Modafinil Interactions: Full List and Risk Levels
Modafinil induces CYP3A4 and inhibits CYP2C19, lowering birth control and cyclosporine efficacy while raising levels of omeprazole, diazepam, and phenytoin.
Modafinil
5 source-based articles maintained by the HealthRX.com Editorial Team.
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4topic areas covered
May 26, 2026latest review
Modafinil library
Showing 5 of 5 clinical reviews.
Modafinil Safety Signals and FDA Actions: What Clinicians and Patients Should Know
A comprehensive review of modafinil (Provigil) safety signals, FDA regulatory actions, serious dermatologic reactions, psychiatric adverse events, and the rejected pediatric indication.
Modafinil Starting Dose for Adults (200 mg Guide)
Standard adult modafinil starting dose is 200 mg each morning, up to 400 mg max. See timing for narcolepsy, shift work, OSA, and liver dose adjustments.
Provigil How to Safely Stop: A Complete Modafinil Discontinuation Protocol
Learn how to safely stop modafinil (Provigil) with an evidence-based tapering protocol, withdrawal timeline, and clinical guidance from the HealthRX.com medical team.
Provigil Manufacturing, Supply & Shortage History: A Complete Timeline
A detailed history of modafinil (Provigil) manufacturing, FDA supply chain events, generic entry, and shortage timelines with clinical context and primary source citations.