Can You Take Zetia and Crestor Together? Yes
Yes, ezetimibe and rosuvastatin are safe together with no significant interaction. Combo lowers LDL-C 50-65% without added myopathy risk.
Ezetimibe: Drug Interactions
25 source-based articles maintained by the HealthRX.com Editorial Team.
25articles
3topic areas covered
May 25, 2026latest review
Ezetimibe: Drug Interactions library
Showing 25 of 25 clinical reviews.
Ezetimibe (Zetia) and Clopidogrel Interaction: Safety, Mechanism, and Monitoring
Clinical review of the ezetimibe-clopidogrel drug interaction, covering metabolic pathways, severity classification, IMPROVE-IT trial context, monitoring guidance, and patient counseling.
Ezetimibe (Zetia) and PPIs (Omeprazole, Pantoprazole): Drug Interaction Guide
A source-checked review of whether ezetimibe (Zetia) interacts with proton pump inhibitors like omeprazole and pantoprazole, covering mechanism, FDA label information, and what remains unverified.
Ezetimibe (Zetia) and Trazodone: Drug Interaction Guide
Evidence-based review of the ezetimibe and trazodone combination, covering distinct metabolic pathways, pharmacodynamic overlap, monitoring, and what is and is not established about this pairing.
Ezetimibe and Rivaroxaban Interaction: Safety, Mechanism, and Monitoring
Can you take Zetia (ezetimibe) with rivaroxaban (Xarelto)? A guide covering pharmacokinetic mechanisms, CYP3A4/P-gp overlap, severity ratings, dose adjustments, and monitoring recommendations.
Zetia (Ezetimibe) and Diphenhydramine Interaction: What Clinicians and Patients Should Know
Is it safe to take Zetia (ezetimibe) with diphenhydramine? A guide covering pharmacokinetic mechanisms, severity rating, monitoring parameters, and patient counseling.
Zetia (Ezetimibe) and Gabapentin Interaction: Safety, Risks, and Monitoring
Can you take Zetia with gabapentin? Review the pharmacokinetic and pharmacodynamic interaction profile, clinical risk level, monitoring parameters, and dose-adjustment guidance for ezetimibe plus gabapentin.
Zetia (Ezetimibe) and NSAIDs (Ibuprofen, Naproxen): Drug Interaction Guide
Can you take Zetia with ibuprofen or naproxen? A guide to ezetimibe-NSAID interactions covering pharmacokinetics, liver monitoring, cardiovascular risk, and safe co-use protocols.
Zetia (Ezetimibe) and Prednisone Interaction: Safety, Risks, and Monitoring
Clinical guide to combining ezetimibe (Zetia) with prednisone. Covers pharmacokinetic and pharmacodynamic interactions, lipid effects of glucocorticoids, monitoring protocols, and dose-adjustment considerations.
Zetia and Acetaminophen Interaction: What You Need to Know
A clinical review of the ezetimibe-acetaminophen drug interaction, covering mechanism, hepatic risk, monitoring parameters, dose guidance, and patient counseling from HealthRX.com's medical team.
Zetia and Atorvastatin Together: Is It Safe?
Yes, ezetimibe and atorvastatin are safely combined; no dangerous interaction exists. FDA-approved combo cuts LDL up to 60%. See monitoring tips.
Zetia and Benzodiazepines Interaction: What Patients and Clinicians Need to Know
A guide to the ezetimibe (Zetia) and benzodiazepine interaction: mechanism, risk severity, monitoring, dose considerations, and patient counseling based on FDA labeling and primary literature.
Zetia and Bupropion Interaction: What Patients and Clinicians Need to Know
A guide to the ezetimibe, bupropion drug interaction, covering mechanism, clinical risk, monitoring parameters, dose considerations, and patient counseling points.
Zetia and Estradiol HRT Interaction: What Patients and Clinicians Need to Know
A comprehensive clinical guide to the ezetimibe and estradiol HRT interaction, covering mechanism, VTE and breast-cancer risk overlap, monitoring parameters, and patient counseling, prepared by the HealthRX.com Editorial Team.
Zetia and Finasteride Interaction: Can You Take Ezetimibe with a 5-Alpha Reductase Inhibitor?
Clinical guide to the ezetimibe (Zetia) and finasteride drug interaction. Covers CYP metabolism, shared pathways, monitoring, dose adjustment, and patient counseling backed by FDA labels and primary literature.
Zetia and Hormonal Contraceptives: Drug Interaction Guide
A cautious review of the ezetimibe (Zetia) and hormonal contraceptive interaction: what the FDA label supports, what is mechanistically plausible, and what remains unverified.
Zetia and Levothyroxine Interaction: What Patients and Clinicians Need to Know
A clinical guide to the ezetimibe-levothyroxine interaction: mechanism, evidence status, monitoring approach, and what remains unverified. Prepared for qualified medical review.
Zetia and Metformin Interaction: Safety, Mechanisms, and Monitoring
Can you take Zetia (ezetimibe) with metformin? A guide covering pharmacokinetic data, clinical evidence, monitoring protocols, and dose-adjustment considerations.
Zetia and Pregabalin Interaction: What Patients and Clinicians Need to Know
A detailed clinical review of the ezetimibe (Zetia) and pregabalin drug interaction, covering mechanism, severity, monitoring, dose adjustments, and patient counseling backed by primary literature.
Zetia and Progesterone HRT Interaction: What You Need to Know
A guide to the ezetimibe and progesterone HRT interaction, covering mechanism, severity, monitoring parameters, and patient counseling based on primary literature and FDA labeling.
Zetia and Sildenafil Interaction: What You Need to Know
Is it safe to take ezetimibe (Zetia) with sildenafil (Viagra)? A guide covering CYP metabolism, pharmacodynamic overlap, monitoring parameters, and dose-adjustment advice.
Zetia and Simvastatin Interaction: Safety, Dosing, and What to Monitor
Clinical guide to the ezetimibe-simvastatin drug interaction. Covers mechanism, dose limits, rhabdomyolysis risk, monitoring labs, and when combination therapy is appropriate.
Zetia and Tadalafil Interaction: What Patients and Clinicians Need to Know
A comprehensive guide to the ezetimibe, tadalafil drug interaction, covering mechanism, safety evidence, monitoring, and dosing guidance.
Zetia and Warfarin Interaction: Safety, Monitoring, and Clinical Evidence
Can you take Zetia (ezetimibe) with warfarin? A look at the pharmacokinetic interaction, INR monitoring, dose adjustment, and where the evidence is solid versus uncertain.
Zetia and Zolpidem Interaction: Safety, Risks, and Clinical Guidance
Can you take Zetia (ezetimibe) with zolpidem? A guide covering CYP metabolism, pharmacodynamic overlap, severity ratings, dose adjustments, and monitoring recommendations.