Can I Take 5-HTP with Provigil (Modafinil)? A Clinical Review
A physician-reviewed guide to the 5-HTP and Provigil (modafinil) interaction, covering serotonin syndrome risk, mechanisms, dose timing, and monitoring advice.
Supplements Modafinil
30 clinically reviewed articles, written and peer-reviewed by the HealthRX.com Medical Team.
30articles
3topic areas covered
Jan 28, 2025latest review
Supplements Modafinil library
Showing 30 of 30 clinical reviews.
Can I Take Alpha-Lipoic Acid with Provigil (Modafinil)?
Alpha-lipoic acid and Provigil (modafinil) have no documented direct drug interaction, but ALA's effects on blood sugar and thyroid hormone conversion warrant monitoring. Here's what the evidence says.
Can I Take Ashwagandha with Provigil (Modafinil)?
A physician-reviewed guide to combining ashwagandha and modafinil (Provigil): pharmacokinetic and pharmacodynamic interactions, cortisol, thyroid, and testosterone effects, dosing windows, and when to call your prescriber.
Can I Take Berberine with Provigil (Modafinil)? Interaction Risk, Dosing, and Monitoring
Berberine inhibits CYP3A4, the same enzyme that clears modafinil. Learn the pharmacokinetic interaction risk, safe dose-separation windows, and monitoring steps if you take both.
Can I Take Caffeine with Provigil (Modafinil)? A Clinical Review
A physician-reviewed guide covering the pharmacokinetic and pharmacodynamic interactions between caffeine and modafinil (Provigil), including dose guidance, blood pressure monitoring, and when to avoid the combination.
Can I Take Calcium with Provigil (Modafinil)?
A clinician-reviewed guide on whether calcium supplements are safe to take alongside Provigil (modafinil), covering pharmacokinetic interactions, dose timing, cardiovascular considerations, and monitoring recommendations.
Can I Take CoQ10 with Provigil (Modafinil)?
CoQ10 and Provigil (modafinil) have no known direct drug interaction, but timing, dose, and individual factors matter. A pharmacist-reviewed guide to combining them safely.
Can I Take Creatine with Provigil (Modafinil)? Safety, Interactions, and Monitoring
A physician-reviewed guide covering whether creatine is safe to combine with modafinil (Provigil), the pharmacokinetic and pharmacodynamic interaction profile, creatinine lab concerns, and dosing guidance.
Can I Take Folate with Provigil (Modafinil)?
A clinician-reviewed guide to the folate-modafinil interaction: pharmacokinetics, MTHFR considerations, dosing windows, and monitoring recommendations for patients on Provigil.
Can I Take Ginseng with Provigil (Modafinil)? Interaction Risk, Mechanism, and Monitoring
Ginseng and Provigil (modafinil) have overlapping stimulant effects and potential pharmacokinetic interactions via CYP enzymes. Learn the evidence on safety, dose separation, glucose monitoring, and anticoagulant risk.
Can I Take Glutathione With Provigil (Modafinil)?
A clinical breakdown of the modafinil-glutathione interaction: pharmacokinetics, liver metabolism, dosing strategy, and what the evidence actually shows.
Can I Take Glycine with Provigil (Modafinil)? Safety, Interactions, and Dosing
Evidence-based guide on combining glycine supplements with Provigil (modafinil). Covers pharmacokinetic and pharmacodynamic interactions, dose-separation timing, sleep effects, and monitoring recommendations.
Can I Take Green Tea Extract (EGCG) with Provigil (Modafinil)?
A physician-reviewed guide to the safety, pharmacokinetic interactions, and monitoring recommendations for combining green tea extract or EGCG with modafinil (Provigil).
Can I Take L-Theanine with Provigil (Modafinil)?
A clinician-reviewed guide to combining L-theanine and Provigil (modafinil): pharmacokinetic data, pharmacodynamic interaction risks, safe dosing strategies, and when to call your prescriber.
Can I Take Lion's Mane with Provigil (Modafinil)?
