Longevity

Vitamin B12 / cyanocobalamin: the research history.

The vitamin B12 product identifies cyanocobalamin. The atlas includes the broader vitamin B12 term, so each publication’s specific form needs to stay visible.

21,991records matching the ingredient search
1connected formulations
8displayed publication records

How the research connects to the formula

Research about deficiency replacement asks a different question from research in participants with adequate baseline B12. Baseline status, laboratory criteria and the administered preparation identify that difference.

A comparison with the catalog should also retain the route and dose recorded by the source. Another vitamin B12 form or a different route is connected research, not an identical intervention.

Current HealthRX.com formulation map
ProductListed formulationConnected ingredient research
Vitamin B12 Injection (Cyanocobalamin)Vitamin B12 (Cyanocobalamin)Vitamin B12 / cyanocobalamin

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond longevity. Use the period controls to inspect the count.

2026: 801 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table
PeriodPublications
1900-19592357
1960-19691437
1970-19791397
1980-19891550
1990-19991936
2000-20093262
2010-20142236
2015-20192522
2020609
2021645
2022681
2023743
2024849
2025966
2026801
Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:((cyanocobalamin OR "vitamin B12")) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 154 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:((cyanocobalamin OR "vitamin B12")) AND TITLE_ABS:((deficiency AND randomized)) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Journal Article

Hippophae rhamnoides: Way to Ameliorate Depressive Augury by Cyanocobalamin.

Garg K, Bajaj S, Rajput R, Singla R. Current drug discovery technologies. PMID 41487001.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Did participants have documented deficiency? Which B12 form, route and endpoint were used?

Source records

Hippophae rhamnoides: Way to Ameliorate Depressive Augury by Cyanocobalamin.Garg K, Bajaj S, Rajput R, Singla R.Current drug discovery technologies. 2026-01-02. PMID 41487001. Journal Article.
Rapid Restoration of Circulating Vitamin B12 Levels by Using Oral Sucrosomial<sup>®</sup> Vitamin B12 in Metformin-Associated B12 Deficiency: Results from a Double-Blind, Placebo-Controlled Randomized Clinical Trial.Conti G, Kalo AW, Ujjan I, Aslam A, Khan A, Memon NM, Kakar SZ, Ahmed N, Zahid S, Tarantino G, Brilli E.Pharmaceutics. 2026-02-13. PMID 41754978. research-article, Journal Article.
Sublingual methylcobalamin treatment in infants with prolonged jaundice due to vitamin B12 deficiency.Aydin S, Oz A, Turkmen H, Altin H.Frontiers in pediatrics. 2026-04-29. PMID 42137564. research-article, Journal Article.
Vitamin B12 desensitization and provocation: Ten-year clinical experience.Dindar Çelik F, Aksu K, Göktürk Ö, Karahan Y, Baştuğ İnan NB, Uslu B, Demir Ş, Çelik E.The World Allergy Organization journal. 2026-05-29. PMID 42256019. research-article, Journal Article.
Prevalence of vitamin B12 deficiency and associated factors in pregnant Spanish women.Cruz-Rodríguez J, Canals-Sans J, Jardí C, Arija V.Women & health. 2026-07-01. PMID 42643091. Journal Article.
Comparative Efficacy of Intranasal, Intramuscular, and Intravenous Vitamin B12 Therapy for Hematological Recovery in Vitamin B12 Deficiency Anemia: A Randomized Controlled Trial.Singh SK, Arora R, Pramanik SK, Kumar A, Singh A, Khanna S, Malhotra N, Juneja P, Upadhyay N, Yanamandra U.American journal of hematology. 2026-07-02. PMID 42393020. Comparative Study, research-article, Randomized Controlled Trial, Journal Article.
Vitamin B12 Deficiency Presenting as Anemia and Functional Decline in an Older Adult: A Case Report.Sosa Sarmiento PV, Hernandez DA, Ocampo-Chaparro JM, Reyes-Ortiz CA, Matos Furones Y.Cureus. 2026-07-12. PMID 42582968. Journal Article, Case Reports, case-report.
Oral Cyanocobalamin Treatment in Infants Under 1 Year With Nutritional Vitamin B12 Deficiency: A Retrospective Comparison of 500 and 1000 µg Dose Regimens.Reis İskenderoğlu GP, Erduran E, Eroğlu N, Bahadır A.Journal of pediatric hematology/oncology. 2026-09-03. PMID 42691328. Comparative Study, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.