Welche Senolytika sind sicher? Dasatinib, Quercetin, Navitoclax
Keine Senolytika haben Phase-3-Studien bestanden. Alle zeigten Nebenwirkungen, von Thrombozytopenie bis Magen-Darm-Beschwerden. Die Evidenzlage im Detail.
Should Healthy People Take Rapamycin?
A breakdown of whether healthy adults should use rapamycin for longevity, covering human trial data, dosing protocols, side-effect profiles, biological age testing, senolytics, and metformin as comparators.
Spermidine: The Autophagy-Activating Compound Behind Longevity Research
Spermidine triggers autophagy, reduces cardiovascular risk, and may extend healthspan. Learn the evidence-backed doses, food sources, and how it compares to rapamycin, metformin, NR, and NMN.
Those With Family History of Dementia: What the Evidence Says About Prevention, HRT, and Brain Health
If a parent or sibling had dementia, your risk is real but not fixed. This clinically reviewed guide covers genetic risk, the critical hormone timing window, lifestyle evidence, and actionable steps for adults over 50 with a family history of dementia.
What Is Biological Age and Can You Measure It?
Biological age reflects how well your cells, organs, and epigenome are functioning, not how long you have been alive. Learn which tests measure it accurately, what the evidence says about slowing it, and which longevity drugs are ready for clinical use.
What Labs Predict Biological Age
A guide to the blood tests, epigenetic clocks, and organ-function panels that measure biological age, plus what is and is not established about rapamycin, metformin, and senolytics as interventions on those numbers.
Losartan Hair and Skin Changes: What Patients and Clinicians Need to Know
A clinical deep-dive into losartan's documented effects on hair and skin, including alopecia, psoriasiform reactions, and rare dermatologic adverse events, with primary-literature citations and prescriber guidance.
How to Get Low-Dose Naltrexone in Virginia
A guide to obtaining a low-dose naltrexone (LDN) prescription in Virginia, covering telehealth options, compounding pharmacy requirements, labs, dosing, and insurance coverage.
Low-Dose Naltrexone: What to Expect Week by Week in Your First Month
Your first month of low-dose naltrexone: weekly symptom tracking, sleep and side effects, prescription checks and the month-one treatment review.
Low-Dose Naltrexone Seasonal Use Considerations
A clinician-level guide to adjusting low-dose naltrexone (LDN) dosing, timing, and monitoring across seasons, covering winter immune shifts, summer heat effects, and condition-specific seasonal flare patterns.
Low-Dose Naltrexone Switching Protocols: How to Transition From or To Other Drugs in Class
A guide to switching low-dose naltrexone (LDN) from or to other opioid-antagonist and opioid-agonist medications, covering mechanism, timing risk, washout windows, and compounding considerations, with an emphasis on where evidence is solid and where it is not.
Low-Dose Naltrexone and Liver Function: What the Evidence Actually Shows
A guide to how low-dose naltrexone (LDN) affects liver enzymes and hepatic safety, covering clinical trial data, FDA labeling, monitoring protocols, and who should avoid LDN entirely.
Low-Dose Naltrexone Muscle Preservation Strategies: A Clinical Deep-Dive
How low-dose naltrexone (LDN) may support muscle preservation through glial modulation, cytokine reduction, and IGF-1 pathway effects. MD/PharmD-level review with primary literature, dosing guidance, and a decision framework.
Low-Dose Naltrexone: Restarting After Acute Illness
A clinician-level guide to safely restarting compounded low-dose naltrexone (LDN) after an acute illness, including when to pause, how to re-titrate, and what the evidence says about opioid receptor modulation and immune function.
Low-Dose Naltrexone Pre-Surgery Hold Window: What Clinicians and Patients Need to Know
How long before surgery should you stop low-dose naltrexone? This MD/PharmD-level guide covers the evidence-based hold window, opioid-antagonism pharmacokinetics, anesthesia risks, and restart timing after your procedure.
