Longevity

NAD+: the research history.

NAD+ connects an injectable product with a nasal product. The literature search includes nicotinamide adenine dinucleotide and NAD+, while keeping precursor research separate from the catalog’s stated ingredient.

61,390records matching the ingredient search
2connected formulations
8displayed publication records

How the research connects to the formula

The injection listing uses a monthly quantity; the nasal listing gives a concentration and bottle volume. These fields describe different aspects of a formulation and cannot be compared as if they were the same administered dose.

A paper studying a precursor such as nicotinamide riboside answers a different intervention question from a paper administering NAD+ itself. The atlas preserves the exact paper title and source to make that distinction inspectable.

Current HealthRX.com formulation map
ProductListed formulationConnected ingredient research
NAD+ Injection1,000 mg per monthNAD+
NAD+ Nasal Spray300 mg/ml, 15 ml bottleNAD+

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond longevity. Use the period controls to inspect the count.

2026: 2,061 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table
PeriodPublications
1900-19591154
1960-19692432
1970-19795358
1980-19896152
1990-19997015
2000-200910084
2010-20146993
2015-20198014
20201902
20212006
20222029
20231936
20242026
20252228
20262061
Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(("nicotinamide adenine dinucleotide" OR "NAD+")) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 295 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:(("nicotinamide adenine dinucleotide" OR "NAD+")) AND TITLE_ABS:((intravenous OR intranasal)) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

research-article · Journal Article

Placental nicotinamide adenine dinucleotide modulates the timing of labor.

Ciampa EJ, Machado LM, Lee KJ, Clark AJ, Vu KQ, Khan NA, Kispert S, Armstrong S, Li Y, Milne GL, Solmonson A, Karumanchi SA, Parikh SM. Science (New York, N.Y.). PMID 42275500.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Was the intervention NAD+ itself, a precursor or a laboratory manipulation? Did the source test the injectable or nasal route?

Source records

Placental nicotinamide adenine dinucleotide modulates the timing of labor.Ciampa EJ, Machado LM, Lee KJ, Clark AJ, Vu KQ, Khan NA, Kispert S, Armstrong S, Li Y, Milne GL, Solmonson A, Karumanchi SA, Parikh SM.Science (New York, N.Y.). 2026-06-11. PMID 42275500. research-article, Journal Article.
Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction.Yoo SH, Jang JY, Bae JS, Ventura R, Kim EH, Kim AY, Mo JH, Park J, Kang K, Yun Y, Lee JH, Kim YJ, Lee DJ, Kim JH.Experimental & molecular medicine. 2026-07-01. PMID 42380286. research-article, Journal Article.
The role of redox state in regulating plant secondary metabolism under stress.Wan S, Yao L, Su H.Functional plant biology : FPB. 2026-07-01. PMID 42482299. Review, Journal Article.
Tracing NAD<sup>+</sup> metabolism uncovers adaptive coordination between host and microbiome during colitis.Alsaadi AI, Wehkamp L, Pothakamury AA, Yahia MS, Prasad P, Gilloteau C, Sadler J, Smith JD, Jenkins BC, Diven GS, Bornhäuser J, Mekdoud T, Tian S, Rosenstiel P, Schreiber S, Bisanz JE, Aden K, McReynolds MR.Cell reports. 2026-07-25. PMID 42501334. research-article, Journal Article.
[NAD kinases (NADKs) family proteins: Advances in metabolic regulation mechanisms and disease associations].Cheng SY, Pan HY, Wang D, Jin X, Cheng QM, Gao CJ, Shi LH.Sheng li xue bao : [Acta physiologica Sinica]. 2026-08-01. PMID 42677414. Review, Journal Article, English Abstract.
A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes.Saleh S, Hsu NH, Luu E, Martin VC, Ng HJC, Black WB, Zhang S, Kim JK, Sankaran B, Tran AHT, Hayes RL, Siegel JB, Qiao F, Li H.Nature chemical biology. 2026-09-09. PMID 42717052. Journal Article.
Non-clinical safety evaluation of coenzyme I (NAD⁺): A GLP-compliant systematic study.Gu J, Xu J, Yang S, Qiu Y, Yin L, Xu N.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2026-09-16. PMID 42748828. Journal Article.
Metabolism of Nicotinamide Adenine Dinucleotide+ in Atherosclerosis: Mechanisms and Nutritional Modulation.Zhu J, Li J, Qin Y, Cui Y, Mou L.Nutrition reviews. 2026-09-23. PMID 42776599. Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.