48 source-based articles maintained by the HealthRX.com Editorial Team.
Showing 48 of 48 clinical reviews.
A guide to Humana's Viagra and sildenafil coverage policies, prior authorization criteria, formulary tiers, step therapy requirements, and how to appeal a denial in 2024 to 2025.
A complete guide to TRICARE coverage for Viagra (sildenafil): formulary status, prior authorization criteria, step therapy requirements, denial appeals, and cost-saving alternatives for military beneficiaries.
Sildenafil is used in children under 12 only for pulmonary arterial hypertension, not erectile dysfunction. What is established about FDA warnings, weight-based dosing, and monitoring, and what still needs verification against primary trial data.
A comprehensive clinical guide to sildenafil monitoring in children under 12, covering FDA-approved indications, weight-based dosing, hemodynamic surveillance, growth tracking, and off-label use evidence.
Evidence-based guide to sildenafil safety in children under 12, covering FDA warnings, the STARTS trial program, weight-based dosing for pulmonary arterial hypertension, and monitoring requirements.
Evidence-based protocols for switching between sildenafil (Viagra) and other PDE5 inhibitors including tadalafil, vardenafil, and avanafil. Covers dose equivalence, washout timing, and clinical decision points.
There is no FDA-approved sildenafil (Viagra) dosing for erectile dysfunction in adolescents aged 12-17. Learn why, what the pediatric data actually covers, and when specialist referral is appropriate.
A deep dive into sildenafil's effects on skeletal muscle, exercise capacity, and emerging preservation strategies. Covers PDE5 inhibition, blood flow, mitochondrial signaling, clinical trials, and practical dosing context.
A deep dive into sildenafil's effects on renal hemodynamics, diabetic nephropathy, AKI risk, and drug interactions, with primary-literature citations throughout.
A clinician-grade guide to every major sildenafil drug interaction, including nitrates, alpha-blockers, CYP3A4 inhibitors, and riociguat, with dosing adjustments and cited evidence.
Complete sildenafil dosing guide for adults aged 30 to 49, covering standard doses, timing, dose titration, drug interactions, and clinical trial evidence for erectile dysfunction treatment.
A guide to sildenafil dosing for men aged 18 to 29, covering starting doses, titration, timing, drug interactions, and when ED in young men warrants further workup.
A GRADE-graded breakdown of sildenafil's clinical evidence for erectile dysfunction, covering landmark trials, effect sizes, guideline recommendations, and practical dosing.
A complete clinical guide to monitoring sildenafil (Viagra) in patients aged 65 and older, covering dose adjustments, drug interactions, cardiovascular checks, fall risk, and when to deprescribe.
A clinician-grade review of sildenafil off-label uses beyond erectile dysfunction, including Raynaud's, altitude sickness, heart failure, and antidepressant-induced sexual dysfunction, with evidence levels and trial data.
A clinical review of real-world evidence for sildenafil (Viagra) from patient registries, observational cohorts, post-marketing surveillance, and large-database studies beyond the original RCTs.
A guide to sildenafil (Viagra) safety in adults aged 30 to 49, covering cardiovascular risks, drug interactions, side effects, contraindications, and monitoring recommendations.
Evidence-based safety profile of sildenafil (Viagra) in adults aged 50 to 64, covering cardiovascular risk, drug interactions, dosing adjustments, and monitoring recommendations.
A clinically detailed guide to sildenafil safety in men aged 18 to 29, covering evidence-based dosing, contraindications, cardiovascular risks, fertility effects, and when to seek care.
Evidence-based guide to sildenafil (Viagra) safety in geriatric patients, covering dose adjustments, drug interactions, cardiovascular screening, falls risk, and deprescribing considerations for men 65+.
A guide on how to safely stop sildenafil (Viagra), covering the drug's mechanism, why it does not cause physical dependence, and when to taper or discontinue under medical supervision.
A look at whether sildenafil (Viagra) affects appetite, hunger, or food cravings, covering the pharmacology, trial data, patient reports, and what to do if you notice changes.
An evidence-based guide to sildenafil (Viagra) use during pregnancy and breastfeeding, covering mechanism, fetal risk, breast milk transfer, and current clinical guidance.
A clinician-level review of sildenafil (Viagra) use in autoimmune and inflammatory conditions, covering pharmacology, drug interactions, disease-specific guidance, and safety data from primary literature.
