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47 clinically reviewed articles, written and peer-reviewed by the HealthRX.com Medical Team.
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Showing 47 of 47 clinical reviews.
A clinician-reviewed guide to Addison's disease covering primary and secondary adrenal insufficiency, cortisol replacement, fludrocortisone dosing, adrenal crisis recognition, and when to seek emergency care.
Read clinical reviewA comprehensive clinical guide to adrenal adenomas covering incidental discovery, hormonal workup, Cushing syndrome, Conn syndrome, Addison disease, secondary adrenal insufficiency, and evidence-based management options.
Read clinical reviewA clinician-reviewed guide to HPA axis physiology and cortisol management across pregnancy, pediatric populations, long-term steroid users, and athletes with HPA dysfunction. Includes doses, timelines, and evidence-based protocols.
Read clinical reviewA clinician-reviewed guide to adrenal cortisol physiology, lab testing, high and low cortisol disorders, and evidence-based treatments with specific drug names, doses, and trial data.
Read clinical reviewLearn how to recognize adrenal crisis symptoms, distinguish them from steroid withdrawal syndrome, and act fast. Reviewed by board-certified physicians.
Read clinical reviewA board-reviewed guide to adrenal crisis: what triggers it, how to recognize early warning signs, emergency hydrocortisone dosing, and how to prevent life-threatening adrenal collapse in Addison's disease and secondary adrenal insufficiency.
Read clinical reviewA clinical deep-dive into hypothalamic-pituitary-adrenal axis dysfunction in athletes, covering overtraining, relative energy deficiency in sport, pregnancy, pediatric cases, and long-term steroid users. Reviewed by HealthRX.com physicians.
Read clinical reviewChronic stress reshapes your HPA axis, not your adrenal glands. Learn what cortisol actually does, whether adrenal fatigue is real, how to test for Cushing's, and what normal AM cortisol levels look like.
Read clinical reviewA clinician-reviewed guide to congenital adrenal hyperplasia (CAH): the enzyme defects behind it, how it differs from Addison's disease and Cushing's syndrome, and the specific glucocorticoid regimens used to treat it.
Read clinical reviewA detailed breakdown of hydrocortisone costs for adrenal insufficiency, including generic vs. brand pricing, insurance coverage, patient assistance programs, and money-saving strategies.
Read clinical reviewCushing's disease is caused by a pituitary adenoma secreting excess ACTH. Learn how it differs from Cushing's syndrome, Addison's disease, and adrenal crisis, plus current diagnostic criteria and treatment options.
Read clinical reviewA clinician-reviewed guide to Cushing's syndrome covering cortisol excess, ACTH-dependent vs independent causes, diagnostic testing, treatment options, and adrenal crisis prevention.
Read clinical reviewA clinician-reviewed guide to dexamethasone covering FDA-approved uses, dosing, potency comparisons with prednisone and hydrocortisone, side effects, and when fludrocortisone is needed instead.
Read clinical reviewA clinical comparison of DHEA supplementation versus no DHEA in Addison's disease, covering trial data, quality-of-life outcomes, dosing protocols, and how DHEA fits alongside hydrocortisone and fludrocortisone regimens.
Read clinical reviewAdrenal insufficiency vs. Addison's disease explained by the HealthRX.com medical team. Covers cortisol physiology, normal AM cortisol ranges, adrenal fatigue evidence, and Cushing's testing protocols.
Read clinical reviewCaffeine does raise cortisol, but the size and duration of the spike depend on dose, tolerance, timing, and individual stress physiology. Here is what clinical evidence says about caffeine and cortisol.
Read clinical reviewA clinician-reviewed guide to fludrocortisone (Florinef) covering mechanism, approved indications, dosing, side effects, monitoring, and comparisons with hydrocortisone, prednisone, prednisolone, and dexamethasone.
Read clinical reviewA physician-reviewed guide to Cushing's syndrome testing, normal AM cortisol ranges, the truth about adrenal fatigue, and what causes low cortisol. Includes specific labs, cutoffs, and next steps.
Read clinical reviewA detailed breakdown of Cushing's syndrome drug costs, from mifepristone (Korlym) and osilodrostat (Isturisa) to off-label ketoconazole and hydrocortisone replacement therapy.
Read clinical reviewA step-by-step guide to requesting cortisol testing from your doctor, including which tests to ask for, how to frame your symptoms, and what results actually mean.
Read clinical reviewA clinician-reviewed guide to HPA axis dysfunction covering the full spectrum from Addison's disease and secondary adrenal insufficiency to Cushing's syndrome and subclinical dysregulation, with diagnostic thresholds, named trials, and treatment protocols.
Read clinical reviewA clinician-reviewed guide to hydrocortisone (Cortef) covering FDA-approved uses, physiologic vs. stress dosing, corticosteroid comparisons, side effects, and adrenal insufficiency management protocols.
Read clinical reviewEvidence-based guide to hydrocortisone replacement dosing for adrenal insufficiency, including stress dose protocols, sick day rules for Addison's disease, and safe prednisone tapering.
