Skin
Vitamin C appears in several topical combinations, including tretinoin and estriol products. The atlas searches both vitamin C and ascorbic acid, so the material named in each paper matters.
The estriol combination lists vitamin C 5%, and the tretinoin-niacinamide-vitamin C product also lists 5%. Sharing a percentage does not make their complete formulations the same: the companion ingredients differ.
A study may specify a particular vitamin C form, vehicle and storage conditions. Those details help connect an ingredient result to a topical formulation without assuming that every vitamin C preparation behaves alike.
| Product | Listed formulation | Connected ingredient research |
|---|---|---|
| Hydroquinone 8% Cream | Hydroquinone 8% / Tretinoin / Vitamin C / Niacinamide | Hydroquinone · Tretinoin · Vitamin C · Niacinamide |
| Estriol / Vitamin C / Hyaluronic Acid | estriol 0.3%, vitamin C 5% and hydrolyzed hyaluronic acid 0.5% | Estriol · Vitamin C · Hyaluronic acid |
| Tretinoin / Niacinamide / Vitamin C | tretinoin 0.05%, niacinamide 5% and vitamin C 5% | Tretinoin · Niacinamide · Vitamin C |
Publication history
The chart counts records mentioning the search terms in their title or abstract. It includes research beyond skin. Use the period controls to inspect the count.
2026: 2,239 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.
| Period | Publications |
|---|---|
| 1900-1959 | 3230 |
| 1960-1969 | 2010 |
| 1970-1979 | 2795 |
| 1980-1989 | 4329 |
| 1990-1999 | 6789 |
| 2000-2009 | 11952 |
| 2010-2014 | 8110 |
| 2015-2019 | 9202 |
| 2020 | 2445 |
| 2021 | 2598 |
| 2022 | 2771 |
| 2023 | 2772 |
| 2024 | 2969 |
| 2025 | 3062 |
| 2026 | 2239 |
Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.
TITLE_ABS:(("ascorbic acid" OR "vitamin C")) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]
The focused search returns 358 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.
TITLE_ABS:(("ascorbic acid" OR "vitamin C")) AND TITLE_ABS:((topical AND skin)) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]
Dated publications
The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.
Review · Journal Article
Badash A, Garibay A, Petronic-Rosic V. Clinics in dermatology. PMID 41690651.
This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.
Read the PubMed record · Publisher recordWhich chemical form and vehicle were studied? Was vitamin C tested alone or as part of the same combination?
Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.