Evidence-based guide on combining lion's mane mushroom with Provigil (modafinil). Covers pharmacokinetic and pharmacodynamic interactions, dose-separation strategies, monitoring, and clinical recommendations.
Can I Take Magnesium with Provigil (Modafinil)?
Evidence-based guide on taking magnesium supplements with Provigil (modafinil). Covers pharmacokinetic and pharmacodynamic interactions, dose-separation timing, monitoring, and clinical recommendations.
Can I Take Melatonin with Provigil (Modafinil)?
Evidence-based guide on combining melatonin with Provigil (modafinil). Covers interaction mechanisms, dose-separation timing, safety data, and clinical monitoring recommendations.
Can I Take N-Acetylcysteine (NAC) with Provigil (Modafinil)?
A physician-reviewed guide to the NAC and modafinil combination: pharmacokinetic and pharmacodynamic interactions, dosing windows, monitoring, and when to ask your prescriber.
Can I Take Omega-3 (EPA/DHA) with Provigil (Modafinil)?
A clinician-reviewed guide covering the pharmacokinetic and pharmacodynamic interactions between omega-3 fatty acids (EPA/DHA) and modafinil (Provigil), including safety evidence, monitoring parameters, and practical dosing guidance.
Can I Take Quercetin with Provigil (Modafinil)? A Clinical Review
Quercetin may inhibit CYP3A4 and histamine pathways that affect modafinil metabolism and wakefulness. Learn the pharmacokinetic interaction risk, practical dose-separation guidance, and what to discuss with your prescriber.
Can I Take Reishi Mushroom with Provigil (Modafinil)?
Reishi mushroom and Provigil (modafinil) have a theoretical interaction through CYP3A4 metabolism and antiplatelet effects. Learn the evidence, monitoring steps, and dose-separation strategies.
Can I Take Resveratrol with Provigil (Modafinil)?
A clinical review of the resveratrol-modafinil interaction, covering CYP3A4 enzyme competition, estrogenic effects, dosing timing, and what to do if you are already taking both.
Can I Take Rhodiola with Provigil (Modafinil)? A Clinical Review
Detailed clinical review of combining rhodiola rosea with modafinil (Provigil): pharmacokinetic and pharmacodynamic interactions, safety evidence, dosing guidance, and monitoring recommendations.
Can I Take Saw Palmetto with Provigil (Modafinil)?
A clinical review of the saw palmetto and modafinil (Provigil) interaction: pharmacokinetics, CYP3A4 effects, bleeding risk, and how to take both safely.
Can I Take St. John's Wort with Provigil (Modafinil)?
St. John's Wort is a potent CYP3A4 inducer that can reduce modafinil blood levels and increase the risk of contraceptive failure. Learn the mechanism, clinical evidence, and what to do if you are already taking both.
Can I Take Turmeric / Curcumin with Provigil (Modafinil)?
A clinician-reviewed guide covering the pharmacokinetic and pharmacodynamic interactions between turmeric/curcumin and modafinil (Provigil), with dosing guidance, monitoring advice, and primary-source citations.
Can I Take Vitamin B12 with Provigil (Modafinil)?
Evidence-based guide on combining vitamin B12 supplements with Provigil (modafinil). Covers interaction risk, pharmacokinetics, dose timing, monitoring, and clinical recommendations.
Can I Take Vitamin B6 with Provigil (Modafinil)?
A clinician-reviewed guide covering the pharmacokinetic and pharmacodynamic interactions between vitamin B6 (pyridoxine) and Provigil (modafinil), including safe dose ranges, monitoring advice, and when to call your prescriber.
Can I Take Vitamin D with Provigil (Modafinil)?
A physician-reviewed guide to taking vitamin D with Provigil (modafinil). Learn the pharmacokinetic interaction risk, safe dosing windows, monitoring labs, and what the clinical evidence actually shows.
Can I Take Zinc with Provigil (Modafinil)? A Clinical Review
A board-reviewed guide covering the zinc-modafinil interaction: pharmacokinetics, thyroid hormone effects, copper balance, dosing windows, and monitoring recommendations for safe concurrent use.