Science · 2023
Named the Breakthrough of the Year
Science, one of the world's leading peer-reviewed journals, named GLP-1 medications for obesity its 2023 Breakthrough of the Year, citing evidence that the class blunts obesity-associated health problems beyond weight alone.
Science, Breakthrough of the Year 2023 ↗The research
Two large trials, published in NEJM
In the STEP 1 trial, adults on weekly semaglutide lost 14.9% of their body weight on average over 68 weeks. In SURMOUNT-1, adults on weekly tirzepatide lost between 16% and 22.5%. Both were published in the New England Journal of Medicine.
See the research breakdown→The cultural moment
One of the most-discussed health topics of the decade
From medical journals to national newspapers, GLP-1 medicine became one of the most widely covered health stories of the decade, shifting the conversation about weight from willpower toward biology and hormones.