A deep dive into sildenafil's effects on bone mineral density, osteoblast signaling via PDE5 inhibition, and what the clinical evidence means for patients on long-term Viagra therapy.
A deep dive into sildenafil's effects on cognition, cerebral blood flow, dementia risk, and brain health. Covers PDE5 inhibition mechanisms, clinical trial data, and practical prescribing considerations.
A analysis of every major epidemiological signal linking sildenafil (Viagra) to cancer risk, including melanoma, prostate cancer, and the proposed PDE5 mechanism. Includes trial data, FDA communications, and a clinical decision framework.
A clinical deep-dive into sildenafil's long-term cardiovascular effects, covering PDE5 inhibitor mechanisms, mortality data, drug interactions, and who should avoid use. prepared by the HealthRX.com Editorial Team.
A comparison of sildenafil (Viagra) pricing against tadalafil, vardenafil, and avanafil, with a boundary map of what the evidence does and does not support and a decision framework for choosing between them.
How to dose sildenafil (Viagra) safely in patients with hepatic impairment. Covers pharmacokinetics, Child-Pugh adjustments, cirrhosis data, and clinical monitoring.
How to dose sildenafil (Viagra) safely in patients with kidney disease. Covers mild, moderate, and severe renal impairment, dialysis considerations, and FDA label guidance backed by pharmacokinetic data.
A clinical review of sildenafil's next-generation formulations, novel PDE5 inhibitor pipeline candidates, and emerging delivery technologies beyond the traditional oral tablet.
A clinical deep-dive into the documented hair and skin effects of sildenafil (Viagra), including flushing, rashes, alopecia signals, and what the primary literature actually says.
The complete history of Viagra (sildenafil), from its origins as a failed angina drug to FDA approval in 1998 and beyond. Mechanism of action, key clinical trials, patent expiry, and ongoing research.
A clinician-level review of how sildenafil (Viagra) is metabolized by the liver, what hepatic impairment means for dosing, and which lab changes to monitor.
A clinical review of sildenafil (Viagra) manufacturing origins, global supply chain evolution, FDA shortage records, and current generic availability for erectile dysfunction treatment.
Clinical guide to sildenafil (Viagra) overdose: symptoms, emergency treatment, nitrate co-ingestion dangers, priapism management, and prevention of accidental excess dosing.
What is and isn't established about genetic variation in CYP2C9, CYP3A4, PDE5A, NOS3, and GUCY1A3 and how it may relate to sildenafil (Viagra) efficacy and side effects, with a practical decision framework for when genetic testing is worth pursuing.
An MD-level breakdown of sildenafil (Viagra) pharmacokinetics covering absorption, distribution, metabolism, and excretion, with primary PubMed and FDA citations throughout.
A guide to the sildenafil pre-surgery hold window: why anesthesiologists require it, exactly how long to stop Viagra before an operation, and what happens if the drug is still on board during general or neuraxial anesthesia.
A clinician-grade overview of sildenafil (Viagra) regulatory status across the United States, European Union, Canada, and United Kingdom, including OTC reclassification, generic availability, and prescribing frameworks.
A comprehensive guide to sildenafil (Viagra) safety signals, FDA regulatory actions, post-market surveillance findings, drug interactions, and clinical risk stratification, with primary-source citations throughout.
Sildenafil (Viagra) is taken by mouth, not by injection. Learn how sildenafil works, when intracavernosal injection (ICI) therapy becomes the next step, and the correct self-injection technique for alprostadil and trimix.
An evidence-based breakdown of how sildenafil (Viagra) affects sexual function, covering mechanism, efficacy data from landmark trials, dosing, safety, and who responds best.
A clinician-level review of how sildenafil (Viagra) affects REM sleep, slow-wave sleep, nocturnal penile tumescence, and overnight oxygen saturation, with primary-literature citations and dosing guidance.
A guide to sildenafil (Viagra) storage conditions, shelf-life data, chemical stability research, and what happens when tablets degrade. Includes PubMed-cited evidence and FDA guidance.
How to time sildenafil (Viagra) doses when crossing time zones, managing jet lag, altitude, and travel-related factors that affect PDE5 inhibitor pharmacokinetics. protocols with primary-source citations.
A clinician-level review of how sildenafil (Viagra) affects mood, anxiety, depression, and psychological well-being in men with erectile dysfunction, with primary-literature citations throughout.
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