- LegitScript Certified
- US-licensed pharmacy
- Ships in 3 to 5 days
- Concentration
- Rapamycin (Sirolimus) 1 mg
- Purity
- Provider reviewed
- Unit
- 24 capsules
- Category
- Longevity
Common questions
What is rapamycin?
What is rapamycin used for?
What does rapamycin do?
Rapamycin (Sirolimus)
The longevity molecule, prescribed.
Rapamycin (sirolimus) · 1 mg
- Targets mTOR
- Weekly, not daily
- Provider-set dose
- Studied in aging research
What's Included
- ✓Medication and supplies
- ✓Provider visit and unlimited follow-ups
- ✓Free expedited shipping
Pause, change, or cancel anytime from your account.
How Would You Like To Pay?
Choose Your Plan
1-Month Plan
$152- $152 Billed Today
- Then $152 Every Month
- Cancel Anytime
Or pay with
$152 billed today, then every month until canceled.
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Your provider confirms the strength and dose after intake. Payment does not guarantee a prescription.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your rapamycin ships.
HealthRX.com verified facts
Rapamycin (Sirolimus) online: price and access
Rapamycin (Sirolimus) starts at $122 per month on 12-month plan; the lowest checkout charge is $152 (billed monthly). A prescription is never guaranteed. A licensed provider reviews each request before a pharmacy can dispense treatment.
Catalog verified August 26, 2026. Source: HealthRX.com checkout catalog and refund policy. Monthly equivalent divides the discounted plan charge by the number of months; checkout may collect a multi-month total.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A US-licensed provider reviews your history and, if appropriate, prescribes a weekly protocol off-label.
Ships to your door
Your dose is compounded and ships to your door in 3 to 5 days.
Ongoing support
Your provider checks lipids and blood counts and adjusts the protocol.
Targets the mTOR pathway
Rapamycin inhibits mTOR, a central regulator of how your cells balance growth and repair.
A weekly protocol
Longevity dosing is low and intermittent, usually once a week, set by your provider rather than taken daily.
At the center of aging research
Rapamycin is the most studied molecule in the field, though most of that evidence is from laboratory models and human longevity trials are still early.
Provider-set and monitored
A US-licensed provider prescribes it off-label and monitors labs such as lipids and blood counts.
About Rapamycin (Sirolimus)
Rapamycin is the molecule at the center of longevity research, because it inhibits mTOR, a pathway that governs how cells balance growth and repair. It is prescribed off-label, typically on a weekly protocol your provider sets. Reviewed by a licensed provider, compounded by a US-licensed pharmacy.
- Inhibits the mTOR longevity pathway
- Weekly protocol set by your provider
- The most-studied molecule in the space
- Provider-reviewed, real pricing up front
Rapamycin (sirolimus) inhibits the mTOR pathway, which regulates cell growth, metabolism and autophagy. Compounded by a US-licensed pharmacy.
Binds FKBP12
Rapamycin pairs with a protein called FKBP12 inside your cells.
Inhibits mTORC1
That pairing blocks mTORC1, a hub that drives cell growth.
Shifts toward repair
With growth signaling turned down, cells lean toward maintenance and autophagy, their cleanup process.
In laboratory studies this shifts cells from growth toward repair. Whether that translates to longevity in people is still being studied.
Weekly longevity protocol or Daily transplant dosing
Why longevity dosing looks different from transplant dosing
| Weekly longevity protocol | Daily transplant dosing | |
|---|---|---|
| Dose size | Low | High |
| How often | Usually once a week | Every day |
| Immune suppression | Kept low by the dose | Strong, intended |
| Goal | Dial down mTOR intermittently | Prevent organ rejection |
| Monitoring | Periodic labs | Intensive drug-level monitoring |
| Prescribed | Off-label, provider-set | On-label immunosuppression |
What to expect
This is a long-horizon protocol rather than something you feel day to day. Your provider sets the cadence and monitors you over time.
Week 1
Start your protocol
Begin the weekly dose your provider sets.
Week 2 to 4
Watch tolerance
Note any mouth sores or stomach changes and message your provider.
Week 6 to 8
Check labs
Your provider reviews your lipids and blood counts.
Ongoing
Adjust the dose
Your provider tunes the protocol to how you respond.
Safety and side effects
Prescribed off-label and not right for everyone. Rapamycin is an immunosuppressant, so it can raise infection risk; avoid live vaccines while on it. It interacts with grapefruit and CYP3A4 medications, which change its levels. Tell your provider about infections and every medication.
Common
- Mouth sores or canker sores
- Higher cholesterol or triglycerides
- Mild nausea or diarrhea
- Acne-like skin bumps
Less common
- Slower wound healing
- Mild swelling in the legs or ankles
- Changes in blood counts
Seek care
- Higher risk of infection from immune modulation
- Lung inflammation, a rare but serious reaction that needs prompt care
Rapamycin interacts with grapefruit and many medicines through the CYP3A4 pathway, so share your full medication list. Your provider monitors lipids and blood counts, and the protocol is paused around surgery or active infection. Live vaccines are avoided while taking it.
Frequently asked questions
Is sirolimus the same as rapamycin?
Other longevity options
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.