Low-Dose Naltrexone Travel and Timezone-Shift Protocols
A guide to adjusting compounded low-dose naltrexone (LDN) dosing times during air travel, crossing multiple time zones, and managing circadian disruption without losing therapeutic benefit.
Bremelanotide PT-141: How It Works, Dosing, and How It Compares to Sildenafil, Tadalafil, Vardenafil, and Avanafil
A guide to bremelanotide (PT-141) covering its melanocortin mechanism, FDA-approved dosing, side effects, and a head-to-head comparison with PDE5 inhibitors sildenafil, tadalafil, vardenafil, and avanafil for erectile dysfunction.
PDE5 Inhibitor Onset Times: Sildenafil, Tadalafil, Vardenafil, Avanafil Compared
How fast do PDE5 inhibitors work? Compare onset times, peak effect windows, and duration for sildenafil, tadalafil, vardenafil, and avanafil. Includes daily vs. on-demand tadalafil dosing, Trimix injection protocols, and PT-141 dosing for ED.
PDE5 Inhibitor Side Effects: A Complete Clinical Guide
A guide to every common and serious side effect of PDE5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil), including NAION, priapism, and Trimix injection complications, with dosing thresholds and emergency management steps.
Penile Implants: Types, Surgery, Recovery, and How They Compare to ED Pills
A guide to penile implants covering inflatable and malleable devices, surgical outcomes, satisfaction rates, and how implants compare to sildenafil, tadalafil, vardenafil, and avanafil.
Pentoxifylline for Peyronie's Disease: Dosing, Evidence, and What to Expect
A guide to pentoxifylline for Peyronie's disease covering mechanism, dosing, the strength of clinical evidence, combination therapy with PDE5 inhibitors, and when to consider escalation to injection or surgery.
Peyronie's Disease: Causes, Diagnosis, and Treatment Options
A guide to Peyronie's disease covering penile curvature causes, scar tissue formation, diagnosis criteria, collagenase injections, surgery, and how the condition intersects with erectile dysfunction and low libido.
Premature Ejaculation: Causes, Diagnosis, and Treatment Options That Work
A guide to premature ejaculation covering DSM-5 criteria, IELT thresholds, dapoxetine, SSRIs, topical agents, behavioral techniques, and when PE overlaps with ED, low libido, or Peyronie's disease.
Priapism Emergency Management: What to Do, When to Act, and How to Prevent It
A guide to priapism emergency management covering time-to-treatment windows, aspiration and phenylephrine protocols, PDE5 inhibitor side effects, Trimix injection complications, and NAION risk.
Priapism: Causes, Types, Emergency Treatment, and Long-Term Management
A complete clinical guide to priapism covering ischemic vs. nonischemic types, emergency aspiration, intracavernosal phenylephrine, surgical shunting, and how priapism relates to erectile dysfunction, testosterone, and GLP-1 medications.
PT-141 vs PDE5 Inhibitors: Which ED Treatment Is Right for You?
A detailed clinical comparison of PT-141 (bremelanotide) vs PDE5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil) covering mechanism, dosing, efficacy data, side effects, and how to choose.
Tadalafil Daily vs On-Demand Dosing: Which Protocol Is Right for You?
A comparison of tadalafil 2.5 to 5 mg daily dosing versus 10 to 20 mg on-demand dosing for erectile dysfunction, including onset times, PDE5 inhibitor comparisons, Trimix protocols, and PT-141 dosing guidance.
Topical Lidocaine for Premature Ejaculation: Does It Work, How to Use It, and What to Expect
A guide to topical lidocaine for premature ejaculation, covering evidence from randomized trials, correct application technique, dosing, side effects, and how it compares with PDE5 inhibitors like sildenafil, tadalafil, vardenafil, and avanafil.
Yohimbine for Erectile Dysfunction: What the Evidence Actually Shows
A guide to yohimbine for ED, including how it compares to sildenafil, tadalafil, vardenafil, and avanafil, with dosing, side effects, and evidence from named trials.