Read clinical reviewA physician-reviewed comparison of hydrocortisone and prednisone covering potency, dosing, adrenal replacement, modified-release formulations, and DHEA add-on therapy for Addison's disease.
Read clinical reviewA clinician-reviewed guide to the HPA axis covering normal physiology, Addison's disease, secondary adrenal insufficiency, Cushing's syndrome, and Cushing's disease, with specific doses, trials, and diagnostic thresholds.
Read clinical reviewAdrenal fatigue is not a recognized medical diagnosis. The real condition behind your symptoms is HPA axis dysregulation, a measurable dysfunction in cortisol signaling. Here is what the science says and what to do about it.
Read clinical reviewA clinician-reviewed guide to ketoconazole for Cushing's syndrome covering mechanism, dosing, monitoring, liver safety, and comparisons with hydrocortisone, prednisone, prednisolone, and dexamethasone.
Read clinical reviewA clinician-reviewed guide to mifepristone (Korlym) for Cushing's syndrome, including FDA-approved dosing, side effects, monitoring, and comparisons with hydrocortisone, prednisone, prednisolone, and dexamethasone.
Read clinical reviewA clinician-reviewed guide to mitotane (Lysodren) for adrenocortical carcinoma, covering mechanism, dosing, cortisol monitoring, and replacement therapy with hydrocortisone, prednisone, and dexamethasone.
Read clinical reviewA clinical comparison of modified release hydrocortisone (Plenadren, Chronocort) versus conventional immediate-release hydrocortisone for adrenal insufficiency, including dosing, outcomes, and DHEA replacement evidence.
Read clinical reviewLong-term corticosteroid use in older adults raises risks of osteoporosis, adrenal suppression, and metabolic harm. Learn evidence-based monitoring, tapering protocols, and protective strategies.
Read clinical reviewEvidence-based review of osilodrostat (Isturisa) for Cushing's disease: mechanism, dosing, efficacy from LINC 3 and LINC 4 trials, safety, and how it compares to hydrocortisone, prednisone, and other corticosteroids.
Read clinical reviewA board-reviewed clinical guide to pasireotide (Signifor and Signifor LAR) for Cushing's disease and acromegaly, with direct comparisons to hydrocortisone, prednisone, prednisolone, and dexamethasone across dosing, adrenal suppression, and safety.
Read clinical reviewA clinically detailed guide to pheochromocytoma covering epidemiology, biochemical testing, imaging, surgical management, and links to Addison's disease, Cushing's syndrome, and secondary adrenal insufficiency.
Read clinical reviewPost-steroid adrenal suppression occurs when exogenous glucocorticoids shut down the HPA axis. Learn how long recovery takes, how to taper safely, and when secondary adrenal insufficiency requires hormone replacement.
Read clinical reviewA clinician-reviewed guide to prednisolone covering indications, dosing, side effects, and how it differs from prednisone, hydrocortisone, dexamethasone, and fludrocortisone (Florinef).
Read clinical reviewA physician-reviewed guide to prednisone covering approved uses, dosing ranges, side effects, tapering, and comparisons with hydrocortisone, prednisolone, dexamethasone, and fludrocortisone.
Read clinical reviewSecondary adrenal insufficiency occurs when the pituitary gland fails to produce enough ACTH, leaving the adrenal glands starved of their main signal. Learn causes, symptoms, diagnosis workup, and hydrocortisone dosing from HealthRX.com's clinical team.
Read clinical reviewAdaptogens are widely marketed for 'adrenal support,' but what does the clinical evidence actually show? Learn what cortisol does, how to test it properly, and when adaptogens may or may not help.
Read clinical reviewA physician-reviewed guide to sick day rules for Addison's disease covering hydrocortisone stress dosing, injectable emergency protocols, and when to go to the ER.
Read clinical reviewSteroid withdrawal syndrome causes fatigue, joint pain, low cortisol, and adrenal crisis risk. Learn the symptoms, timeline, and evidence-based tapering strategies reviewed by the HealthRX.com medical team.
Read clinical reviewEvidence-based stress dose steroid protocols for adrenal insufficiency, Addison's disease, and surgical patients. Covers hydrocortisone dosing, sick day rules, perioperative coverage, and safe prednisone tapering with cited guidelines.
Read clinical reviewA complete, physician-reviewed guide to tapering prednisone safely, including dose reduction schedules, hydrocortisone replacement dosing, stress dose steroid protocols, and sick day rules for adrenal insufficiency.
Read clinical reviewLow cortisol can result from autoimmune adrenal destruction, pituitary disorders, or long-term steroid withdrawal. Learn the causes, testing, and when to seek treatment.
Read clinical reviewCortisol regulates metabolism, immune response, and stress adaptation. Learn what normal levels look like, how testing works, and what happens when cortisol is too high or too low.
Read clinical reviewMissing a dose of hydrocortisone can trigger adrenal crisis in patients with adrenal insufficiency. Learn the risks, symptoms, and emergency steps for skipped cortisol replacement.
Read clinical reviewNormal morning cortisol ranges from 6 to 18 mcg/dL when drawn between 7 and 9 AM. Learn what cortisol does, what abnormal results mean, and how doctors test for Cushing syndrome and adrenal insufficiency.
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