Review
Azelaic Acid
. PMID 30000482.
This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.
Read the PubMed recordSkin
Azelaic acid: the research history.
Azelaic acid appears in a skincare blend with tretinoin and niacinamide. Its topical research includes multiple skin conditions and concentrations.
1,042records matching the ingredient search
1connected formulations
8displayed publication records
How the research connects to the formula
The catalog lists azelaic acid 5%, tretinoin 0.03% and niacinamide 4%. A source using another azelaic-acid strength or a single-ingredient vehicle can be placed beside this formulation without treating the two as identical.
A comparison should retain the study diagnosis and endpoint. Acne lesion counts, rosacea measures and pigmentation measures describe different research questions.
| Product | Listed formulation | Connected ingredient research |
|---|---|---|
| Azelaic Acid Cream | Azelaic Acid 5% / Tretinoin 0.03% / Niacinamide 4% | Azelaic acid · Tretinoin · Niacinamide |
Publication history
When the ingredient appeared in the literature
The chart counts records mentioning the search terms in their title or abstract. It includes research beyond skin. Use the period controls to inspect the count.
2026: 60 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.
View the chart as a data table
| Period | Publications |
|---|---|
| 1900-1959 | 0 |
| 1960-1969 | 6 |
| 1970-1979 | 6 |
| 1980-1989 | 61 |
| 1990-1999 | 78 |
| 2000-2009 | 168 |
| 2010-2014 | 146 |
| 2015-2019 | 173 |
| 2020 | 45 |
| 2021 | 47 |
| 2022 | 56 |
| 2023 | 42 |
| 2024 | 78 |
| 2025 | 76 |
| 2026 | 60 |
Search query and data source
Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.
TITLE_ABS:("azelaic acid") AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]
A closer search for this product question
The focused search returns 357 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.
View the focused query
TITLE_ABS:("azelaic acid") AND TITLE_ABS:((acne OR rosacea)) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]
Dated publications
Read individual records in context
The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.
Questions that shape the comparison
Which diagnosis, concentration and vehicle did the source use? Were the other catalog ingredients included?
Source records
Azelaic Acid. 2026-03-15. PMID 30000482. Review.
Azelaic acid-integrated therapeutic deep eutectic systems: overcoming solubility and permeability barriers for enhanced transdermal drug delivery.Du L, Wang S, Chen H, Liu C, Yang S, Wang Y, Cai B, Yang J, Ding Y.RSC advances. 2026-04-13. PMID 41983181. research-article, Journal Article.
Pustular Rosacea in an 8-Year-Old Patient: A Rare Presentation of Pediatric Rosacea.Sharaf R, Assaf T, Ghanem UI, Alhameed HA, Adwan R.Case reports in dermatological medicine. 2026-04-27. PMID 42051591. case-study, Journal Article.
1,2-Reduction of β,γ-Unsaturated α-Keto Esters by Indium(I) Chloride-Water/Azelaic Acid.Qiu H, Hu L, Ju K, Lyu M, Song R, Yang D, Hu Z, Lv J.The Journal of organic chemistry. 2026-07-01. PMID 42457637. Journal Article.
Clinical outcomes associated with a digital standardized skin care regimen in acne-rosacea comorbidity: A real-world longitudinal study with cross-lagged and mediation analyses.Qing Y, Zhang K, Xu B, Wang Y, Xiao T, Yang P, Yang Y, Yu B, Sun H, Wu N, Zhang T, Wu J.Journal of the American Academy of Dermatology. 2026-07-14. PMID 42455099. Journal Article.
Azelaic Acid delays aging and prolongs lifespan via resisting oxidation stress mediated by IIS pathway coupling hsf-1 in C. elegans.Chen Y, Wang L, Zhu Z, Pan B, Bai J.Bioscience, biotechnology, and biochemistry. 2026-08-19. PMID 42616001. Journal Article.
Milling-Induced Chitosan-HPMC Microstructural Organisation Determines the Stability Window of Concentrated Azelaic Acid Nanosuspensions.Miočić S, Rašić A, Torić J, Abrami M, Ferderber K, Cetina-Čižmek B, Grassi M, Filipović-Grčić J.Pharmaceutics. 2026-08-27. PMID 42797246. research-article, Journal Article.
Azelaic acid from Pseudomonas nicosulfuronedens MiC45 as an effective compound against Meloidogyne incognita in susceptible pepper.Xiao J, Deng X, Zhao W, Zhang L, Xie K, Chen L, Wan J, Liao H.Pest management science. 2026-09-08. PMID 42706921. Journal Article.
Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.