Acne on TRT: Causes, Treatment, and When to Call Your Doctor
Testosterone replacement therapy can trigger or worsen acne in some men. Learn why it happens, which treatments work, and how to manage it without stopping TRT.
Anastrozole Dosing for TRT: The Evidence-Based Guide to Estrogen Management
What current labeling, guidelines, and male TRT research can—and cannot—establish about anastrozole dose decisions, estradiol results, monitoring, and tradeoffs.
Aromasin (Exemestane) on TRT: Dosing, Benefits, and How It Compares to Anastrozole
An evidence map for off-label exemestane during testosterone therapy: what the current label and small male studies establish, what remains unknown, and what a prescribing decision must consider.
Aromatization and the Estrogen Pathway in Men: What Happens to Your Testosterone
A complete clinical guide to aromatization, the estrogen pathway, SHBG, free vs total testosterone, and HPG axis suppression in men on TRT. Includes dosing context, lab interpretation, and management strategies.
Blood Pressure on TRT: What the Evidence Actually Shows
Does testosterone replacement therapy raise blood pressure? Learn what the TRAVERSE trial found, how hematocrit and estradiol affect cardiovascular risk, and what monitoring your CBC and hormone panel actually requires.
Can You Drink Alcohol on TRT?
A guide covering alcohol and TRT interactions, how fast TRT works, stopping TRT safely, and which supplements pair well with testosterone therapy.
Can You Stop TRT Cold Turkey? What Happens and How to Quit Safely
Stopping TRT abruptly triggers a predictable hormonal crash. Learn what happens when you quit testosterone cold turkey, how to taper safely, and what to expect during recovery, backed by clinical evidence.
Can You Take TRT With Blood Thinners? Risks, Drug Interactions, and What to Monitor
Testosterone replacement therapy can raise clotting risk and change how the body handles anticoagulant drugs. Here is what the evidence supports about TRT and warfarin, DOACs, hematocrit, and what to monitor.
TRT Monitoring Schedule: Labs, Timing and Correct Frequency
TRT monitoring is hematocrit and PSA at 3-6 months, not monthly hematocrit. See full baseline and follow-up lab schedule with target ranges.
Cycle Off TRT: How to Safely Stop Testosterone Replacement Therapy
A complete clinical guide to cycling off TRT, including standard protocols, daily microdosing, intramuscular vs subcutaneous injection technique, and what to expect when you stop testosterone therapy.
Cypionate vs Enanthate: Which Testosterone Ester Should You Use for TRT?
A clinical comparison of testosterone cypionate and enanthate for TRT, covering half-life, injection frequency, side effects, cost, and how both stack up against gels, clomid, and enclomiphene.
Testosterone Cypionate vs. Pellets: Which TRT Delivery Method Is Right for You?
A clinical comparison of testosterone cypionate injections and subcutaneous pellets for TRT, covering pharmacokinetics, cost, reversibility, dosing flexibility, and how each stacks up against enclomiphene, Clomid, and enanthate.
TRT Dose Titration: Match the Blood Test to the Prescription
Make TRT blood tests interpretable: match draw timing to your prescription, distinguish midpoint from trough, and review dose changes with useful context.
TRAVERSE Showed TRT Non-Inferiority for MACE. That Is Not the Same as Cardiovascular Safety.
The TRAVERSE trial is the largest RCT ever conducted on testosterone therapy and cardiovascular outcomes. It does not, however, give clinicians permission to skip careful CV risk stratification before initiating TRT. Here is why the HealthRX.com Medical Team screens exactly as before.
Enclomiphene: How It Compares to Testosterone Cypionate, Enanthate, Propionate, and Pellets for Men's TRT
A clinical deep-dive into enclomiphene for men's testosterone optimization, covering mechanism, dosing, side effects, and how it stacks up against testosterone cypionate, enanthate, propionate, and pellet therapy.
Erythrocytosis and Elevated Hematocrit on TRT: Causes, Risks, and Management
TRT raises hematocrit in up to 40% of men. Learn why erythrocytosis happens, what hematocrit levels are dangerous, and how clinicians manage it with dose adjustments, phlebotomy, and monitoring protocols.
