Can I Take 5-HTP with Provigil (Modafinil)? A Clinical Review
A guide to the 5-HTP and Provigil (modafinil) interaction, covering serotonin syndrome risk, mechanisms, dose timing, and monitoring advice.
Supplements Modafinil
26 source-based articles maintained by the HealthRX.com Editorial Team.
26articles
3topic areas covered
Jan 28, 2025latest review
Supplements Modafinil library
Showing 26 of 26 clinical reviews.
Can I Take Alpha-Lipoic Acid with Provigil (Modafinil)?
Alpha-lipoic acid and Provigil (modafinil) have no documented direct drug interaction, but ALA's effects on blood sugar and thyroid hormone conversion warrant monitoring. Here's what the evidence says.
Can I Take Ashwagandha with Provigil (Modafinil)?
A guide to combining ashwagandha and modafinil (Provigil): what is known versus plausible about pharmacokinetic and pharmacodynamic interactions, cortisol, thyroid, and testosterone effects, and when to involve your prescriber.
Can I Take Berberine with Provigil (Modafinil)? Interaction Risk, Dosing, and Monitoring
Berberine inhibits CYP3A4, the same enzyme that clears modafinil. Learn the pharmacokinetic interaction risk, safe dose-separation windows, and monitoring steps if you take both.
Can I Take Caffeine with Provigil (Modafinil)? A Clinical Review
A guide covering the pharmacokinetic and pharmacodynamic interactions between caffeine and modafinil (Provigil), including dose guidance, blood pressure monitoring, and when to avoid the combination.
Can I Take Calcium with Provigil (Modafinil)?
A guide on whether calcium supplements are safe to take alongside Provigil (modafinil), covering pharmacokinetic interactions, dose timing, cardiovascular considerations, and monitoring recommendations.
Can I Take CoQ10 with Provigil (Modafinil)?
CoQ10 and Provigil (modafinil) have no known direct drug interaction, but timing, dose, and individual factors matter. A pharmacist-reviewed guide to combining them safely.
Can I Take Creatine with Provigil (Modafinil)? Safety, Interactions, and Monitoring
A guide covering whether creatine is safe to combine with modafinil (Provigil), the pharmacokinetic and pharmacodynamic interaction profile, creatinine lab concerns, and dosing guidance.
Can I Take Folate with Provigil (Modafinil)?
A guide to the folate-modafinil interaction: pharmacokinetics, MTHFR considerations, dosing windows, and monitoring recommendations for patients on Provigil.
Can I Take Ginseng with Provigil (Modafinil)? Interaction Risk, Mechanism, and Monitoring
Ginseng and Provigil (modafinil) have overlapping stimulant-like effects and a plausible but unconfirmed enzyme interaction. Here is what is established, what is theoretical, and what to verify with a prescriber or pharmacist before combining them.
Can I Take Glutathione With Provigil (Modafinil)?
A clinical breakdown of the modafinil-glutathione interaction: pharmacokinetics, liver metabolism, dosing strategy, and what the evidence actually shows.
Can I Take Glycine with Provigil (Modafinil)? Safety, Interactions, and Dosing
Evidence-based guide on combining glycine supplements with Provigil (modafinil). Covers pharmacokinetic and pharmacodynamic interactions, dose-separation timing, sleep effects, and monitoring recommendations.
Can I Take Green Tea Extract (EGCG) with Provigil (Modafinil)?
A guide to the safety, pharmacokinetic interactions, and monitoring recommendations for combining green tea extract or EGCG with modafinil (Provigil).
Can I Take L-Theanine with Provigil (Modafinil)?
A guide to combining L-theanine and Provigil (modafinil): pharmacokinetic data, pharmacodynamic interaction risks, safe dosing strategies, and when to call your prescriber.
Can I Take Lion's Mane with Provigil (Modafinil)?
Evidence-based guide on combining lion's mane mushroom with Provigil (modafinil). Covers pharmacokinetic and pharmacodynamic interactions, dose-separation strategies, monitoring, and clinical recommendations.
Can I Take Magnesium with Provigil (Modafinil)?
Evidence-based guide on taking magnesium supplements with Provigil (modafinil). Covers pharmacokinetic and pharmacodynamic interactions, dose-separation timing, monitoring, and clinical recommendations.
Can I Take Melatonin with Provigil (Modafinil)?
Evidence-based guide on combining melatonin with Provigil (modafinil): what is established about the interaction, what is plausible but unproven, dose-separation timing, and what to verify with a prescriber.
Can I Take N-Acetylcysteine (NAC) with Provigil (Modafinil)?
A guide to the NAC and modafinil combination: pharmacokinetic and pharmacodynamic interactions, dosing windows, monitoring, and when to ask your prescriber.
Can I Take Omega-3 (EPA/DHA) with Provigil (Modafinil)?
A guide covering the pharmacokinetic and pharmacodynamic interactions between omega-3 fatty acids (EPA/DHA) and modafinil (Provigil), including safety evidence, monitoring parameters, and practical guidance.
Can I Take Quercetin with Provigil (Modafinil)? A Clinical Review
Quercetin may inhibit CYP3A4 and histamine pathways that affect modafinil metabolism and wakefulness. Learn the pharmacokinetic interaction risk, practical dose-separation guidance, and what to discuss with your prescriber.
Can I Take Reishi Mushroom with Provigil (Modafinil)?
Reishi mushroom and Provigil (modafinil) have a theoretical interaction through CYP3A4 metabolism and antiplatelet effects. Learn what is established, what is plausible, and what remains unverified before combining them.
Can I Take Rhodiola with Provigil (Modafinil)? A Clinical Review
Detailed clinical review of combining rhodiola rosea with modafinil (Provigil): pharmacokinetic and pharmacodynamic interactions, safety evidence, dosing guidance, and monitoring recommendations.
Can I Take Turmeric / Curcumin with Provigil (Modafinil)?
A guide covering the pharmacokinetic and pharmacodynamic interactions between turmeric/curcumin and modafinil (Provigil), with dosing guidance, monitoring advice, and primary-source citations.
Can I Take Vitamin B12 with Provigil (Modafinil)?
Evidence-based guide on combining vitamin B12 supplements with Provigil (modafinil). Covers interaction risk, pharmacokinetics, dose timing, monitoring, and clinical recommendations.
Can I Take Vitamin D with Provigil (Modafinil)?
A guide to taking vitamin D with Provigil (modafinil). Learn the pharmacokinetic interaction risk, safe dosing windows, monitoring labs, and what the clinical evidence actually shows.
Can I Take Zinc with Provigil (Modafinil)? A Clinical Review
An evidence-based review of the zinc-modafinil combination: what is known about pharmacokinetic interaction, what is plausible but unproven, and what a clinician should verify before combining zinc with Provigil.