The fragment HHS names
TB-500 is Ac-LKKTETQ, seven amino acids from the actin-binding region of thymosin beta-4. It is not the full 43-amino-acid protein.
- Injectable vialSupply
- TB-500 acetateStrength
- Provider reviewedBefore anything ships
The people pictured are models, not patients.
RxLongevity
TB-500
Real TB-500. A real US pharmacy.
40,000+ products sold · LegitScript certified
Done ordering "research use only" vials? In October 2026, HHS opened TB-500, a seven-amino-acid fragment of thymosin beta-4, to US 503A pharmacies. Now a licensed provider can prescribe it, and a state-licensed pharmacy makes it for you by name: one ingredient, cold-shipped to your door.
- From a US 503A pharmacy
- Single ingredient
- Provider reviewed
- Ships cold-packed
$99due today
then $139 per month for 5 months
Continue to checkoutShips in 5 to 7 days
Medication subject to provider approval. Full refund if not approved.
After checkout you complete a short medical review in your member portal, and a US-licensed provider reviews it before your TB-500 ships.
Full refund if not prescribed Free, discreet shipping
Order today and here is what happens next
- TodayChoose a plan, then a short online intake
- Within about 24 hoursA US-licensed provider reviews your request
- Ships in 5 to 7 daysEstimated ship date, if prescribed
- Full refund
- If a provider does not prescribe it
- Licensed clinicians
- An independent US-licensed clinician reviews every request
- US-licensed pharmacy
- Prepares and ships your prescription
- Discreet delivery
- Plain, unmarked packaging
Common questions
Is this the same TB-500 sold on research sites?
Same peptide, very different product. Research sites sell vials labeled not for human use, often made overseas, with no one checking whether it fits you. Ours is compounded by a state-licensed US 503A pharmacy from a prescription written for you, with your name and directions on the label.
Is TB-500 the same as thymosin beta-4?
No. TB-500 is a seven-amino-acid fragment of thymosin beta-4 (Ac-LKKTETQ). The full protein is 43 amino acids. HHS's policy names the fragment.
Is TB-500 legal to prescribe now?
Yes, under conditions. In October 2026, HHS said it will not take enforcement action against state-licensed 503A pharmacies that compound TB-500 from a patient-specific prescription and meet the policy's conditions, while FDA finishes its rule. HHS covers it as an injection under the skin or into muscle. It is still not FDA approved.
LegitScript certifiedCert. 50087439- US-licensed pharmacyPrepares every prescription
- Independent cliniciansUS-licensed, in your state
- 40,000+Products sold
- All 50 statesFree, discreet shipping
- No insurance requiredOne price, shown up front
Morning runs
Real TB-500. A real US pharmacy.
- 01From a US 503A pharmacy
- 02Single ingredient
- 03Provider reviewed
- 04Ships cold-packed
The people pictured are models, not patients.
Why TB-500
From a repair protein
Thymosin beta-4 binds actin and helps cells move during tissue repair, in lab and animal research.
One ingredient, pharmacy-made
TB-500 acetate on its own, compounded for you by a state-licensed US 503A pharmacy.
Price up front, refund if not prescribed
See every price before you pay. If your provider says no, you get a full refund.
How we compare
TB-500, without the waiting room.
HealthRX.comTypical in-person visit
Start online, no appointment or waiting roomBook, travel and wait
A US-licensed clinician reviews your history
Price shown before you startDepends on the visit and insurance
No insurance requiredOften billed through insurance
Delivered to your door in a plain boxPick up at the pharmacy
Full refund if you are not prescribedVisit fees usually apply either way
Understand your treatment
A fragment, not the whole protein.
TB-500 is often confused with thymosin beta-4. It is a seven-amino-acid piece of it, the region that binds actin. HHS's policy names this fragment, as an injection under the skin or into muscle.
A closer look
A fragment, not the whole protein.
Thymosin beta-4
LKKTETQ
Injection
Make a more informed choice
TB-500 vs. thymosin beta-4
Thymosin beta-4 is a 43-amino-acid protein studied in tissue repair. TB-500 is the acetylated LKKTETQ fragment. They are different molecules, and research on one does not automatically apply to the other.
Explore the ingredient research
- Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51.
- HHS. Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances, Appendices A and B. October 2026.
A straightforward path to care
Select your plan
Choose your treatment options and complete secure checkout. Then complete the online health intake.
Provider review
A US-licensed provider reviews your intake and prescribes TB-500 only if it is right for you.
Ships to your door
A state-licensed US 503A pharmacy makes it for you by name and ships it free in plain packaging, cold-packed.
Ongoing support
Message your care team with questions. Your provider can adjust or stop your plan.
- Provider review
- An independent US-licensed clinician reviews every request.
- Free, discreet shipping
- Filled by a US-licensed pharmacy and shipped in discreet packaging.
- Not prescribed?
- You get a full refund for the medication.
