Losartan + Spironolactone: Hyperkalemia Risk Pharmacists Watch
Combining losartan with spironolactone raises hyperkalemia risk via dual RAAS blockade; pharmacists should monitor serum potassium and renal function closely.
Losartan
10 source-based articles maintained by the HealthRX.com Editorial Team.
10articles
5topic areas covered
Jul 14, 2025latest review
Losartan library
Showing 10 of 10 clinical reviews.
Losartan Dosing in Renal Impairment: Evidence-Based Guidelines for Kidney Disease
Losartan dosing in kidney disease, creatinine and potassium follow-up, and what RENAAL and STOP-ACEi show about continuing treatment as eGFR falls.
Losartan Geriatric (65+) Dosing: Evidence-Based Guide
Losartan dosing after age 65: when 25 or 50 mg is used, kidney and potassium monitoring, trial results, dose timing and supervised medication reduction.
Losartan Geriatric (65+) Monitoring: Lab Schedules, Dose Adjustments, and Safety Checks
Evidence-based monitoring guide for losartan in adults 65 and older, covering renal function, potassium, blood pressure targets, fall risk, and drug interactions.
Losartan Hair and Skin Changes: What Patients and Clinicians Need to Know
A clinical deep-dive into losartan's documented effects on hair and skin, including alopecia, psoriasiform reactions, and rare dermatologic adverse events, with primary-literature citations and prescriber guidance.
Losartan Overdose and Accidental Excess Dose: Recognition, Treatment, and Clinical Management
Losartan extra-dose and overdose evidence: symptoms, actual poison-center findings, charcoal and dialysis limits, and exposure-specific assessment.
Losartan Safety in Older Adults (65+): Geriatric Dosing, Risks, and Monitoring
Evidence-based guide to losartan safety in adults 65 and older, covering renal monitoring, fall risk, hyperkalemia, drug interactions, and deprescribing considerations.
Stopping Losartan: Check Which Treatment Goal Needs Replacing
Before stopping losartan, identify its treatment goal, record current blood pressure and lab results, and confirm the plan with your prescriber.
Switching Losartan: Check What the Original Prescription Treats
Before switching losartan, check whether it treats blood pressure, diabetic kidney disease, or another condition, and what the replacement needs to do.
What to Do When You Miss a Dose of Losartan
Losartan is an angiotensin II receptor blocker taken once daily, 25-100 mg. Miss a dose? Take it if 12+ hours remain before the next one; never double up.