast imaging or acute illness. Tell your provider about kidney function and alcohol use; B12 is monitored long term.

Frequently asked questions

Metformin is prescribed off-label in longevity protocols for its effects on insulin sensitivity and metabolism, alongside its established diabetes use. A provider reviews suitability.

Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.