Estradiol Sensitive Assay: The Complete TRT Lab Guide for Men
How the estradiol sensitive assay (LC-MS/MS) differs from a standard estradiol immunoassay, why the distinction matters for men on testosterone replacement therapy, and how to read an estradiol result alongside total testosterone, free testosterone, CBC, and lipid values.
Free Testosterone Calculation: How to Interpret Your TRT Lab Results
Learn how free testosterone is calculated, what the Vermeulen equation means, which labs to order on TRT, and how to interpret total testosterone, SHBG, estradiol, CBC, and lipid results with specific reference ranges and clinical guidance.
HCG vs Enclomiphene: Which Is Right for Your TRT Protocol?
A clinical comparison of HCG and enclomiphene for men on TRT or seeking to preserve fertility and natural testosterone production. Doses, mechanisms, evidence, and decision framework included.
HPG Axis Suppression: Free vs Total Testosterone, SHBG, and the Aromatization Pathway Explained
A guide to HPG axis suppression on TRT, covering free vs total testosterone, bioavailable testosterone, SHBG, and estrogen aromatization with primary-source citations throughout.
TRT Injection Technique: Intramuscular, Subcutaneous, Dose Titration, and Microdosing Protocols
A guide to testosterone injection technique for TRT, covering intramuscular vs subcutaneous routes, standard protocols, daily microdosing, needle selection, site rotation, and dose titration with primary-source citations.
Insurance Coverage for TRT: What Medicare, Private Plans, and Telehealth Actually Pay
A guide to TRT insurance coverage, prior authorization requirements, Medicare rules, monthly cost ranges, and how to reduce out-of-pocket expenses in 2025.
Intramuscular vs Subcutaneous Testosterone Injections: Which Route Is Right for Your TRT Protocol?
A clinical comparison of intramuscular and subcutaneous testosterone injection routes for TRT, covering pharmacokinetics, technique, dosing, and how to choose the right protocol with your prescriber.
LH and FSH on TRT: What Your Lab Numbers Actually Mean
LH and FSH drop to near-zero on TRT. Learn what suppressed gonadotropins mean for fertility, testicular size, and monitoring, plus the full lab panel every TRT patient needs.
Lipid Panel on TRT: What Your Labs Mean and How to Interpret Them
A complete clinical guide to reading your lipid panel on testosterone replacement therapy, including how TRT affects HDL, LDL, triglycerides, and what ranges to target. prepared by the HealthRX.com Editorial Team.
Morning or Evening TRT? Match the Lab to the Formulation
Morning or evening TRT? Learn why the product and time since your last injection matter when scheduling and comparing testosterone blood tests.
SHBG Explained: What Sex Hormone-Binding Globulin Means for Your Testosterone
A complete clinical guide to SHBG: how it binds testosterone, why free and bioavailable testosterone matter more than total T, how the HPG axis is affected, and what your lab numbers actually mean.
Standard TRT Protocol: Doses, Injection Schedules, and How to Titrate
A guide to the standard TRT protocol for men, covering testosterone cypionate and enanthate dosing, IM vs. subcutaneous injection technique, daily microdosing, and lab-based dose titration.
Testosterone Compounded Cream: What It Is, How It Works, and How It Compares to Other TRT Forms
A guide to testosterone compounded cream for men, covering absorption, dosing, how it stacks up against cypionate injections, pellets, and other formulations, with evidence from named trials and FDA-cleared references.
Testosterone Enanthate: Dosage, Injection Schedule, and How It Compares to Other TRT Forms
A guide to testosterone enanthate for TRT: how it works, standard doses, injection frequency, side effects, and how it compares to cypionate, propionate, pellets, and gels.
Testosterone Receptor Mechanism: How T Works Inside Your Cells
A guide to how testosterone binds androgen receptors, how the HPG axis controls production, and what free vs. total vs. bioavailable testosterone means for TRT dosing.