About TB-500
TB-500 is the acetylated seven-amino-acid fragment Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ). It copies the actin-binding region of thymosin beta-4, a 43-amino-acid protein studied in tissue repair. It is a different molecule from the full protein. Your vial holds TB-500 acetate as the only active ingredient, compounded by a US 503A pharmacy.
- A seven-amino-acid fragment of thymosin beta-4
- TB-500 acetate, the only active ingredient
- Injected under the skin or into muscle, as your provider directs
- Prescribed after a US-licensed provider review
Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (HHS Appendix B, 2026).
Thymosin beta-4
a 43-amino-acid protein found in most cells
Amino acids 17 to 23
its actin-binding region, LKKTETQ
TB-500
an acetylated copy of that seven-amino-acid region
A short fragment of a repair protein, made for you by a state-licensed US pharmacy.
What the research shows
TB-500 research leans on its parent protein, thymosin beta-4. Here is what the record shows.
7
amino acids make up TB-500: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln.
HHS Appendix B, 2026
Actin
is what thymosin beta-4 binds, helping cells move during tissue repair in lab and animal research.
Goldstein et al., Expert Opin Biol Ther 2012
2 routes
HHS's policy covers TB-500 under the skin or into muscle.
HHS 503A peptide policy, 2026
References
- Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51.
- HHS. Enforcement discretion policy regarding 503A compounding using certain peptide bulk drug substances, Appendices A and B. October 2026.
HealthRX.com or Research-use sites
Two very different ways to get TB-500
| HealthRX.com | Research-use sites | |
|---|---|---|
| Who makes it | A state-licensed US 503A pharmacy, from your prescription | Often overseas labs, sold as powder in a vial |
| Labeled for | You, by name, with your provider's directions | "Research use only. Not for human use." |
| Who checks it fits you | A US-licensed provider reviews your health history | No one |
| What is in it | TB-500 acetate, one ingredient | The seller's own claims |
| Questions later | Message your care team anytime | Seller support, if any |
| Price | Shown up front, full refund if not prescribed | Often less per vial, with no medical review |
What to expect
Here is how your first month goes, from checkout to your first refill.
Today
Choose a plan and do your intake
Checkout takes a few minutes, then a short online health intake.
Day 1 to 2
A provider reviews
A US-licensed provider reviews your intake and may message you with questions.
Within about a week
It arrives
If prescribed, the pharmacy ships it cold-packed in plain packaging, with your directions on the label.
Each month
Check in and refill
Message your care team anytime. Plans refill on schedule, and you can pause or cancel from your account.
Safety and side effects
TB-500 is compounded by a US-licensed 503A pharmacy and is not FDA approved. FDA has not reviewed it for safety, effectiveness or quality, and human studies are small. A licensed provider reviews your health history and medicines before deciding whether to prescribe it. It is not for use during pregnancy or breastfeeding, or by anyone under 18. Report side effects to your provider, or to FDA MedWatch at 1-800-FDA-1088.
Common
- Redness, swelling or itching where you inject
- A small bruise at the injection site
Less common
- Soreness at the injection site that lasts more than a day
Seek care
- Signs of an allergic reaction: hives, swelling of the face or throat, or trouble breathing
- Signs of infection where you inject: spreading redness, warmth or fever
Human safety data for TB-500 are limited. Tell your provider about every medicine you take before starting. This is not a complete list of side effects.
Frequently asked questions
What does the research show?
Thymosin beta-4, the protein TB-500 comes from, binds actin and helps cells move during tissue repair in lab and animal research (Goldstein et al., 2012). Research on the full protein does not automatically apply to the fragment. Your provider will go through what is and is not known.
How much does TB-500 cost?
Every plan price is on this page before you pay, and longer plans cost less per month. Each plan covers the online provider visit, the medication if prescribed and shipping. If the provider decides it is not right for you, you get a full refund.
Who should not take TB-500?
It is not for anyone pregnant, breastfeeding or under 18. Your provider reviews your health history and medicines before deciding.
How fast does it ship?
Usually 3 to 5 days after your provider approves it, cold-packed in a plain box. Shipping is free.
Can I pause or cancel?
Yes. Plans refill on their own schedule, and you can pause, change or cancel anytime from your account.
Other longevity options
Everyday essentials for your routine.
No prescription needed. Dietary supplements for the daily habits around your care, sold separately from prescription treatment. Ask your provider before adding one to your routine.
Dietary supplements, not medications. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Approval is never automatic.
An independent US-licensed clinician reviews every request. If they decide the treatment is not right for you, you get a full refund for the medication.
Choose a planNo insurance required
Prescriptions are filled by a US-licensed pharmacy and shipped free, in discreet packaging, on every plan.
LegitScript-certified · Cert 50087439
Compounded medications are prepared by a US-licensed pharmacy and are not reviewed by the FDA for safety or effectiveness. Products are dispensed only after a licensed provider determines they are appropriate. Information here is educational and is not a substitute for medical advice.