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Hyaluronic acid: the research history.

Hyaluronic acid appears in a tretinoin-niacinamide blend and in the estriol-vitamin C blend. The latter specifies hydrolyzed hyaluronic acid, which adds another formulation detail.

33,045records matching the ingredient search
2connected formulations
8displayed publication records

How the research connects to the formula

The literature search covers hyaluronic acid across many applications. A publication about a different route, material preparation or tissue does not automatically describe these topical creams.

The useful connection is between the exact ingredient form in a study and the exact formulation in the catalog. Hydrolyzed material, molecular weight, vehicle and concentration can be recorded as separate fields when the source reports them.

Current HealthRX.com formulation map
ProductListed formulationConnected ingredient research
Tretinoin + Niacinamide CreamTretinoin + Niacinamide 4% + Hyaluronic AcidTretinoin · Niacinamide · Hyaluronic acid
Estriol / Vitamin C / Hyaluronic Acidestriol 0.3%, vitamin C 5% and hydrolyzed hyaluronic acid 0.5%Estriol · Vitamin C · Hyaluronic acid

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond skin. Use the period controls to inspect the count.

2026: 2,383 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table
PeriodPublications
1900-1959286
1960-1969241
1970-1979657
1980-19891552
1990-19991906
2000-20093458
2010-20143559
2015-20195924
20201663
20211878
20221977
20232024
20242527
20253010
20262383
Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:("hyaluronic acid") AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 474 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:("hyaluronic acid") AND TITLE_ABS:((topical AND skin)) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Journal Article

Hexagram prism structure composed of hyaluronic acid and hydrolyzed collagen as a dissolvable physical micro-disruption platform for topical delivery of hydrophilic cargos.

Kim JS, Cho Y, Park B, Kim HW, Park Y, Seon-Woo HS, Rim SY, Jeong DI, Lee SY, Hwang C, Lee H, Jun H, Baek SK, Cho HJ. International journal of biological macromolecules. PMID 42586339.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Does the source identify the hyaluronic-acid preparation? Was the outcome a hydration measure, a visible skin measure or an outcome in another tissue?

Source records

Hexagram prism structure composed of hyaluronic acid and hydrolyzed collagen as a dissolvable physical micro-disruption platform for topical delivery of hydrophilic cargos.Kim JS, Cho Y, Park B, Kim HW, Park Y, Seon-Woo HS, Rim SY, Jeong DI, Lee SY, Hwang C, Lee H, Jun H, Baek SK, Cho HJ.International journal of biological macromolecules. 2026-08-12. PMID 42586339. Journal Article.
EVIDENCE-BASED REVIEW & RECOMMENDATIONS FROM THE BRAZILIAN SOCIETY OF SHOULDER AND ELBOW SURGERY: HYALURONIC ACID VERSUS CORTICOSTEROID INJECTIONS FOR SHOULDER OSTEOARTHRITIS.Lara PHS, Belangero PS, Schiefer M, Zanesco L, Fernandes MR, Murachovsky J, de Medeiros JF, Malavolta EA.Acta ortopedica brasileira. 2026-08-31. PMID 42683154. review-article, Review, Journal Article.
EVIDENCE-BASED REVIEWS & RECOMMENDATIONS FROM THE BRAZILIAN SOCIETY OF SHOULDER AND ELBOW SURGERY: HYALURONIC ACID INFILTRATION FOR ELBOW EPICONDYLITIS IN ADULTS.Pinto GMR, Zanesco L, Amaral MVG, Matsunaga FT, Bonadiman JA, de Medeiros JF, Campos MCO, Malavolta EA.Acta ortopedica brasileira. 2026-08-31. PMID 42683236. review-article, Review, Journal Article.
EVIDENCE-BASED REVIEWS & RECOMMENDATIONS FROM THE BRAZILIAN SOCIETY OF SHOULDER AND ELBOW SURGERY: HYALURONIC ACID INJECTION VERSUS PHYSIOTHERAPY FOR ROTATOR CUFF TENDINOPATHY IN ADULTS.Fernandes MR, Zanesco L, Murachovsky J, Mouraria GG, Lara PHS, Belangero PS, de Medeiros JF, Malavolta EA.Acta ortopedica brasileira. 2026-08-31. PMID 42683435. review-article, Review, Journal Article.
Microneedling Combined With Topical Poly-L-Lactic Acid and Hyaluronic Acid for Skin Elasticity and Hydration: A Pilot Comparative Study. Arutinova V, Nishnianidze N, Tsintsadze M, Kadzhaya A, Sulamanidze G.Cureus. 2026-09-04. PMID 42830871. Journal Article.
A Hyaluronic Acid-Coated Ethosomal Delivery System for Improving the Topical Delivery of Glycyrrhetinic Acid in Sensitive Skin.Wang Y, Ren S, Deng J, Luo D, Liu R, Zhou Y, Chen S, Liu W.Pharmaceutics. 2026-09-04. PMID 42797289. research-article, Journal Article.
Engineering lymphatic collecting vessel phenotypes through combined hyaluronic acid cues and oscillatory shear stress.Lightsey NK, Fluskey G, Cruz-Gonzalez B, Fan F, Saha S, Hall E, Hanjaya-Putra D.Cell reports methods. 2026-09-04. PMID 42697195. Journal Article.
Clinical outcomes of hyaluronic acid-sorbitol injection in athletes with patellofemoral pain: Evaluation of the potential influence of body mass index.Vélez de Lachica JC, Serrano S, Vidovic E, Farfan A.PloS one. 2026-09-30. PMID 42814735. Clinical Trial, research-article, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.