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Skin

Ivermectin: the research history.

Ivermectin appears in HealthRX.com’s rosacea cream. The atlas keeps its topical skin research distinct from the wider literature returned by an ingredient-name search.

8,845records matching the ingredient search
1connected formulations
8displayed publication records

How the research connects to the formula

The catalog combines ivermectin 0.88% with oxymetazoline 0.88% and niacinamide 4%. The exact blend differs from a single-ingredient topical preparation and from ivermectin administered by another route.

That distinction is useful when comparing studies across the formula. Each paper’s condition, route, concentration and measured outcome identify the part of the product question it can address.

Current HealthRX.com formulation map
ProductListed formulationConnected ingredient research
Rosacea Cream (Oxymetazoline + Ivermectin)Oxymetazoline 0.88% / Ivermectin 0.88% / Niacinamide 4%Oxymetazoline · Ivermectin · Niacinamide

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond skin. Use the period controls to inspect the count.

2026: 416 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table
PeriodPublications
1900-19590
1960-19690
1970-19790
1980-1989505
1990-19991290
2000-20091524
2010-20141018
2015-20191327
2020420
2021502
2022535
2023441
2024429
2025438
2026416
Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(ivermectin) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 149 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:(ivermectin) AND TITLE_ABS:(rosacea) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Randomized Controlled Trial · Journal Article

Treatment of redness in rosacea with potassium-titanyl-phosphate (KTP) 532 nm laser with and without topical 1% ivermectin cream: a randomized split-face trial.

Heidemeyer K, Cazzaniga S, Junge A, Lehmann M, Seyed Jafari SM, Yawalkar N, Feldmeyer L, Bossart S. The Journal of dermatological treatment. PMID 41778357.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Was ivermectin applied to skin or administered another way? Did the study examine rosacea and the full combination?

Source records

Treatment of redness in rosacea with potassium-titanyl-phosphate (KTP) 532 nm laser with and without topical 1% ivermectin cream: a randomized split-face trial.Heidemeyer K, Cazzaniga S, Junge A, Lehmann M, Seyed Jafari SM, Yawalkar N, Feldmeyer L, Bossart S.The Journal of dermatological treatment. 2026-03-04. PMID 41778357. Randomized Controlled Trial, Journal Article.
Understanding Patient Perspectives on Rosacea: A Cross-Sectional Analysis of the r/Rosacea Forum on Reddit.Goyal SP, Friedman A.Journal of drugs in dermatology : JDD. 2026-06-01. PMID 42235047. Journal Article.
ALSUntangled #84 - ivermectin.Helmold B, Armon C, Benatar M, Bertorini T, Bromberg M, Brown A, Cadavid JM, Carbunar O, Carter GT, Crayle J, Feldman E, Foucher J, Glass J, Greenstein E, Jhooty S, Jiang N, Kochen NN, McDermott C, Olby N, Pattee G, Porter D, Premasari A, Rao A, Ratner D, Staats K, Tito E, Vieira F, Wicks P, Bedlack R.Amyotrophic lateral sclerosis & frontotemporal degeneration. 2026-08-06. PMID 42561977. Journal Article.
Topical treatment of rosacea: update and outlook.Ji C, Lane ME.International journal of pharmaceutics. 2026-08-27. PMID 42660372. Review, Journal Article.
Ivermectin impacts the life history strategy of Chaetopteryx villosa.Stern JS, Meyer F, Bollinger E, Ringbeck B, Pridöhl J, Feckler A, Bundschuh M.Aquatic toxicology (Amsterdam, Netherlands). 2026-08-30. PMID 42715876. Journal Article.
Ivermectin Inhibits Stress Granule Clearance by Blocking the De Novo Synthesis of Hsp70 in Neuroblastoma Cells.Chu S, Anim EP, Salehi-Tabar R, White JH, Stochaj U.Cells. 2026-09-07. PMID 42738916. research-article, Journal Article.
The Degradation of Ivermectin in the Barn Ground Following Subcutaneous Administration in Beef Cattle.Akyol BA, Sen H, Gokbulut C.Bulletin of environmental contamination and toxicology. 2026-09-23. PMID 42776223. Journal Article.
ABCB1 Frameshift Deletion in Skye Terriers With Potential Pharmacogenetic Relevance.Nielsen M, Gredal H, Karlsson Å, Meadows JRS, Arendt M.Animal genetics. 2026-10-01. PMID 42770779. brief-report, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.