A retinoid blend with vitamin C.
Tretinoin 0.05%, niacinamide 5% and vitamin C 5% in one cream. Explore retinoid signaling and the supporting vitamin ingredients before comparing formulas.
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Meet the formula
The three names in this cream represent different ingredient families. Tretinoin supplies the retinoid component, niacinamide supplies a topical form of vitamin B3, and vitamin C supplies an antioxidant ingredient. Together they define a specific blend: tretinoin 0.05%, niacinamide 5% and vitamin C 5%. Understanding each role makes the product more informative than a general “renewal” description and gives you a clear basis for comparing it with tretinoin alone or another combination cream.
Tretinoin and retinoic-acid receptors
Niacinamide and skin-appearance research
Antioxidant and collagen-biology context
Inside the formula
0.05%
Tretinoin is retinoic acid, a vitamin A derivative that acts through retinoic-acid receptors. It is the retinoid at the center of this blend. Research on topical tretinoin includes acne and photoaged skin. Its ingredient identity distinguishes this cream from a BHA-based exfoliating product and from a hormone-containing estriol formula.
5%
Niacinamide is a form of vitamin B3 used in topical skincare. Clinical research has examined measures including visible texture and pigmentation. It supplies a supporting vitamin ingredient alongside tretinoin in this formula. The listed 5% describes its own component, rather than changing the meaning of the tretinoin concentration.
5%
Vitamin C is known for antioxidant activity and its role in collagen biosynthesis. Studies of topical vitamin C have evaluated particular formulations on photoaged skin. Its inclusion distinguishes this blend from a tretinoin-only product and gives it another ingredient family to consider when reviewing the actives already in a routine.
A closer look / 01
Both sit within the broader vitamin A skincare conversation. Tretinoin is retinoic acid itself; retinol is a different vitamin A form. That distinction is part of why the ingredient name matters as much as the percentage on a product. A retinol serum and a tretinoin cream are different formulations, rather than the same active at two strengths.
The same principle applies to supporting ingredients. Niacinamide and vitamin C do not become retinoids because they are formulated with tretinoin. Reading the blend ingredient by ingredient makes it easier to recognize the central active and the separate supporting components.
A closer look / 02
This listing brings all three named actives into one cream. Buying separate tretinoin, niacinamide and vitamin C products creates a different routine with separate vehicles and strengths. The combined cream therefore has a practical product identity as well as an ingredient identity: one topical formulation, with its specified active list.
When comparing alternatives, write down the active ingredients already present in your treatment products and serums. That shows whether a blend would share ingredients with the current routine. Comparing the full list is more useful than assuming an additional bottle is needed for every ingredient mentioned on the page.
A closer look / 03
Visible fine lines, surface roughness and uneven pigmentation are different observations. Tretinoin studies and vitamin-ingredient studies have measured specific aspects of skin rather than one universal renewal score. A vehicle-controlled study, for example, compares an active cream with its base to ask what the active contributes. That distinction helps you read ingredient evidence more clearly.
For your own record, keep lighting consistent and note visible texture separately from color and the feel of hydration. The cream’s application experience is another observation. A clear record can capture all of them without treating one good or bad skin day as a complete assessment.
Make an informed comparison
The central question is which active list you are comparing. This cream contains three named actives. Tretinoin-only and tretinoin-niacinamide products have their own specified formulations, while the estriol blend uses a different central ingredient family.
| Option | Ingredient identity | What distinguishes it |
|---|---|---|
| This blend | Tretinoin 0.05% / niacinamide 5% / vitamin C 5% | Retinoid with two vitamin ingredients |
| Tretinoin | Tretinoin | Focused retinoid formulation |
| Estriol / Vitamin C / Hyaluronic Acid | Estriol / vitamin C / hydrolyzed hyaluronic acid | Estrogen, antioxidant and humectant components |
The useful details
Each percentage belongs to a different molecule. The tretinoin concentration describes tretinoin; the niacinamide and vitamin C concentrations describe their respective components. Adding them would discard the ingredient information that makes this formulation understandable.
Hydroquinone and kojic-acid formulas place pigment-focused ingredients at the center. This formula places a retinoid at the center, with niacinamide and vitamin C alongside it. A shared skincare goal or shared niacinamide ingredient can coexist with a different complete formula.
Explore the ingredient research
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A defined retinoid concentration in the verified formulation.
The same vitamin B3 concentration evaluated in a 12-week skin-appearance trial.
The third ingredient in this blend, replacing the hyaluronic acid found in another option.
Three named ingredients and concentrations, shown together before you choose a plan.
This formula pairs tretinoin with niacinamide and vitamin C in one topical blend. Tretinoin is the retinoid component, niacinamide is vitamin B3, and vitamin C adds a different third ingredient from the hyaluronic acid in the existing tretinoin and niacinamide cream.
Tretinoin
The retinoid component in the topical formula.
Niacinamide
Vitamin B3 is paired with the retinoid.
Vitamin C
Completes this three-ingredient formulation.
Niacinamide and vitamin C have been evaluated in separate skin-appearance trials. The references below cover those studied formulations.
50 participants
A separate study evaluated 5% niacinamide over 12 weeks.
Bissett et al., 2005
6 months
A separate vitamin C cream trial followed photoaged skin over six months.
Humbert et al., 2003
Compare the ingredients and format before choosing your plan.
| Tretinoin + Niacinamide + Vitamin C | Tretinoin + Niacinamide | |
|---|---|---|
| Formula | Tretinoin / niacinamide / vitamin C | Tretinoin / niacinamide / hyaluronic acid |
| Format | Topical cream | Topical cream |
| Ordering | Online plan selection | Online plan selection |
The steps from choosing your plan to continuing your routine.
Getting started
Compare the ingredients and the available purchase options.
After checkout
Use the instructions provided with your prescribed formulation.
Along the way
Contact the existing care team with questions about your treatment or order.
HealthRX.com verified facts
Tretinoin / Niacinamide / Vitamin C starts at $150 per month on monthly plan; the lowest checkout charge is $150 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified October 3, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
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Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.
