Skin

Estriol: the research history.

Estriol appears in a topical combination with vitamin C and hydrolyzed hyaluronic acid. The 0.3% estriol concentration creates a specific connection to historical topical-estrogen research.

4,654records matching the ingredient search

1connected formulations

6displayed publication records

How the research connects to the formula

The displayed 1996 study compared 0.3% estriol and 0.01% estradiol preparations in fifty-nine women over six months. It measured skin-related outcomes. That source should be described with its own design and population rather than as a trial of the complete HealthRX.com blend.

The catalog adds vitamin C 5% and hydrolyzed hyaluronic acid 0.5%. Those ingredients make the formula distinct from the historical estriol preparation even though the estriol percentage matches.

Current HealthRX.com formulation map
Product	Listed formulation	Connected ingredient research
Estriol / Vitamin C / Hyaluronic Acid	estriol 0.3%, vitamin C 5% and hydrolyzed hyaluronic acid 0.5%	Estriol · Vitamin C · Hyaluronic acid

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond skin. Use the period controls to inspect the count.

2026: 44 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table

Period	Publications
1900-1959	50
1960-1969	353
1970-1979	809
1980-1989	841
1990-1999	585
2000-2009	675
2010-2014	419
2015-2019	396
2020	82
2021	70
2022	89
2023	90
2024	70
2025	81
2026	44

Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(estriol) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Controlled Clinical Trial · Comparative Study · Clinical Trial · Journal Article

Treatment of skin aging with topical estrogens.

Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. International journal of dermatology. PMID 8876303.

Study design: Comparative topical-estrogen study, 59 women
What was tested: Estriol 0.3% and estradiol 0.01% preparations over six months, with skin measurements and a biopsy subset.
What was reported: The investigators reported changes in skin-related measurements in both active-treatment groups.
How it connects to the catalog: The 0.3% estriol concentration matches one catalog field, while the full HealthRX.com product also contains vitamin C and hydrolyzed hyaluronic acid. The source does not test that complete blend.

Read the PubMed record · Publisher record

Study comparison

Publication	Design and regimen	Reported finding	Interpretation
1996-09-01: Treatment of skin aging with topical estrogens.	Comparative topical-estrogen study, 59 women. Estriol 0.3% and estradiol 0.01% preparations over six months, with skin measurements and a biopsy subset.	The investigators reported changes in skin-related measurements in both active-treatment groups.	The 0.3% estriol concentration matches one catalog field, while the full HealthRX.com product also contains vitamin C and hydrolyzed hyaluronic acid. The source does not test that complete blend.

Questions that shape the comparison

Did the source compare estriol with a vehicle control or another active treatment? Were the other two catalog ingredients present?

Source records

Treatment of skin aging with topical estrogens.Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A.International journal of dermatology. 1996-09-01. PMID 8876303. Controlled Clinical Trial, Comparative Study, Clinical Trial, Journal Article.

Effects of Erbium:YAG laser combined with vaginal estriol therapy in postmenopausal women with Genitourinary Syndrome of Menopause: protocol for a randomised, double-blind, controlled trial.Souza MCDCD, de Jármy-Di Bella ZIK, Bianchi-Ferraro AMHM, Souza SDL, Amanda Rafaelly Honório M, Sobral APT, Ribeiro CDPV, Bussadori SK, Fernandes KPS, Chavantes MC, Zamuner SR.BMJ open. 2026-06-11. PMID 42276807. Clinical Trial Protocol, research-article, Journal Article.

Effect of topical vaginal estrogen after radiotherapy for cervical cancer: a randomized, double-blind pilot trial.Ramalho NM, Lima Sales JTO, Carneiro VCG, Batista TP, Souza GFA, Andreatta ACF, Cantilino CT, Martins MRR, Santos VTA, Lima Vidal ME, da Fonte ALF, Santos CAAL, de Azevedo CRAS.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2026-06-26. PMID 42468465. Randomized Controlled Trial, Journal Article.

Correction to: Estriol attenuates visceral adiposity and pulmonary artery smooth muscle cell proliferation via ERα-mediated signalling.European heart journal open. 2026-07-01. PMID 42577853. Published Erratum, correction.

Intravaginal radiofrequency versus local estrogen and prasterone for genitourinary syndrome of menopause: a comparative study of clinical outcomes.Llaneza IP, Parugues BD, de la Noval BD, Aldecoa Álvarez MB, Doblas PV, Chiminazzo V, Llaneza Coto ÁP.European journal of obstetrics, gynecology, and reproductive biology. 2026-08-22. PMID 42648084. Journal Article.

Targeting hormone treatment for the brain in menopause.Itoh N, Itoh Y, Patil R, Till C, Smith M, Schwartz J, Davis B, Oberman E, Romeroso BD, Voskuhl RR.Scientific reports. 2026-09-01. PMID 42680785. research-article, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.