PEARL Extension Data and What Happened After the Trial Ended
Deep dive into the PEARL trial's follow-up and extension findings for weekly rapamycin in healthy adults, covering durability of effects, safety signals, and long-term outcome data.
Trials Awmf Rapa Pearl
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May 25, 2026latest review
Trials Awmf Rapa Pearl library
Showing 3 of 3 clinical reviews.
PEARL Medicine Trial: What It Changes in Practice
PEARL tested weekly rapamycin in older adults over 48 weeks, showing modest quality-of-life gains and no major safety issues, but no updated guidelines yet.
PEARL Results in Detail: Numbers, Subgroups, and Time Course
A detailed breakdown of the PEARL trial's rapamycin results in healthy older adults, including effect sizes, secondary endpoints, immune markers, and time-course patterns from this landmark 2024 Aging Cell RCT.
