Glutathione: Research History & Formulation Comparisons

How the research connects to the formula

The ingredient-name search reaches research on glutathione within normal biology, laboratory experiments and administered preparations. Those categories should not be treated as a single set of treatment trials.

For this catalog connection, injectable-route research is more specific than an ingredient mention. Oral preparations, topical preparations and studies measuring endogenous glutathione remain separate branches of the evidence map.

Current HealthRX.com formulation map
Product	Listed formulation	Connected ingredient research
Glutathione Injection	Glutathione 200 mg/mL	Glutathione

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond longevity. Use the period controls to inspect the count.

2026: 7,437 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table

Period	Publications
1900-1959	554
1960-1969	822
1970-1979	2257
1980-1989	9417
1990-1999	22268
2000-2009	35574
2010-2014	24326
2015-2019	27829
2020	6997
2021	7198
2022	7698
2023	7356
2024	8040
2025	9216
2026	7437

Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(glutathione) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 1,386 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:(glutathione) AND TITLE_ABS:((intravenous OR injectable)) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Journal Article

Engineered senescence-targeting apoptotic extracellular vesicles-laden injectable hydrogel microspheres mitigating nucleus pulposus cell ferroptosis against intervertebral disc degeneration.

Shi P, Yang ZR, Wu W, Cheng Z, Gao H, Chen Y, Chen X, Yang C, Zhu J, Jiang H, Zhang Y. Biomaterials. PMID 42475907.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Was glutathione administered, or only measured as a biological marker? If administered, what route, quantity and outcome did the source use?

Source records

Engineered senescence-targeting apoptotic extracellular vesicles-laden injectable hydrogel microspheres mitigating nucleus pulposus cell ferroptosis against intervertebral disc degeneration.Shi P, Yang ZR, Wu W, Cheng Z, Gao H, Chen Y, Chen X, Yang C, Zhu J, Jiang H, Zhang Y.Biomaterials. 2026-07-14. PMID 42475907. Journal Article.

Glutathione Biology in Neurodegenerative and Metabolic Diseases: Molecular Mechanisms, Pathophysiological Roles, and Therapeutic Perspectives.Gromadzka G, Kąkol M, Klimkiewicz M, Bendykowska M.International journal of molecular sciences. 2026-08-21. PMID 42653505. review-article, Review, Journal Article.

Injectable hyaluronic acid/polyvinyl alcohol/ferrocene-based hydrogel local delivery platform toward synergistic chemotherapy/ferroptosis therapy of breast cancer.Guo Y, Xiao Z, Wang F, Zhu G, Sun J, Liu Y.International journal of biological macromolecules. 2026-09-08. PMID 42710767. Journal Article.

Intracellularly actuated biomimetic nanorobots for chemo-mechanical breast cancer therapy.Bai S, Wang R, Chen T, Ma X, Gao C, Wu A.Biomaterials. 2026-09-09. PMID 42727297. Journal Article.

Postharvest senescence of green vegetables and the role of glutathione metabolism: current state of knowledge and future research opportunities.Bozzo GG, Sivakumar D, Yan Y, Beltrán Plascencia A.Frontiers in plant science. 2026-09-09. PMID 42781382. review-article, Review, Journal Article.

Glutathione-Related Responses to Hyperglycemic and Hyperosmotic Stress in Cultured Human Retinal Pericytes and Endothelial Cells: An Exploratory Study.Pavlovschi E, Darii F, Pantea V, Curtev Ș, Trocin C, Curlat S, Ușurelu DC, Mărițoi T, Tagadiuc O.Biomedicines. 2026-09-18. PMID 42792844. research-article, Journal Article.

Glutaredoxins Rapidly Reduce Glutathione Hydroper- and Polysulfides.Reinert P, Ogata S, Leiskau L, Yildiz SS, Akaike T, Barayeu U, Deponte M.Angewandte Chemie (International ed. in English). 2026-09-21. PMID 42766334. Journal Article.

Expression of Concern for Chronic stress-induced ANPEP drives liver cancer progression by increasing glutathione synthesis and inhibiting ferroptosis.Wu Y, Zhang Y, Shi X, Wu M, Sun M, Feng Y, Ma W, Jiang X, Fei D, Zhao M, Wu Z, Li C, Liang X, Gao L, Ma C, Yue X.The Journal of clinical investigation. 2026-10-01. PMID 42820296. expression-of-concern, Expression of Concern.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.